Cited by 499Heme Oxygenase-1 and Carbon MonoxideHemoglobin structure and functionNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.

Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance

Open access

Ryter, Stefan W., Otterbein, Leo E., Morse, Danielle, Choi, Augustine M.K.·2002·Molecular and Cellular Biochemistry

DOI 10.1023/a:1015957026924PMC PMC7101540

Open this paper in CoChat — free account Open PDF

Abstract

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as constitutive (HO-2, HO-3) and inducible isoforms (HO-1), the latter which responds to regulation by multiple stress-stimuli. HO-1 confers protection in vitro and in vivo against oxidative cellular stress. Although the redox active compounds that are generated from HO activity (i.e. iron, biliverdin-IXalpha, and bilirubin-IXa) potentially modulate oxidative stress resistance, increasing evidence points to cytoprotective roles for CO. Though not reactive, CO regulates vascular processes such as vessel tone, smooth muscle proliferation, and platelet aggregation, and possibly functions as a neurotransmitter. The latter effects of CO depend on the activation of guanylate cyclase activity by direct binding to the heme moiety of the enzyme, stimulating the production of cyclic 3':5'-guanosine monophosphate. CO potentially interacts with other intracellular hemoprotein targets, though little is known about the functional significance of such interactions. Recent progress indicates that CO exerts novel anti-inflammatory and anti-apoptotic effects dependent on the modulation of the p38 mitogen activated protein kinase (MAPK)-signaling pathway. By virtue of these effects, CO confers protection in oxidative lung injury models, and likely plays a role in HO-1 mediated tissue protection.

Integrity signals

Registry

Crossref · 10.1023/a:1015957026924

Cites

214 of 214 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Bilirubin Is an Antioxidant of Possible Physiological Importance
Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1987) · Science · doi:10.1126/science.3029864 · Cited by 3,502
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
Han, J., Lee, J. D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,647
THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
Maines, M. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,489
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153
Self-citation
Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction
Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J., & Gusovsky, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10689 · Cited by 1,924
The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.
Tenhunen, R., Marver, H. S., & Schmid, R. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.61.2.748 · Cited by 1,803
Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications
Maines, M. D. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.10.3290025 · Cited by 1,707
Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606
Carbon Monoxide: a Putative Neural Messenger
Verma, A. M., Hirsch, D. B., Glatt, C. E., Ronnett, G. V., & Snyder, S. H. (1993) · Science · doi:10.1126/science.7678352 · Cited by 1,563

Show all 209 references

Research works printed but not linked: 3

Borger DR, Essig DA: Induction of HSP 32 gene in hypoxic cardiomyocytes is attenuated by treatment with N-acetyl-L-cysteine. Am J Physiol 274: H965–H973, 1998
Camhi SL, Alam J, Wiegand GW, Chin BY, Choi AM: Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers: Role of reactive oxygen intermediates and AP-1. Am J Respir Cell Mol Biol 18: 226–234, 1998 · DOI
Camhi SL, Alam J, Otterbein L, Sylvester SL, Choi AM: Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am J Respir Cell Mol Biol 13: 387–398, 1995 · DOI

