The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Multiple roles for MMPs and TIMPs in cerebral ischemia
Abstract
Matrix metalloproteinases (MMPs) are matrix‐degrading enzymes involved in diverse homeostatic and pathological processes. Several MMPs are expressed within the CNS and serve important normal and pathological functions during development and adulthood. An early and major pathological effect of MMP activity after cerebral ischemia is opening of the blood‐brain barrier (BBB). More recent work demonstrates emerging roles for MMPs and their natural inhibitors, tissue inhibitors of metalloproteinases (TIMPs), in the regulation of neuronal cell death. In addition, MMPs and TIMPs are likely to play important roles during the repair phases of cerebral ischemia, particularly during angiogenesis and reestablishment of cerebral blood flow. This review attempts to elucidate how MMPs and TIMPs may provide detrimental or beneficial actions during the injury and repair processes after cerebral ischemia. These processes will have important implications for therapies using MMP inhibitors in stroke. © 2005 Wiley‐Liss, Inc.
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Cites
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
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How Matrix Metalloproteinases Regulate Cell Behavior
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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
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Regulation of Cell Survival by Secreted Proneurotrophins
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VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain
Zhang, Z. G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C., Bruggen, N. V., & Chopp, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9369 · Cited by 1,296 · cited 1×
“Support for this possibility is the observation that VEGF application at early times after cerebral ischemia, when MMP activity is high, results in augmentation of tissue damage, increased vascular permeability, and increased incidence of hemorrhage (Zhang et al., 2000).”
BackgroundAsahi, M., Wang, X., Mori, T., Sumii, T., Jung, J.-C., Moskowitz, M. A., Fini, M. E., & Lo, E. H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07724.2001 · Cited by 1,004
S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
Gu, Z., Kaul, M., Yan, B., Kridel, S. J., Cui, J., Strongin, A., Smith, J. W., Liddington, R. C., & Lipton, S. A. (2002) · Science · doi:10.1126/science.1073634 · Cited by 950
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Rosenberg, G. A., Cunningham, L. A., Wallace, J., Alexander, S., Estrada, E. Y., Grossetete, M., Razhagi, A., Miller, K., & Gearing, A. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03294-7 · Cited by 388
Self-citation
Cited by
Matrix metalloproteinases (MMPs) in health and disease: an overview
Malemud, C. (2006) · Frontiers in Bioscience · doi:10.2741/1915 · Cited by 705
A new penumbra: transitioning from injury into repair after stroke
Lo, E. H. (2008) · Nature Medicine · doi:10.1038/nm1735 · Cited by 611
Matrix metalloproteinases and their multiple roles in neurodegenerative diseases
Rosenberg, G. A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70016-x · Cited by 594
Self-citationMetalloproteinases: Mediators of Pathology and Regeneration in the CNS
Yong, V. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1807 · Cited by 582
Strategies to advance translational research into brain barriers
Neuwelt, E., Abbott, N. J., Abrey, L., Banks, W. A., Blakley, B., Davis, T., Engelhardt, B., Grammas, P., Nedergaard, M., Nutt, J., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70326-5 · Cited by 474
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Metadata
- Authors
- Cunningham, L. A., Wetzel, M., & Rosenberg, G. A.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2005-04-21
- Volume
- 50
- Issue
- 4
- Pages
- 329-339
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W1970881264
- Cited by
- 411
- References
- 16
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- closed
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