The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Role of the androgen receptor in human breast cancer.
Abstract
Although the androgen receptor (AR)3 is often co-expressed with the estrogen receptor (ER) and progesterone receptor (PR) in human breast tumors, its role in breast cancer is poorly understood. Specific growth stimulatory and inhibitory actions of androgens have been described in human breast cancer cell lines. The mechanisms by which androgens exert these contrasting growth effects are unknown. A commonly utilized second line therapy for the treatment of advanced breast cancer is high dose medroxyprogesterone acetate (MPA). Although MPA, a synthetic progestin, was thought to act exclusively through the PR, the androgenic side-effects observed in women taking MPA suggest that its action may also be mediated in part by the AR. In support of this hypothesis, the level of AR measured by radioligand binding in primary breast tumors was correlated with the duration of response to MPA treatment following failure of tamoxifen therapy. Recent data suggest that the presence of structurally altered AR in breast cancers may account for unresponsiveness to MPA in some of these cases. Further studies are warranted to determine the role of AR mediated pathways in regulating breast tumor growth. In particular, identification of androgen-regulated genes may lead to new possibilities for the hormonal treatment of breast cancer.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“thus suggesting the role of AR in the beneficial effects of MPA in breast cancer in women (246, 247).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [246]
Citations
Cites
Androgen Receptor Defects: Historical, Clinical, and Molecular Perspectives*
Quigley, C. A., Bellis, A. D., Marschke, K. B., Awady, M. K. E., Wilson, E. M., & French, F. S. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-271 · Cited by 1,459
Cloning of Human Androgen Receptor Complementary DNA and Localization to the X Chromosome
Lubahn, D. B., JOSEPH, D. R., Sullivan, P. M., Willard, H. F., French, F. S., & Wilson, E. M. (1988) · Science · doi:10.1126/science.3353727 · Cited by 1,003
Čulig, Z., Hobisch, A., Cronauer, M. V., Radmayr, C., Trapman, J., Hittmair, A., Bartsch, G., & Klocker, H. (1994) · PubMed · Cited by 938
Molecular Cloning of Human and Rat Complementary DNA Encoding Androgen Receptors
Chang, C. S., Kokontis, J. M., & Liao, S. (1988) · Science · doi:10.1126/science.3353726 · Cited by 891
Progestin regulation of cellular proliferation.
CLARKE, C. L., & SUTHERLAND, R. L. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-2-266 · Cited by 650
Characterization and expression of a cDNA encoding the human androgen receptor.
Tilley, W. D., Marcelli, M., Wilson, J. D., & McPhaul, M. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.1.327 · Cited by 476
Self-citationActivation of the human androgen receptor through a protein kinase A signaling pathway.
Nazareth, L. V., & Weigel, N. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.19900 · Cited by 429
Endocrine treatment of breast cancer in women
SANTEN, R. J., MANNI, A., HARVEY, H., & REDMOND, C. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-2-221 · Cited by 399
Johnston, S. R. D., Saccani‐Jotti, G., Smith, I. E., Salter, J., Newby, J. C., Coppen, M. J., Ebbs, S. R., & Dowsett, M. (1995) · PubMed · Cited by 301
Steroid receptor analyses of nine human breast cancer cell lines.
Horwitz, K. B., Zava, D. T., Thilagar, A. K., Jensen, E. M., & McGuire, W. L. (1978) · PubMed · Cited by 300
Research works printed but not linked: 1
- S. N. Birrell, J. M. Bentel, D. J. Horsfall, and W. D. Tilley (1996). Androgen receptor expression and medroxyprogeste r-one acetate therapy in human breast cancer. Proc. Amer. Assoc. Cancer Res. 37:237.
Cited by
Sorted by citations
Identification of molecular apocrine breast tumours by microarray analysis
Farmer, P. J., Bonnefoi, H. R., Becette, V., Tubiana-Hulin, M., Fumoleau, P., Larsimont, D., MacGrogan, G. M., Bergh, J. C. S., Cameron, D., Goldstein, D., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208561 · Cited by 822
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544
Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1
Robinson, J. L. L., MacArthur, S., Ross-Innes, C. S., Tilley, W. D., Neal, D. E., Mills, I. G., & Carroll, J. S. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.216 · Cited by 300
Self-citationChmelar, R. S., Buchanan, G., Need, E. F., Tilley, W. D., & Greenberg, N. M. (2006) · International Journal of Cancer · doi:10.1002/ijc.22365 · Cited by 260
Self-citationModification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat.
Rebbeck, T. R., Kantoff, P. W., Krithivas, K., Neuhausen, S., Blackwood, M. A., Godwin, A. K., Daly, M. B., Narod, S. A., Garber, J. E., Lynch, H. T., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302366 · Cited by 252
Metadata
- Authors
- Birrell, S. N., Hall, R. E., & Tilley, W. D.
- Affiliations
- Flinders University (AU)
- Venue
- Journal of Mammary Gland Biology and Neoplasia
- Published
- 1998-01
- Volume
- 3
- Issue
- 1
- Pages
- 95-103
- ISSN
- 1083-3021 (ISSN-L)
- 1573-7039
- OpenAlex
- W1578641183
- Cited by
- 124
- References
- 50
- Citations by year
- 2024: 3 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 6 · 2012: 7
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Mammary Gland Biology and Neoplasia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Keywords
- androgen receptor, breast cancer, medroxyprogesterone acetate, progestin resistance, tamoxifen resistance, androgen-regulated genes, hormone therapy, androgen receptor mutations, tumor growth control, estrogen receptor, progesterone receptor
- MeSH terms
- Breast Neoplasms, Female, Humans, Receptors, Androgen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
