The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Tissue inhibitors of metalloproteinases and programmed cell death: Conundrums, controversies and potential implications
Abstract
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, which can synergistically degrade the major components of extracellular matrix (ECM). A key role in maintaining the balance between ECM deposition and degradation in several physio-pathological processes is carried out, through multiple biological functions, by four members of the tissue inhibitors of metalloproteinases (TIMPs) family. TIMP-1 and TIMP-2 are capable of inhibiting the activities of MMPs, can inhibit tumour growth, invasion and metastasis, exhibit growth factor-like activity, can inhibit angiogenesis and suppress programmed cell death (PCD) independently of the MMP-inhibitory activity. TIMP-3 is the only member which is tightly bound to ECM, inhibits TNF-alpha converting enzyme and induces PCD through the stabilization of TNF-alpha receptors on the cell surface. TIMP-4 plays a role in ECM homeostasis in a tissue-specific fashion and its overexpression induces PCD. The aim of this article is to review the exciting and intriguing literature on TIMPs, with special emphasis on their conflicting-paradoxical roles in PCD and their potential clinical usefulness.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Importantly, it inhibits tumor necrosis factor alpha-converting enzyme and induces apoptosis through the stabilization of tumor necrosis factor alpha receptors on the cell surface (42).”
From MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008) · cites this paper as [42]
Citations
Cites
Nagase, H., & Woessner, J. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21491 · Cited by 3,912
Tissue inhibitors of metalloproteinases: evolution, structure and function
Brew, K., Dinakarpandian, D., & Nagase, H. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(99)00279-4 · Cited by 1,908
Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.
Gomez, D. E., Alonso, D. F., Yoshiji, H., & Thorgeirsson, U. P. (1997) · PubMed · Cited by 1,508
Cryns, V., & Yuan, J. (1998) · Genes & Development · doi:10.1101/gad.12.11.1551 · Cited by 1,228
Cancer risk in patients with inflammatory bowel disease: A population-based study
Bernstein, C. N., Blanchard, J., Kliewer, E. V., & Wajda, A. (2001) · Cancer · doi:10.1002/1097-0142(20010215)91:4<785::aid-cncr1065>3.0.co;2-r · Cited by 1,179
Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix
Boudreau, N., Sympson, C. J., Werb, Z., & Bissell, M. J. (1995) · Science · doi:10.1126/science.7531366 · Cited by 1,175
Proteolytic remodeling of extracellular matrix
Birkedal-Hansen, H. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80116-2 · Cited by 1,074
TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3
Amour, A., Slocombe, P. M., Webster, A., Butler, M., Knight, C. G., Smith, B. J., Stephens, P. E., Shelley, C., Hutton, M., Knäuper, V., et al. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01031-x · Cited by 609
Baker, A. H., Zaltsman, A. B., George, S. J., & Newby, A. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1584 · Cited by 464
Guedez, L., Stetler-Stevenson, W. G., Wolff, L., Wang, J., Fukushima, P., Mansoor, A., & Stetler-Stevenson, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2881 · Cited by 397
Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate
Garbisa, S., Sartor, L., Biggin, S., Salvato, B., Benelli, R., & Albini, A. (2001) · Cancer · doi:10.1002/1097-0142(20010215)91:4<822::aid-cncr1070>3.0.co;2-g · Cited by 316
Baker, A. H., George, S. J., Zaltsman, A. B., Murphy, G., & Newby, A. C. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690217 · Cited by 286
Valente, P., Fassina, G., Melchiori, A., Masiello, L., Cilli, M., Vacca, A., Onisto, M., Santi, L., Stetler‐Stevenson, W. G., & Albini, A. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980119)75:2<246::aid-ijc13>3.0.co;2-b · Cited by 273
Ahonen, M., Baker, A. H., & Kähäri, V. (1998) · PubMed · Cited by 266
[30] Tissue inhibitors of matrix metalloendopeptidases
Murphy, G., & Willenbrock, F. (1995) · Methods in Enzymology · doi:10.1016/0076-6879(95)48032-3 · Cited by 262
Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells.