Sorted by citations

Items 301–400 of 499

Crystal structures of the G139A, G139A?NO and G143H mutants of human heme oxygenase-1. A finely tuned hydrogen-bonding network controls oxygenase versus peroxidase activity
Lad, L., Koshkin, A., de Montellano, P. R. O., & Poulos, T. L. (2005) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-004-0620-6 · Cited by 20
Therapeutic approaches to diabetic cardiomyopathy: Targeting the antioxidant pathway
Arad, M., Waldman, M., Abraham, N. G., & Hochhauser, E. (2020) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2020.106454 · Cited by 20
Efficacy of a novel water-soluble curcumin derivative versus sildenafil citrate in mediating erectile function
Zaahkouk, A. M., Aziz, M. T. A., Rezq, A. M., Atta, H. M., Fouad, H. H., Ahmed, H. H., Sabry, D., & Yehia, M. (2014) · International Journal of Impotence Research · doi:10.1038/ijir.2014.24 · Cited by 20
Hemin induction of HO-1 protects against LPS-induced septic ileus
Bortscher, S., Chang, J., Vilz, T. O., Schäfer, N., Sommer, N. P., Wehner, S., Kalff, J. C., & Overhaus, M. (2012) · Journal of Surgical Research · doi:10.1016/j.jss.2012.07.064 · Cited by 20
No Nitric Oxide for HO-1 from Sodium Nitroprusside
Schröder, H. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.023416 · Cited by 20
A Meta-analysis of the Association of Exhaled Carbon Monoxide on Asthma and Allergic Rhinitis
Yu, S., Ruxin, Z., Yingjian, C., Jianqiu, C., Yanshen, W., & Li, G. (2010) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-009-8195-1 · Cited by 20
Sensing Hypoxia by Mitochondria: A Unifying Hypothesis Involving S-Nitrosation
Ullrich, V., & Schildknecht, S. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4788 · Cited by 19
Gastroprotective effect of ghrelin against indomethacin-induced gastric injury in rats: possible role of heme oxygenase-1 pathway
Allam, M. M., & El-Gohary, O. A. (2017) · General Physiology and Biophysics · doi:10.4149/gpb_2016056 · Cited by 19
The CO donor CORM‐ 2 inhibits LPS ‐induced vascular cell adhesion molecule‐1 expression and leukocyte adhesion in human rheumatoid synovial fibroblasts
Chi, P., Chuang, Y., Chen, Y., Lin, C., Hsiao, L., & Yang, C. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12680 · Cited by 19
Anti-inflammatory activity of Bambusae Caulis in Taeniam through heme oxygenase-1 expression via Nrf-2 and p38 MAPK signaling in macrophages
Jin, G. H., Park, S. Y., Kim, E., Ryu, E. Y., Kim, Y. H., Park, G., & Lee, S. J. (2012) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2012.05.001 · Cited by 19
Heart failure increases protein expression and enzymatic activity of heme oxygenase-1 in the lung
LAM, C., Croatt, A. J., RICHARDSON, D., Nath, K. A., & Katušić, Z. S. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.09.001 · Cited by 19
Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines
Kim, D., Cho, K. H., Ko, W., Yoon, C., Sohn, J., Yim, J. H., Kim, Y., & Oh, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040529 · Cited by 19
Effect of isoflavone administration on age-related hepatocyte changes in old ovariectomized femal Wistar rats
Castillo, C., Salazar, V., Ariznavarreta, C., Vara, E., & Tresguerres, J. A. F. (2005) · Phytomedicine · doi:10.1016/j.phymed.2005.03.012 · Cited by 19
Effect of Recombinant Human Growth Hormone on Age-Related Hepatocyte Changes in Old Male and Female Wistar Rats
Castillo, C., Salazar, V., Ariznavarreta, C., Vara, E., & Tresguerres, J. A. F. (2004) · Endocrine · doi:10.1385/endo:25:1:33 · Cited by 19
Mechanisms involved in antinociception induced by a polysulfated fraction from seaweed Gracilaria cornea in the temporomandibular joint of rats
Coura, C. O., Chaves, H. V., do Val, D. R., Vieira, L. V., Silveira, F. D., Lopes, F. M. L. D. S., Gomes, F. I. F., Frota, A. F., Souza, R. B., Clemente‐Napimoga, J. T., et al. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.01.017 · Cited by 18
Protective effects of heme oxygenase‐1 against cyclophosphamide‐induced haemorrhagic cystitis in rats
Matsuoka, Y., Masuda, H., Yokoyama, M., & Kihara, K. (2007) · British Journal of Urology · doi:10.1111/j.1464-410x.2007.07111.x · Cited by 18
