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Cited by 211Gastrointestinal motility and disordersGastrointestinal Bleeding Diagnosis and TreatmentEnhanced Recovery After Surgery

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

How Useful Is Paracetamol Absorption as a Marker of Gastric Emptying? A Systematic Literature Study

Willems, Marleen, Quartero, A. Otto, Numans, Mattijs E.·2001·Digestive Diseases and Sciences
DOI 10.1023/a:1011935603893
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Abstract

Functional dyspepsia is a common disorder in primary care and gastroenterology units; however, the pathophysiology is poorly understood. Delayed gastric emptying is present in nearly 40% of patients. We evaluated the validity of the paracetamol absorption test in comparison with scintigraphy for gastric emptying assessment. Studies comparing scintigraphy with paracetamol absorption were selected through a structured Medline search. A correlation coefficient between scintigraphy and paracetamol absorption over 0.6 was considered good, between 0.45 and 0.6 intermediate, and below 0.45 poor. Feasibility was assessed by studying the administration of paracetamol, frequency of blood sampling, duration of the test period, and parameters used in the analysis. Thirteen studies were identified, eight (127 subjects) found a good correlation between scintigraphy and paracetamol absorption, two studies (28 subjects) found a moderate correlation, and three (25 subjects) found no correlation. Parameters used were area under the curve (N = 9), fixed-time concentrations (N = 6), concentration-max (N = 4) and time-to-concentration-max (N = 5). Repetitive blood samples ranged from 6 to 20 samples. The durations were 1.5-8 h. In conclusion, the paracetamol absorption technique generally correlates well to scintigraphy of liquid phase gastric emptying. The execution and outcome parameters however need further standardization to optimize its' value for clinical use and research purposes.

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  1. Heading RC, Bolondi L, Camilleri M, Corinaldesi R, Horowitz M, Jian R, Scarpignato R: Gastric emptying. Gastroenterol Int 5(4):203–215, 1992

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Metadata

Authors
Willems, M., Quartero, A. O., & Numans, M. E.
Affiliations
University Medical Center Utrecht (NL)
ORCID
Numans, Mattijs E.
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
2001-10
Volume
46
Issue
10
Pages
2256-2262
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
DOI
10.1023/a:1011935603893
OpenAlex
W1510097375
Cited by
211
References
41
Citations by year
2026: 7 · 2025: 10 · 2024: 12 · 2023: 14 · 2022: 12 · 2021: 11 · 2020: 14 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 16 · 2012: 9
FWCI
2.83
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
Keywords
gastric emptying, scintigraphy, functional dyspepsia, delayed gastric emptying, test validity, test standardization, test length
MeSH terms
Acetaminophen, Dyspepsia, Gastric Emptying, Humans, Intestinal Absorption, Reproducibility of Results, Analgesics, Non-Narcotic

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