Li, G., Fridman, R., & Kim, H.-R. C. (1999) · PubMed · Cited by 256
Apoptosis: Cell death defined by caspase activation
Afshin Samali, A., Zhivotovsky, B., Jones, D. P., Nagata, S., & Orrenius, S. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400520 · Cited by 220
Smith, M. R., Kung, H., Durum, S. K., Colburn, N. H., & Sun, Y. (1997) · Cytokine · doi:10.1006/cyto.1997.0233 · Cited by 188
Guédez, L., Courtemanch, L., & Stetler‐Stevenson, M. (1998) · Blood · doi:10.1182/blood.v92.4.1342 · Cited by 154
Bian, J., Wang, Y., Smith, M. R., Kim, H., Jacobs, C., Jackman, J., Kung, H., Colburn, N. H., & Sun, Y. (1996) · Carcinogenesis · doi:10.1093/carcin/17.9.1805 · Cited by 149
Soloway, P. D., Alexander, C. M., Werb, Z., & Jaenisch, R. (1996) · PubMed · Cited by 125
Localization of the Death Domain of Tissue Inhibitor of Metalloproteinase-3 to the N Terminus
Bond, M., Murphy, G., Bennett, M. R., Amour, A., Knäuper, V., Newby, A. C., & Baker, A. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007929200 · Cited by 118
Zhao, W., Li, H., Yamashita, K., Guo, X., Hoshino, T., Yoshida, S., Shinya, T., & Hayakawa, T. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.9.1147 · Cited by 97
Ritter, L. M., Garfield, S. H., & Thorgeirsson, U. P. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0408 · Cited by 95
Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts
Tummalapalli, C. M., Heath, B. J., & Tyagi, S. C. (2001) · Journal of Cellular Biochemistry · Cited by 89
Tissue inhibitor of metalloproteinase-4 instigates apoptosis in transformed cardiac fibroblasts
Tummalapalli, C. M., Heath, B. J., & Tyagi, S. C. (2001) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010315)80:4<471::aid-jcb1001>3.0.co;2-j · Cited by 88
The molecular control of DNA damage-induced cell death
Coultas, L., & Strasser, A. (2000) · APOPTOSIS · doi:10.1023/a:1009617727938 · Cited by 72
Fas-Mediated Apoptosis in Ewing's Sarcoma Cell Lines by Metalloproteinase Inhibitors
Mitsiades, N., Poulaki, V., Leone, A., & Tsokos, M. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.19.1678 · Cited by 51
Priming in the brain, an immunologically privileged organ, elicits anti-tumor immunity
Fathallah‐Shaykh, H. M., Gao, W., Cho, M., & Herrera, M. A. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980119)75:2<217::aid-ijc9>3.0.co;2-x · Cited by 36
Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa
Jones, S. E., Jomary, C., & Neal, M. J. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00951-1 · Cited by 36
Tissue Inhibitor of Metalloproteinase‐2 Induces Apoptosis in Human T Lymphocytes
Lim, M. S., Guédez, L., Stetler‐Stevenson, W. G., & Stetler‐Stevenson, M. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07715.x · Cited by 35
Baker, A. H., Ahonen, M., & Kähäri, V. (2002) · Advances in experimental medicine and biology · doi:10.1007/0-306-46817-4_41 · Cited by 32
Gaudin, P., Trocmé, C., Berthier, S., Kieffer‐Jaquinod, S., Boutonnât, J., Lamy, C., Surla, A., Garin, J., & Morel, F. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(00)00084-7 · Cited by 23
Matrix metalloproteinases expression in HL-60 promyelocytic leukemia cells during apoptosis
Gazzanelli, G., Luchetti, F., Burattini, S., Mannello, F., Falcieri, E., & Papa, S. (2000) · APOPTOSIS · doi:10.1023/a:1009688831531 · Cited by 16
Self-citation
Cited by
Matrix Metalloproteinases: Role In Arthritis
Burrage, P. (2006) · Frontiers in Bioscience · doi:10.2741/1817 · Cited by 1,292
MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
Gabriely, G., Wurdinger, T., Kesari, S., Esau, C. C., Burchard, J., Linsley, P. S., & Krichevsky, A. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00479-08 · Cited by 888
Is there new hope for therapeutic matrix metalloproteinase inhibition?
Vandenbroucke, R. E., & Libert, C. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4390 · Cited by 832
Multiple roles for MMPs and TIMPs in cerebral ischemia
Cunningham, L. A., Wetzel, M., & Rosenberg, G. A. (2005) · Glia · doi:10.1002/glia.20169 · Cited by 411
Role of muscle endopeptidases and their inhibitors in meat tenderness
Sentandreu, M. A., Coulis, G., & Ouali, A. (2002) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(02)00188-7 · Cited by 366
Metadata
- Authors
- Mannello, F., & Gazzanelli, G.
- Affiliations
- University of Urbino (IT)
- Corresponding author
- Mannello, F.
- ORCID
- Mannello, F.
- Venue
- Apoptosis
- Published
- 2001-12
- Volume
- 6
- Issue
- 6
- Pages
- 479-482
- ISSN
- 1360-8185 (ISSN-L)
- 1573-675X
- OpenAlex
- W309980051
- Cited by
- 185
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 8
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
- Locations
- APOPTOSIS (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- tissue inhibitors of metalloproteinases, matrix metalloproteinases, programmed cell death, extracellular matrix degradation, TIMP-1, TIMP-2, TIMP-3, TIMP-4, TNF-alpha converting enzyme, angiogenesis inhibition, tumor invasion and metastasis
- MeSH terms
- Animals, Humans, Neoplasms, Tumor Necrosis Factor-alpha, Apoptosis, Tissue Inhibitor of Metalloproteinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