Lipocalins and Structurally Related Ligand-Binding Proteins
Kayser, H. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00056-9 · Cited by 18
Evolution of P450 Monooxygenases toward Formation of Transient Channels and Exclusion of Nonproductive Gases
Ebert, M. C. C. J. C., Dürr, S., Houle, A. A., Lamoureux, G., & Pelletier, J. N. (2016) · ACS Catalysis · doi:10.1021/acscatal.6b02154 · Cited by 18
Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation
Sheng, X.-J., Tu, H.-J., Chien, W., Kang, K., Lu, D., Liou, H., Lee, M., & Fu, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183076 · Cited by 18
Renoprotective effects of montelukast in an experimental model of cisplatin nephrotoxicity in rats
Gad, A. M., El‐Raouf, O. M. A., El‐Sayeh, B. M., Fawzy, H. M., & Abdallah, D. M. (2017) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21979 · Cited by 18
CO-trapping Site in Heme Oxygenase Revealed by Photolysis of its CO-bound Heme Complex: Mechanism of Escaping from Product Inhibition
Sugishima, M., Sakamoto, H., Noguchi, M., & Fukuyama, K. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.05.048 · Cited by 18
Lycopene improves autophagy and attenuates carbon tetrachloride-induced hepatic fibrosis in rats
Li, W., Jiang, Y., Yu, T.-T., Hao, W., & Wang, G. (2023) · Croatian Medical Journal · doi:10.3325/cmj.2023.64.243 · Cited by 17
Involvement of heme oxygenase-1 in β-cyclodextrin–hemin complex-induced cucumber adventitious rooting process
Lin, Y.-T., Li, M., Huang, L., Shen, W., & Ren, Y. (2012) · Plant Cell Reports · doi:10.1007/s00299-012-1270-8 · Cited by 17
The Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1α–Heme Oxygenase 1 Axis, a Powerful Antioxidative Pathway with Potential to Attenuate Diabetic Cardiomyopathy
Waldman, M., Arad, M., Abraham, N. G., & Hochhauser, E. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7989 · Cited by 17
Low dose of carbon monoxide intraperitoneal injection provides potent protection against GalN/LPS‐induced acute liver injury in mice
Wen, Z., Liu, Y., Li, F., & Wen, T. (2012) · Journal of Applied Toxicology · doi:10.1002/jat.2806 · Cited by 17
T cell epitope definition by differential mass spectrometry: Identification of a novel, immunogenic HLA‐B8 ligand directly from renal cancer tissue
Flad, T., Mueller, L., Dihazi, H., Grigorova, V., Bogumil, R., Beck, A., Lee‐Thedieck, C., Muller, G. A., Kalbacher, H., & Müller, C. A. (2005) · PROTEOMICS · doi:10.1002/pmic.200500099 · Cited by 17
Alterations in the glutathione metabolism could be implicated in the ischemia-induced small intestinal cell damage in horses
Marañón, G., Manley, W., Cayado, P., Garcı́a, C., de la Muela, M. S., & Vara, E. (2009) · BMC Veterinary Research · doi:10.1186/1746-6148-5-10 · Cited by 17
Anti-oxidative Activity of Hydrolysate from Rice Bran Protein in HepG2 Cells
Moritani, C., Kawakami, K., Fujita, A., Kawakami, K., Hatanaka, T., & Tsuboi, S. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00971 · Cited by 17
Mechanisms of Drug Action
Proekt, A., & Hemmings, H. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-48110-6.00001-6 · Cited by 17
Intravenous infusion of haptoglobin for the prevention of adverse clinical outcome in Sickle Cell Disease
Quimby, K. R., Hambleton, I. R., & Landis, R. C. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.06.023 · Cited by 16
Novel Water-soluble Curcumin Derivative Mediating Erectile Signaling
Aziz, M. T. A., Asmer, M. F. E., Rezq, A. M., Kumosani, T., Mostafa, S., Mostafa, T., Atta, H. M., Wassef, M. A. A., Fouad, H. H., Rashed, L. A., et al. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01543.x · Cited by 16
Anti-inflammatory effect of methanol extract fromErigeron CanadensisL. may be involved with upregulation of heme oxygenase-1 expression and suppression of NFκB and MAPKs activation in macrophages
Sung, J., Sung, M.-S., Kim, Y., Ham, H., Jeong, H., & Lee, J. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.4.352 · Cited by 16
Enhanced expression of heme oxygenase-1 in the locus coeruleus can be associated with anxiolytic-like effects
Cazuza, R. A., Pol, O., & Leite‐Panissi, C. R. A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.007 · Cited by 16
