Auxin-responsive gene expression: genes, promoters and regulatory factors
Abstract
A molecular approach to investigate auxin signaling in plants has led to the identification of several classes of early/primary auxin response genes. Within the promoters of these genes, cis elements that confer auxin responsiveness (referred to as auxin-response elements or AuxREs) have been defined, and a family of trans-acting transcription factors (auxin-response factors or ARFs) that bind with specificity to AuxREs has been characterized. A family of auxin regulated proteins referred to as Aux/IAA proteins also play a key role in regulating these auxin-response genes. Auxin may regulate transcription on early response genes by influencing the types of interactions between ARFs and Aux/IAAs.
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Binding of the hormone to a receptor activates an F-box protein-containing SCF E3 ligase complex, which mediates ubiquitination and subsequent degradation of a transcriptional repressor, ultimately leading to changes in transcription of a specific set of genes.
“Briefly, binding of the hormone to a receptor activates an F-box protein-containing SCF E3 ligase complex, which mediates ubiquitination and subsequent degradation of a transcriptional repressor. Ultimately, this leads to changes in transcription of a specific set of genes (Hagen and Guilfoyle, 2002; Hartweck, 2008; Memelink, 2009).”
From Shaping plant architecture (2015) · cites this paper as Hagen and Guilfoyle, 2002
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The F-box protein TIR1 is an auxin receptor
Dharmasiri, N., Dharmasiri, S., & Estelle, M. (2005) · Nature · doi:10.1038/nature03543 · Cited by 2,083 · see citing works
Mechanism of auxin perception by the TIR1 ubiquitin ligase
Tan, X., Calderon-Villalobos, L. I. A., Sharon, M., Zheng, C., Robinson, C. V., Estelle, M., & Zheng, N. (2007) · Nature · doi:10.1038/nature05731 · Cited by 1,688 · see citing works
Tatematsu, K., Kumagai, S., Muto, H., Sato, A., Watahiki, M. K., Harper, R. M., Liscum, E., & Yamamoto, K. T. (2004) · The Plant Cell · doi:10.1105/tpc.018630 · Cited by 431 · see citing works
Auxin-related gene families in abiotic stress response in Sorghum bicolor
Wang, S., Bai, Y., Shen, C., Wu, Y., Zhang, S., Jiang, D., Guilfoyle, T. J., Chen, M., & Qi, Y. (2010) · Functional & Integrative Genomics · doi:10.1007/s10142-010-0174-3 · Cited by 297 · see citing works
Self-citationTeichmann, T., & Muhr, M. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00233 · Cited by 228 · see citing works
“Ultimately, this leads to changes in transcription of a specific set of genes (Hagen and Guilfoyle, 2002; Hartweck, 2008; Memelink, 2009).”
BackgroundAuxin Perception--Structural Insights
Calderon-Villalobos, L. I., Tan, X., Zheng, N., & Estelle, M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005546 · Cited by 177 · see citing works
OsIAA18, an Aux/IAA transcription factor gene, is involved in Salt and drought tolerance in rice
Wang, F., Niu, H., Xin, D., Long, Y., Wang, G., Liu, Z., Li, G., Zhang, F., Qi, M., Ye, Y., et al. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.738660 · Cited by 82 · see citing works
Stone, B. B., Esmon, C. A., & Liscum, E. (2005) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)66007-3 · Cited by 13 · see citing works
- Authors
- Hagen, G., & Guilfoyle, T.
- Affiliations
- University of Missouri (US)
- ORCID
- Guilfoyle, Tom
- Venue
- Plant Molecular Biology
- Published
- 2002-06
- Volume
- 49
- Issue
- 3-4
- Pages
- 373-385
- ISSN
- 0167-4412 (ISSN-L)
- 1573-5028
- OpenAlex
- W1589807584
- Cited by
- 1,262
- References
- 0
- Citations by year
- 2026: 32 · 2025: 48 · 2024: 80 · 2023: 59 · 2022: 71 · 2021: 76 · 2020: 80 · 2019: 79 · 2018: 54 · 2017: 63 · 2016: 49 · 2015: 52 · 2014: 52 · 2013: 69 · 2012: 47
- FWCI
- 49.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Plant Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- University of Missouri
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Keywords
- auxin signaling, auxin response genes, auxin response elements, auxin response factor, Aux/IAA proteins, cis-regulatory elements, transcriptional regulation, trans-acting transcription factors, plant gene regulation
- MeSH terms
- Base Sequence, Indoleacetic Acids, Plants, Promoter Regions, Genetic, Regulatory Sequences, Nucleic Acid, Genes, Plant, Gene Expression Regulation, Plant
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