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The Human Papillomavirus Type 16 E5 Protein Modulates ERK1/2 and p38 MAP Kinase Activation by an EGFR-Independent Process in Stressed Human Keratinocytes

Crusius, Kerstin, Rodriguez, Isabel, Alonso, Angel·2000·Virus Genes
DOI 10.1023/a:1008112207824
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Abstract

The human papillomavirus type 16 E5 gene product has been shown to upregulate the activation of MAP kinases ERK1/2 and cellular proliferation promoted by EGF in a ligand-dependent process. We now report the growth factor-independent modulation of MAP kinases by HPV 16 E5 in human keratinocytes. After treatment with 600 mM sorbitol or low concentrations of anisomycin, E5-expressing cells upregulate the activation of ERK1/2. In addition, E5 enhances p38 activation after anisomycin but not after sorbitol treatment, but it has no effect on MAP kinases activation after shocking the cells with 300 mM sodium chloride. The E5-mediated, sorbitol-dependent increase in ERK1/2 activation is EGF-independent and is only partially inhibited by tyrphostin AG1478, which is known to inhibit specifically EGF receptor activation.

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Research works printed but not linked: 24

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Metadata

Authors
Crusius, K., Rodriguez, I., & Alonso, A.
Venue
Virus Genes
Publisher
Springer Science and Business Media LLC
Published
2000-02
Volume
20
Issue
1
Pages
65-69
ISSN
  • 0920-8569
  • 1572-994X
DOI
10.1023/a:1008112207824
Cited by
54
References
0
Language
en
Licence

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CoChat. (2026). Citation check: The Human Papillomavirus Type 16 E5 Protein Modulates ERK1/2 and p38 MAP Kinase Activation by an EGFR-Independent Process in Stressed Human Keratinocytes. https://app.cochat.ai/papers/10.1023/a:1008112207824
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Crusius, K., Rodriguez, I., & Alonso, A. (2000). The Human Papillomavirus Type 16 E5 Protein Modulates ERK1/2 and p38 MAP Kinase Activation by an EGFR-Independent Process in Stressed Human Keratinocytes. Virus Genes. https://doi.org/10.1023/a%3A1008112207824