Temporal inhibition of mouse mammary gland cancer metastasis by CORM-A1 and DETA/NO combination therapy
Porshneva, K., Papiernik, D., Psurski, M., Łupicka‐Słowik, A., Matkowski, R., Ekiert, M., Nowak, M., Jarosz, J., Banach, J., Milczarek, M., et al. (2019) · Theranostics · doi:10.7150/thno.31461 · Cited by 16
Resistance to Nitric Oxide-induced Necrosis in Heme Oxygenase-1 Overexpressing Pulmonary Epithelial Cells Associated with Decreased Lipid Peroxidation
Reiter, T. A., Pang, B., Dedon, P. C., & Demple, B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602634200 · Cited by 16
Effects of Cyclopentenone Prostaglandins on the Expression of Heme Oxygenase‐1 in MCF‐7 Cells
Kim, E. H., Kim, D., Na, H., & Surh, Y. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.061 · Cited by 16
A mitochondria-targeted fluorescent probe for imaging of endogenous carbon monoxide in living cells
Yi, M., Zhang, N., Liu, X., Liu, J., Zhang, X., Wei, Y., & Shangguan, D. (2023) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2023.122377 · Cited by 15
Role of heme oxygenase-1 in spermidine-induced alleviation of salt toxicity during alfalfa seed germination
Zhu, K., Zhang, J., Cui, W., Jin, Q., Samma, M. K., & Shen, W. (2013) · Plant and Soil · doi:10.1007/s11104-013-1964-x · Cited by 15
Role of Heme Oxygenase in Gastrointestinal Epithelial Cells
Akagi, R. (2022) · Antioxidants · doi:10.3390/antiox11071323 · Cited by 15
Mechanism of action and therapeutic potential of dimethyl fumarate in ischemic stroke
Owjfard, M., Karimi, F., Mallahzadeh, A., Nabavizadeh, S. A., Namavar, M. R., Saadi, M. I., Hooshmandi, E., Salehi, M. S., Zafarmand, S. S., Bayat, M., et al. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25202 · Cited by 15
Divergent Molecular Mechanisms Underlay CO- and CORM-2-Induced Relaxation of Corpora Cavernosa
Decaluwé, K., Pauwels, B., Boydens, C., & de Voorde, J. V. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02831.x · Cited by 15
Randomized, Controlled Trial of Early Intravenous Nutrition for Prevention of Neonatal Jaundice in Term and Near‐term Neonates
Makay, B. B., Duman, N., Özer, E. A., Kumral, A., Yeşilırmak, D. C., & Özkan, H. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31802b31f2 · Cited by 15
Carboxyhemoglobin and Methemoglobin in Asthma
Naples, R. F., Laskowski, D., McCarthy, K. J., Mattox, E., COMHAIR, S. A. A., & ERZURUM, S. C. (2015) · Lung · doi:10.1007/s00408-015-9686-x · Cited by 15
Bilin-metabolizing enzymes: site-specific reductions catalyzed by two different type of enzymes
Sugishima, M., Wada, K., Unno, M., & Fukuyama, K. (2019) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2019.03.005 · Cited by 15
The development of a hemicyanine-based ratiometric CO fluorescent probe with a long emission wavelength and its applications for imaging CO in vitro and in vivo
Zhang, Y., Kong, X., Tang, Y., Li, M., Yin, Y., & Lin, W. (2020) · New Journal of Chemistry · doi:10.1039/d0nj00677g · Cited by 15
Heme Oxygenase-2 Modulates Early Pathogenesis after Traumatic Injury to the Immature Brain
Yoneyama-Sarnecky, T., Olivas, A. D., Azari, S., Ferriero, D. M., Manvelyan, H. M., & Noble‐Haeusslein, L. J. (2010) · Developmental Neuroscience · doi:10.1159/000258700 · Cited by 15
A systematic review of preclinical studies on the efficacy of taurine for the treatment of rheumatoid arthritis
Mahdavi, A. M., & Javadivala, Z. (2021) · Amino Acids · doi:10.1007/s00726-021-02988-8 · Cited by 14
Proanthocyanidins regulate the Nrf2/ARE signaling pathway and protect neurons from cypermethrin-induced oxidative stress and apoptosis
Zhou, L., Chang, J., Zhao, W., & Gao, Y. (2021) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2021.104898 · Cited by 14
Biological Effects and Mechanisms of Taurine in Various Therapeutics
Sharma, S., Sahoo, B. M., & Banik, B. K. (2023) · Current Drug Discovery Technologies · doi:10.2174/1570163820666230525101353 · Cited by 14
Pharmacological Significance of Heme Oxygenase 1 in Prostate Cancer
Ben‐Eltriki, M., Gayle, E. J., Walker, N., & Deb, S. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45050273 · Cited by 14
