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Chemical aspects of siderophore mediated iron transport
Abstract
In this mini-review we describe selected aspects of the coordination chemistry relevant to siderophore mediated iron transport and bioavailability. Specific emphasis is placed on a discussion of in vitro kinetic and thermodynamic data that are relevant to elucidating possible in vivo mechanisms for environmental iron acquisition by microbial cells.
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“Consequently, and because these reflect fundamental physicochemical properties of such ions, the problems of both solubility and toxicity were faced by bacteria (and indeed fungi [166-169]) long ago in evolution, and were solved by their creation and excretion of (mainly ferric-)iron chelators known as siderophores [170-189] (and for haemophores see [190]). These typically have extremely tight b”
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Metadata
- Authors
- Boukhalfa, H., & Crumbliss, A. L.
- Affiliations
- Duke University (US)
- Corresponding author
- Crumbliss, Alvin L.
- Venue
- Biometals
- Published
- 2002-12
- Volume
- 15
- Issue
- 4
- Pages
- 325-339
- ISSN
- 0966-0844 (ISSN-L)
- 1572-8773
- OpenAlex
- W1657518708
- Cited by
- 547
- References
- 74
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 21 · 2023: 27 · 2022: 22 · 2021: 24 · 2020: 32 · 2019: 27 · 2018: 25 · 2017: 34 · 2016: 26 · 2015: 28 · 2014: 32 · 2013: 18 · 2012: 27
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- BioMetals (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Physical Sciences › Chemistry › Inorganic Chemistry › Inorganic and Organometallic Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- siderophores, iron transport, iron acquisition, coordination chemistry, bioavailability, thermodynamics, kinetics, metal complexes
- MeSH terms
- Animals, Deferoxamine, Ferric Compounds, Humans, Hydrogen-Ion Concentration, Iron, Kinetics, Ligands, Oxidation-Reduction, Peptides, Cyclic, Solubility, Siderophores
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