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Chemical aspects of siderophore mediated iron transport
Abstract
In this mini-review we describe selected aspects of the coordination chemistry relevant to siderophore mediated iron transport and bioavailability. Specific emphasis is placed on a discussion of in vitro kinetic and thermodynamic data that are relevant to elucidating possible in vivo mechanisms for environmental iron acquisition by microbial cells.
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“Consequently, and because these reflect fundamental physicochemical properties of such ions, the problems of both solubility and toxicity were faced by bacteria (and indeed fungi [166-169]) long ago in evolution, and were solved by their creation and excretion of (mainly ferric-)iron chelators known as siderophores [170-189] (and for haemophores see [190]). These typically have extremely tight b”
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Metadata
- Authors
- Boukhalfa, H., & Crumbliss, A. L.
- Affiliations
- Duke University (US)
- Corresponding author
- Crumbliss, Alvin L.
- Venue
- Biometals
- Published
- 2002-12
- Volume
- 15
- Issue
- 4
- Pages
- 325-339
- ISSN
- 0966-0844 (ISSN-L)
- 1572-8773
- OpenAlex
- W1657518708
- Cited by
- 547
- References
- 74
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 21 · 2023: 27 · 2022: 22 · 2021: 24 · 2020: 32 · 2019: 27 · 2018: 25 · 2017: 34 · 2016: 26 · 2015: 28 · 2014: 32 · 2013: 18 · 2012: 27
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- BioMetals (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Physical Sciences › Chemistry › Inorganic Chemistry › Inorganic and Organometallic Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- siderophores, iron transport, iron acquisition, coordination chemistry, bioavailability, thermodynamics, kinetics, metal complexes
- MeSH terms
- Animals, Deferoxamine, Ferric Compounds, Humans, Hydrogen-Ion Concentration, Iron, Kinetics, Ligands, Oxidation-Reduction, Peptides, Cyclic, Solubility, Siderophores
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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