Molecular signalling of a novel curcumin derivative versus Tadalafil in erectile dysfunction
Aziz, M. T. A., Rezq, A. M., Atta, H. M., Fouad, H. H., Zaahkouk, A. M., Ahmed, H. H., Sabry, D., & Yehia, H. M. (2014) · Andrologia · doi:10.1111/and.12309 · Cited by 14
Protective Effects of Bilirubin Against Cyclophosphamide Induced Hemorrhagic Cystitis in Rats
Matsuoka, Y., Masuda, H., Yokoyama, M., & Kihara, K. (2008) · The Journal of Urology · doi:10.1016/j.juro.2007.10.031 · Cited by 14
Role of HMOX1 Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia
Bukowska-Straková, K., Włodek, J., Pitera, E., Kozakowska, M., Konturek-Cieśla, A., Cieśla, M., Gońka, M., Nowak, W. N., Wieczorek, A., Pawińska-Wąsikowska, K., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22030988 · Cited by 14
What role does the heme— heme oxygenase—carbon monoxide system play in vasoregulation?
Marks, G. S., Brien, J. F., & Nakatsu, K. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00317.2003 · Cited by 14
Sickle Cell Disease at the Dawn of the Molecular Era
Abboud, M. R., & Musallam, K. M. (2009) · Hemoglobin · doi:10.3109/03630260903347617 · Cited by 14
Cardiopulmonary Bypass Increases Endogenous Carbon Monoxide Production
Schober, P. R., Kalmanowicz, M., Schwarte, L. A., & Loer, S. A. (2009) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2009.03.001 · Cited by 13
PAS kinase deficiency reduces aging effects in mice
Dongil, P., Pérez-García, A., Hurtado-Carneiro, V., Herrero-de-Dios, C. M., Álvarez, E., & Sanz, C. (2020) · Aging · doi:10.18632/aging.102745 · Cited by 13
Plasma heme-induced renal toxicity is related to a capillary rarefaction
Tabibzadeh, N., Estournet, C., Placier, S., Perez, J., Bilbault, H., Girshovich, A., Vandermeersch, S., Jouanneau, C., Letavernier, E., Hammoudi, N., et al. (2017) · Scientific Reports · doi:10.1038/srep40156 · Cited by 13
Protective Effects of Sweet Orange, Unshiu Mikan, and Mini Tomato Juice Powders on t-BHP-Induced Oxidative Stress in HepG2 Cells
Jannat, S., Ali, M. Y., Kim, H., Jung, H. A., & Choi, J. S. (2016) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2016.21.3.208 · Cited by 13
A positive feedback regulation of Heme oxygenase 1 by CELF1 in cardiac myoblast cells
Liu, Y., Wang, H., Wang, J., Wei, B. K., Zhang, X., Zhang, M., Cao, D., Dai, J., Wang, Z., Nyirimigabo, E., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.11.006 · Cited by 13
Effect of S-adenosylmethionine on Age-induced Hepatocyte Damage in Old Wistar Rats
Castillo, C., Salazar, V., Ariznavarreta, C., Fossati, M., Tresguerres, J. A. F., & Vara, E. (2005) · Biogerontology · doi:10.1007/s10522-005-4806-2 · Cited by 13
Redox System Dysfunction as a Key Mechanism in Autism Spectrum Disorder Pathogenesis
de Oliveira, C. A., Iorio, E. L., & Espíndola, F. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209850 · Cited by 12
Melatonin protects against burn-induced hepatic oxidative injury by inducing HO-1 via the Nrf2 pathway
Bekyarova, G. Y., Tzaneva, M. A., & Hristova, M. (2015) · Veterinární Medicína · doi:10.17221/8530-vetmed · Cited by 12
Forsythia Fruit Prevents Fulminant Hepatitis in Mice and Ameliorates Inflammation in Murine Macrophages
Jeong, Y. H., Hwang, Y., Kim, T. I., Oh, Y.-C., & Yeul, J. (2021) · Nutrients · doi:10.3390/nu13082901 · Cited by 12
Membrane-Bound Redox Enzyme Cytochrome bd-I Promotes Carbon Monoxide-Resistant Escherichia coli Growth and Respiration
Nastasi, M. R., Borisov, V. B., & Forte, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021277 · Cited by 12
Involvement of Heme Oxygenase-1 Induction in the Cytoprotective and Immunomodulatory Activities ofViola patriniiin Murine Hippocampal and Microglia Cells
Li, B., Lee, D., Choi, H.-G., Kim, K.-S., Jeong, G., An, R. B., & Kim, Y. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/128019 · Cited by 12
Retracted
Prevention of Hyperuricemia by Clerodendrum trichotomum Leaf Extract in Potassium Oxonate-Induced Mice
Jang, M. G., Song, H., Kim, J. H., Oh, J. M., Park, J. Y., Ko, H., Hur, S., & Kim, S. (2020) · Development & Reproduction · doi:10.12717/dr.2020.24.2.89 · Cited by 12
