Inhibition of gastric emptying and drug absorption by narcotic analgesics
Open accessAbstract
The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorphine will retard the absorption of other orally administered drugs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Delayed gastric emptying may create a motionless environment favorable to bacterial growth.
“Delayed gastric emptying (176) may create a motionless environment favorable to bacterial growth (177).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [176]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The dependence of paracetamol absorption on the rate of gastric emptying
Heading, R. C., Nimmo, J., Prescott, L. F., & Tothill, P. (1973) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1973.tb08339.x · Cited by 569 · see citing works
Self-citationNARCOTIC ANALGESICS AND DELAYED GASTRIC EMPTYING DURING LABOUR
Nimmo, W. S., Wilson, J., & Prescott, L. F. (1975) · The Lancet · doi:10.1016/s0140-6736(75)91687-6 · Cited by 287 · see citing works
Self-citationNimmo, J., Heading, R. C., Tothill, P., & Prescott, L. F. (1973) · BMJ · doi:10.1136/bmj.1.5853.587 · Cited by 228 · see citing works
Self-citationGASTRIC EMPTYING TIME IN LATE PREGNANCY AND LABOUR
Davison, J. S., Davison, M. C., & Hay, D. M. (1970) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1970.tb03405.x · Cited by 177 · see citing works
Effects of Morphine and Other Drugs on Motility of the Terminal Ileum
Daniel, E. E., Sutherland, W., & Bogoch, A. (1959) · Gastroenterology · doi:10.1016/s0016-5085(59)80075-5 · Cited by 143 · see citing works
Absorption of Effervescent Aspirin during Migraine
Volans, G. N. (1974) · BMJ · doi:10.1136/bmj.4.5939.265 · Cited by 113 · see citing works
Gas-liquid chromatographic estimation of paracetamol
Prescott, L. F. (1971) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1971.tb08613.x · Cited by 80 · see citing works
Self-citationEFFECT OF MORPHINE ON SOME SYMPATHETICALLY INNERVATED EFFECTORS
Cairnie, A. B., Kosterlitz, H. W., & TAYLOR, D. W. (1961) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1961.tb01141.x · Cited by 79 · see citing works
An evaluation of 113mindium DTPA chelate in the measurement of gastric emptying by scintiscanning
Heading, R. C., Tothill, P., Laidlaw, A. J., et al. (1971) · Gut · doi:10.1136/gut.12.8.611 · Cited by 77 · see citing works
Self-citationEffect of Metoclopramide on Gastric Emptying during Labour
Howard, F. A., & Sharp, D. S. (1973) · BMJ · doi:10.1136/bmj.1.5851.446 · Cited by 77 · see citing works
Pattern of Gastric Emptying after Vagotomy and Pyloroplasty
Colmer, M. R., Owen, G. M., & Shields, R. C. (1973) · BMJ · doi:10.1136/bmj.2.5864.448 · Cited by 74 · see citing works
AN ASSESSMENT OF GASTRIC EMPTYING BY BREATHALYSER
FINCH, J. E., Kendall, M. J., & MITCHARD, M. (1974) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1974.tb00242.x · Cited by 30 · see citing works
RESPONSES OF ISOLATED DOG SMALL INTESTINE TO ANALGESIC AGENTS
Burks, T. F., & Long, J. P. (1967) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27791-6 · Cited by 30 · see citing works
Renal Insensitivity to Frusemide Caused by Chronic Anticonvulsant Therapy
Ahmad, S. (1974) · BMJ · doi:10.1136/bmj.3.5932.657 · Cited by 23 · see citing works
The Effect of Morphine Sulfate on Gastric Motility. Some Radiologic Observations in Man
Crone, R. S., & Ardran, G. M. (1957) · Gastroenterology · doi:10.1016/s0016-5085(57)80090-0 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
How Useful Is Paracetamol Absorption as a Marker of Gastric Emptying? A Systematic Literature Study
Willems, M., Quartero, A. O., & Numans, M. E. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1011935603893 · Cited by 211 · see citing works
Acetaminophen: Old Drug, New Issues
Aminoshariae, A., & Khan, A. (2015) · Journal of Endodontics · doi:10.1016/j.joen.2015.01.024 · Cited by 146 · see citing works
Buckley, N. A., Buckley, N., Whyte, I. M., O'Connell, D. L., & Dawson, A. H. (1999) · Journal of Toxicology: Clinical Toxicology · doi:10.1081/clt-100102452 · Cited by 112 · see citing works
Neale, J., Nettleton, S., Pickering, L., & Fischer, J. (2012) · Addiction · doi:10.1111/j.1360-0443.2011.03660.x · Cited by 110 · see citing works
Pharmacokinetic Drug Interactions with Gastrointestinal Motility Modifying Agents
Greiff, J. M. C., & Rowbotham, D. (1994) · Clinical Pharmacokinetics · doi:10.2165/00003088-199427060-00004 · Cited by 72 · see citing works
Pharmacokinetic Considerations in Gastrointestinal Motor Disorders
Hebbard, G. S., Sun, W. M., Bochner, F., & Horowitz, M. (1995) · Clinical Pharmacokinetics · doi:10.2165/00003088-199528010-00005 · Cited by 51 · see citing works
A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health
Wiss, D. A. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00193 · Cited by 41 · see citing works
The Role of Nutrition in Addiction Recovery
Wiss, D. A. (2019) · The Assessment and Treatment of Addiction · doi:10.1016/b978-0-323-54856-4.00002-x · Cited by 20 · see citing works
Kim, G. W., Roh, Y.-I., Cha, K.-C., Hwang, S. O., Han, J. H., & Jung, W. J. (2022) · Acute and Critical Care · doi:10.4266/acc.2022.00696 · Cited by 4 · see citing works
- Authors
- Nimmo, W., Heading, R., Wilson, J., Tothill, P., & Prescott, L.
- Affiliations
- Edinburgh Royal Infirmary (GB)
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1975-12
- Volume
- 2
- Issue
- 6
- Pages
- 509-513
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- PMC
- PMC1402648
- OpenAlex
- W2008938165
- Cited by
- 269
- References
- 15
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 11 · 2019: 4 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 12 · 2014: 5 · 2013: 6 · 2012: 1
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Clinical Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- gastric emptying, drug absorption, opioid analgesics, pethidine, heroin, paracetamol, oral administration, drug-drug interactions, intramuscular administration
- MeSH terms
- Acetaminophen, Adult, Analgesics, Opioid, Depression, Chemical, Heroin, Pharmaceutical Preparations, Gastrointestinal Motility, Humans, Intestinal Absorption, Male, Meperidine, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
