Cited by 269Health Systems, Economic Evaluations, Quality of LifeHIV/AIDS Research and InterventionsHealth Education and Validation

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Applications of the Medical Outcomes Study health-related quality of life measures in HIV/AIDS

Wu, A. W., Hays, R. D., Kelly, S., Malitz, F., Bozzette, S. A.·1997·Quality of Life Research

DOI 10.1023/a:1018460132567

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Abstract

The leading health status instruments in human immunodeficiency virus (HIV) research are based on the pool of items developed as part of the Medical Outcomes Study (MOS). The measures include the SF-20, MOS-HIV, SF-36, SF-12, SF-56, SF-38 (Patient Reported Status and Experience Survey (PARSE)), SF-21 and HIV Cost and Service Utilization Study (HCSUS) questionnaires. The instrument length ranges from 12 to 56 items, covering two to 11 dimensions. Completion requires from 2 to 14 minutes. Subscales are scored on a 0-100 scale (a higher score indicates better health); physical and mental health or overall summary scores are available for most of the measures. Three of the instruments are available in multiple languages. The instruments have been administered to over 20,000 persons with HIV in descriptive studies and clinical trials and there is substantial evidence for their reliability, construct and predictive validity and responsiveness. In several studies the measures have shown important differences between treatments. Although existing measures do not assess all domains relevant to HIV disease, additional subscales are available from the MOS pool. Some of the subscales may be prone to floor and ceiling effects. However, summary scales that encompass all of the subscales reduce this issue. Selection among MOS measures should be dictated by specific questions, the balance of available time and resources, and practical concerns.

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Authors: Wu, A. W., Hays, R. D., Kelly, S., Malitz, F., & Bozzette, S. A.
Affiliations: Johns Hopkins University (US)
University of California, Los Angeles (US)
Social and Scientific Systems (United States) (US)
RAND Corporation (US)
ORCID: Wu, A. W.
Hays, R. D.
Venue: Quality of Life Research
Publisher: Springer Science and Business Media LLC
Published: 1997-11
Volume: 6
Issue: 6
Pages: 531-554
ISSN: 0962-9343 (ISSN-L)
1573-2649
DOI: 10.1023/a:1018460132567
OpenAlex: W1597395255
Cited by: 269
References: 82
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 11 · 2020: 4 · 2019: 5 · 2018: 14 · 2017: 6 · 2016: 10 · 2015: 8 · 2014: 2 · 2013: 15 · 2012: 13
FWCI: 35.38
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Quality of Life Research (publishedVersion)
PubMed (publishedVersion)
Funders: Agency for Healthcare Research and Quality (HS07824)
National Eye Institute (U10EY008052, U10 EY 0850, U10-EY08052)
Topics: Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Health Sciences › Nursing › Research and Theory › Health Education and Validation
Keywords: HIV/AIDS, health-related quality of life, Medical Outcomes Study, SF-36, SF-20, MOS-HIV, Parse, health status questionnaires, instrument selection, floor and ceiling effects
MeSH terms: Female, Health Surveys, Humans, Male, Psychometrics, Quality of Life, Reproducibility of Results, HIV Infections, Outcome Assessment, Health Care

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Applications of the Medical Outcomes Study health-related quality of life measures in HIV/AIDS

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