Beneficial effects of early (but not late) intervention of heme oxygenase-1 on bleomycin-induced pulmonary fibrosis in mice
Jin, C., Zhou, D., & Lv, F. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.11.010 · Cited by 12
The Effectiveness of Oral Tin Mesoporphyrin Prophylaxis in Reducing Bilirubin Production after an Oral Heme Load in a Transgenic Mouse Model
DeSandre, G. H., Wong, R. J., Morioka, I., Contag, C. H., & Stevenson, D. K. (2005) · Neonatology · doi:10.1159/000088717 · Cited by 12
Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers
Pinto, R. V., Pinto, M. L., & Serre, C. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202404553 · Cited by 11
Protective Effects of Curcumin and its Analogues via the Nrf2 Pathway in Metabolic Syndrome
Rajabi, S., Darroudi, M., Naseri, K., Farkhondeh, T., & Samarghandian, S. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230510101150 · Cited by 11
Spironolactone and Enalapril Differentially Up-Regulate the Expression of VEGF and Heme Oxygenase-1 in the Neonatal Rat Kidney
Yim, H. E., Kim, J. H., Yoo, K. H., Bae, I. S., Hong, Y. S., & Lee, J. W. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e3182114c38 · Cited by 11
The effects of gasotransmitters on bronchopulmonary dysplasia
Lin, H. P., & Wang, X. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172983 · Cited by 11
Targeting endogenous gaseous signaling molecules as novel host-directed therapies against tuberculosis infection
Gautam, K., Negi, S., & Saini, V. (2021) · Free Radical Research · doi:10.1080/10715762.2021.1892091 · Cited by 11
Anti-Inflammatory Effect of Erigeron annuus L. Flower Extract through Heme Oxygenase-1 Induction in RAW264.7 Macrophages
Sung, M.-S., 김영화, 최용민, 함현미, Jeong, H.-S., & Lee, J. (2011) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2011.40.11.1507 · Cited by 11
Valsartan decreases neointimal hyperplasia in balloon-injured rat aortic arteries by upregulating HO-1 and inhibiting angiotensin II type 1 receptor
Li, Y., Wang, Q., Xu, Q., Cai, S., Zhou, J., Ren, B., Sun, T., Liu, X., & Yu, H. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.06.021 · Cited by 10
TISSUE-DEPENDENT INDUCTION OF HEME OXYGENASE-1 AND METALLOTHIONEIN-1/2 BY METHYL METHANESULFONATE
Ashino, T., Ozawa, S., Numazawa, S., & Yoshida, T. (2003) · The Journal of Toxicological Sciences · doi:10.2131/jts.28.181 · Cited by 10
Heme oxygenase 1 affects granulopoiesis in mice through control of myelocyte proliferation
Bukowska-Straková, K., Cieśla, M., Szade, K., Nowak, W. N., Straka, R., Szade, A., Tyszka‐Czochara, M., Najder, K., Konturek-Cieśla, A., Siedlar, M., et al. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.10.018 · Cited by 10
Recent Advances in the Understanding of the Reaction Chemistries of the Heme Catabolizing Enzymes HO and BVR Based on High Resolution Protein Structures
Sugishima, M., Wada, K., & Fukuyama, K. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867326666181217142715 · Cited by 10
Use of Carboxyhemoglobin as an Early Sign of Oxygenator Dysfunction in Patients Supported by Extracorporeal Membrane Oxygenation
Cousin, V. L., Giraud, R., Assouline, B., Silva, I. N., & Bendjelid, K. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.893642 · Cited by 10
Diesel exhaust particles (DEP) pre-exposure contributes to the anti-oxidant response impairment in hCMEC/D3 during post-oxygen and glucose deprivation damage
Farina, F., Lonati, E., Brambilla, A., Magro, R. D., Milani, C., Botto, L., Sancini, G., Palestini, P., & Bulbarelli, A. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.04.003 · Cited by 10
Carboxyhemoglobin levels in children during extracorporeal membrane oxygenation support: a retrospective study
Kimura, S., Gelbart, B., Chiletti, R., Stephens, D., & Butt, W. W. (2021) · Perfusion · doi:10.1177/02676591211027776 · Cited by 10
Effect of Growth Hormone and Estrogen Administration on Hepatocyte Alterations in Old Ovariectomized Female Wistar Rats
Castillo, C., Salazar, V., Ariznavarreta, C., Vara, E., & Tresguerres, J. A. F. (2005) · Endocrine · doi:10.1385/endo:26:1:011 · Cited by 10
Involvement of haem oxygenase-1 in hydrogen peroxide-induced lateral root formation in tomato
