Cited by 456Cardiovascular Function and Risk FactorsCardiovascular Health and Disease PreventionCardiovascular and exercise physiology

The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.

Age-associated Cardiovascular Changes in Health: Impact on Cardiovascular Disease in Older Persons

Lakatta, Edward G.·2002·Heart Failure Reviews

Abstract

In the United States, cardiovascular disease, e.g., atherosclerosis and hypertension, that lead to heart failure and stroke, is the leading cause of mortality, accounting for over 40 percent of deaths in those aged 65 years and above. Over 80 percent of all cardio-vascular deaths occur in the same age group. Thus, age, per se, is the major risk factor for cardiovascular disease. Clinical manifestations and prognosis of these cardiovascular diseases likely become altered in older persons with advanced age because interactions occur between age-associated cardiovascular changes in health and specific pathophysiologic mechanisms that underlie a disease. A fundamental understanding of age-associated changes in cardiovascular structure and function ranging in scope from humans to molecules is required for effective and efficient prevention and treatment of cardiovascular disease in older persons. A sustained effort over the past two decades has been applied to characterize the multiple effects of aging in health on cardiovascular structure and function in a single study population, the Baltimore Longitudinal Study on Aging. In these studies, community dwelling, volunteer participants are rigorously screened to detect both clinical and occult cardiovascular disease and characterized with respect to lifestyle, e.g. exercise habits, in an attempt to deconvolute interactions among lifestyle, cardiovascular disease and the aging process in health. This review highlights some specific changes in resting cardiovascular structure and function and cardiovascular reserve capacity that occur with advancing age in healthy humans. Observations from relevant experiments in animal models have been integrated with those in humans to provide possible mechanistic insight.

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Crossref · 10.1023/a:1013797722156

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Research works printed but not linked: 6

  1. Guyton JR, Lindsay KL, Dao DT. Comparison of aortic intima and inner media in young adult versus aging rats. Am J Pathol 1983;111:234-246.
  2. Jenkins GM, Crow MT, Bilato C, Li Z, Ryu W-S, Nater C, Froehlich J, Lakatta EG, Cheng L. The role of MMP-2 in neointima formation following balloon injury in the rat. Circulation 1997 (in press).
  3. McCaffrey TA, Nicholson AC, Szabo PE, Weksler ME, Weksler BB. Aging and atherosclerosis: the increased proliferation of arterial smooth muscle cells isolated from old rats is associated with increased platelet derived growth factor-like activity. J Exp Med 1988;167:163-174. · DOI
  4. Gerstenblith G, Fredricksen J, Yin FCP, et al. Echocardiographic assessment of a normal adult aging population. Circ 1977;56:273. · DOI
  5. National Center for Health Statistics Vital statistics of the United States, 1988, Vol. II Mortality, Part A, Tables 1-27, 1-129. National Center for Health Statistics, Rockville, MD, 1991.
  6. Lakatta EG, Weisfeldt ML, Gerstenblith G. The aging heart: Structure, function, and disease. In: E. Braunwald ed. Heart Disease. A Textbook of Cardiovascular Medicine, 5th edition. WB Saunders, NY. Chapter 50, p 1687, 1996.

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Metadata

Authors
Lakatta, E. G.
Affiliations
National Institutes of Health (US)
Corresponding author
Lakatta, Edward G.
Venue
Heart Failure Reviews
Published
2002-01
Volume
7
Issue
1
Pages
29-49
ISSN
  • 1382-4147 (ISSN-L)
  • 1573-7322
OpenAlex
W1577665082
Cited by
445
References
72
Citations by year
2026: 13 · 2025: 23 · 2024: 21 · 2023: 14 · 2022: 13 · 2021: 29 · 2020: 21 · 2019: 12 · 2018: 12 · 2017: 17 · 2016: 14 · 2015: 18 · 2014: 38 · 2013: 31 · 2012: 25
FWCI
6.76
Type
journal article
Language
en
Open access
closed
Locations
  • Heart Failure Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
cardiovascular aging, cardiovascular disease in older adults, atherosclerosis, hypertension, heart failure, stroke, exercise habits, cardiovascular structure and function, animal models of aging
MeSH terms
Aged, Aging, Cardiovascular Diseases, Cardiovascular System, Hemodynamics, Humans, Risk Factors

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