Cited by 124Estrogen and related hormone effectsBreast Cancer Treatment StudiesProstate Cancer Treatment and Research

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Role of the androgen receptor in human breast cancer.

Birrell, S. N., Hall, R. E., Tilley, W. D.·1998·Journal of Mammary Gland Biology and Neoplasia

DOI 10.1023/a:1018730519839

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Abstract

Although the androgen receptor (AR)3 is often co-expressed with the estrogen receptor (ER) and progesterone receptor (PR) in human breast tumors, its role in breast cancer is poorly understood. Specific growth stimulatory and inhibitory actions of androgens have been described in human breast cancer cell lines. The mechanisms by which androgens exert these contrasting growth effects are unknown. A commonly utilized second line therapy for the treatment of advanced breast cancer is high dose medroxyprogesterone acetate (MPA). Although MPA, a synthetic progestin, was thought to act exclusively through the PR, the androgenic side-effects observed in women taking MPA suggest that its action may also be mediated in part by the AR. In support of this hypothesis, the level of AR measured by radioligand binding in primary breast tumors was correlated with the duration of response to MPA treatment following failure of tamoxifen therapy. Recent data suggest that the presence of structurally altered AR in breast cancers may account for unresponsiveness to MPA in some of these cases. Further studies are warranted to determine the role of AR mediated pathways in regulating breast tumor growth. In particular, identification of androgen-regulated genes may lead to new possibilities for the hormonal treatment of breast cancer.

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Authors: Birrell, S. N., Hall, R. E., & Tilley, W. D.
Affiliations: Flinders University (AU)
ORCID: Birrell, S. N.
Tilley, W. D.
Venue: Journal of Mammary Gland Biology and Neoplasia
Publisher: Springer Science and Business Media LLC
Published: 1998-01
Volume: 3
Issue: 1
Pages: 95-103
ISSN: 1083-3021 (ISSN-L)
1573-7039
DOI: 10.1023/a:1018730519839
OpenAlex: W1578641183
Cited by: 124
References: 50
Citations by year: 2024: 3 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 6 · 2012: 7
FWCI: 1.71
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Journal of Mammary Gland Biology and Neoplasia (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Keywords: androgen receptor, breast cancer, medroxyprogesterone acetate, progestin resistance, tamoxifen resistance, androgen-regulated genes, hormone therapy, androgen receptor mutations, tumor growth control, estrogen receptor, progesterone receptor
MeSH terms: Breast Neoplasms, Female, Humans, Receptors, Androgen

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Role of the androgen receptor in human breast cancer.

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