Cao, Z., Fang, T., Chen, M., Li, J., Shen, W., & Huang, L. (2013) · Acta Physiologiae Plantarum · doi:10.1007/s11738-013-1472-x · Cited by 9
Construction of a potentially functional lncRNA-miRNA-mRNA network in sepsis by bioinformatics analysis
Zheng, L., Ye, J.-Q., Li, H.-F., & Liu, Q. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1031589 · Cited by 9
Construction of recombinant adenovirus vector containing a modified gene that codes for human hypoxia-inducible factor-1α without oxygen-dependent degradation domain
Wei, L., Lu, J., Li, F., Li, S., Shan, J., & Li, Y. (2009) · Plasmid · doi:10.1016/j.plasmid.2009.09.002 · Cited by 9
Human Heme Oxygenase-1 Efficiently Catabolizes Heme in the Absence of Biliverdin Reductase
Reed, J. R., Huber, W. J., & Backes, W. L. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.034777 · Cited by 9
Carbon monoxide poisoning: A problem uniquely suited to a medicinal inorganic chemistry solution
Parker, A. L., & Johnstone, T. C. (2023) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2023.112453 · Cited by 9
Carbon Monoxide Transport and Actions in Blood and Tissues
Thom, S. R. (2011) · Comprehensive physiology · doi:10.1002/cphy.c091005 · Cited by 9
Neuroprotective Benzyl Benzoate Glycosides from Disporum viridescens Roots in HT22 Hippocampal Neuronal Cells
Cho, N., Yang, H., Lee, M., Huh, J., Kim, H.-W., Kim, H.-P., & Sung, S. H. (2013) · Journal of Natural Products · doi:10.1021/np400676b · Cited by 9
Cardioprotection by AN-7, a prodrug of the histone deacetylase inhibitor butyric acid: Selective activity in hypoxic cardiomyocytes and cardiofibroblasts
Nudelman, V., Zahalka, M. A., Nudelman, A., Rephaeli, A., & Kessler‐Icekson, G. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173255 · Cited by 9
Guggulsterone protects against lipopolysaccharide-induced inflammation and lethal endotoxemia via heme oxygenase-1
Kweon, B., Kim, D.-U., Oh, J.-Y., Bae, G., & Park, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111073 · Cited by 8
Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice
Jahn, N., Lamberts, R. R., Busch, C. J., Vöelker, M. T., Busch, T., Simmelink, M. J. A., Teunissen, C. E., Oswald, D. D., Loer, S. A., Kaisers, U. X., et al. (2015) · Respiratory Research · doi:10.1186/s12931-015-0274-7 · Cited by 8
Possible contribution of endogenous carbon monoxide to the development of allergic rhinitis in guinea pigs
Yu, S., Ruxin, Z., Yinjian, C., Jianqiu, C., Chunsheng, Z., Jiangfeng, T., & Li, G. (2008) · Journal of Inflammation · doi:10.1186/1476-9255-5-23 · Cited by 8
Modulation of heme oxygenase/carbon monoxide system affects the inhibitory neurotransmission involved in gastrointestinal motility of streptozotocin‐treated diabetic rats
Piepoli, A. L., Salvatore, G. D., Lemoli, M., Benedictis, L. D., Mitolo‐Chieppa, D., & Salvia, M. A. D. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01193.x · Cited by 8
Acerogenin C from Acer nikoense exhibits a neuroprotective effect in mouse hippocampal HT22 cell lines through the upregulation of Nrf-2/HO-1 signaling pathways
Kim, N.-T., Lee, D., Chowdhury, A., Lee, H., Cha, B., Woo, J., Woo, E. R., & Jang, J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6682 · Cited by 8
Endogenous Cytoprotective Mechanisms
Wong, H. R. (2005) · Neuroimmune biology · doi:10.1016/s1567-7443(05)80008-0 · Cited by 8
Hepatoprotective Effects of Xylose-Taurine Reduced Against Hydrogen Peroxide-Induced Oxidative Stress in Cultured Hepatocytes
Park, S. Y., Ahn, C., Chang, K. J., Kim, S. H., Lee, W., Um, J. H., Han, E. J., Jeon, Y., Cheong, S. H., & Ahn, G. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1079-2_48 · Cited by 8
Melatonin Ameliorates Burn-Induced Liver Injury by Modulation of Nrf2 and Nf- kB Signaling Pathways
Bekyarova, G. Y. (2015) · SOJ Immunology · doi:10.15226/soji/3/2/00128 · Cited by 8
New signaling routes for an old drug: lipoxin A4 might mediate heme oxygenase-1 induction by aspirin. Focus on “Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells”
Schröder, H. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00230.2005 · Cited by 8

Authors: Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K.
Affiliations: University of Pittsburgh Medical Center (US)
Corresponding author: Ryter, Stefan W.
ORCID: Ryter, Stefan W.
Otterbein, Leo E.
Choi, Augustine M.K.
Venue: Molecular and Cellular Biochemistry
Publisher: Springer Science and Business Media LLC
Published: 2002-05
Volume: 234-235
Issue: 1
Pages: 249-263
ISSN: 0300-8177 (ISSN-L)
1573-4919
DOI: 10.1023/a:1015957026924
PMC: PMC7101540
OpenAlex: W2171750543
Cited by: 497
References: 209
Citations by year: 2026: 5 · 2025: 4 · 2024: 7 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 21 · 2019: 6 · 2018: 14 · 2017: 25 · 2016: 19 · 2015: 19 · 2014: 29 · 2013: 28 · 2012: 26
FWCI: 8.34
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Molecular and Cellular Biochemistry (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: carbon monoxide, heme oxygenase, heme oxygenase-1, heme oxygenase-2, oxidative stress, biliverdin, bilirubin, guanylate cyclase, cyclic GMP, cytoprotection, anti-inflammatory activity, anti-apoptotic effects, p38 MAPK signaling, oxidative lung injury, vascular tone, platelet aggregation, neurotransmitters
MeSH terms: Animals, Anti-Inflammatory Agents, Carbon Monoxide, Heme Oxygenase (Decyclizing), Humans, Inflammation, Isoenzymes, Stress, Physiological, Signal Transduction, Gene Expression Regulation, Enzymologic, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks