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Effect of Lactobacillus plantarum 299v on Colonic Fermentation and Symptoms of Irritable Bowel Syndrome
Abstract
A number of recent clinical trials have promoted the use of probiotic bacteria as a treatment for irritable bowel syndrome (IBS). The recent demonstration of abnormal colonic fermentation in some patients with this condition provides an opportunity for the objective assessment of the therapeutic value of these bacteria. This study was designed to investigate the effects of Lactobacillus plantarum 299V on colonic fermentation. We conducted a double-blind, placebo-controlled, cross-over, four-week trial of Lactobacillus plantarum 299V in 12 previously untreated patients with IBS. Symptoms were assessed daily by a validated composite score and fermentation by 24-hr indirect calorimetry in a 1.4-m3 canopy followed by breath hydrogen determination for 3 hr after 20 ml of lactulose. On placebo, the median symptom score was 8.5 [6.25-11.25 interquartile range (IQR)], the median maximum rate of gas production was 0.55 ml/min (0.4-1.1 IQR), and the median hydrogen production was 189.7 ml/24 hr (118.3-291.1 IQR). On Lactobacillus plantarum 299V the median symptom score was 8 (6.75-13.5 IQR), the median maximum rate of gas production 0.92 ml/min (0.45-1.5 IQR), and the median hydrogen production 208.2 ml/24 hr (146-350.9 IQR). There was no significant difference. Breath hydrogen excretion after lactulose was reduced by the probiotic (median at 120 min, 6 ppm; placebo, 17 ppm; P = 0.019). In conclusion, Lactobacillus plantarum 299V in this study did not appear to alter colonic fermentati…
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In the citing paper
“Two studies reported no difference between specific probiotic treatments and placebo,28–37 and one study reported a significant worsening of diarrhoea with the specific probiotic treatment compared with placebo.59”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [30]
In the citing paper
“Twelve studies evaluated abdominal pain as a secondary end point only. Results from these studies were mixed: one reported a negative effect of the specific probiotic treatment,59 eight (examining six different probiotics) reported no significant effect28–38 and three reported a significant beneficial effect of three different probiotics35,39”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [30]
In the citing paper
“all three studies that examined flatus as a primary end point,30,57 and four of seven studies in which flatus was a secondary end point only,28–38 showed no significant difference between seven specific probiotic treatments and control.”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [30]
In the citing paper
“Probiotics tested to date do not help reduce flatus in patients with IBS Low [147,149-150,156,168,174-175, 178-179,184]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [178]
Citations
Cites
Predicting basal metabolic rate, new standards and review of previous work.
Wn, S. (1985) · PubMed · Cited by 2,911
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., & Campieri, M. (2000) · Gastroenterology · doi:10.1053/gast.2000.9370 · Cited by 1,485
A double‐blind, placebo‐controlled trial
Pinals, R. S., Kaplan, S. B., Lawson, J. G., & Hepburn, B. (1986) · Arthritis & Rheumatism · doi:10.1002/art.1780291202 · Cited by 1,355
Nobaek, S., Johansson, M.-L., Molin, G., Ahrné, S., & Jeppsson, B. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02015.x · Cited by 653
Guarner, F. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(97)00136-0 · Cited by 638
Alander, M., Satokari, R. M., Korpela, R., Saxelin, M., Vilpponen-Salmela, T., Mattila, T., & von Wright, A. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.1.351-354.1999 · Cited by 526
Abnormal colonic fermentation in irritable bowel syndrome
King, T. S., Elia, M., & Hunter, J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02146-1 · Cited by 473
Self-citationIncreased risk of irritable bowel syndrome after bacterial gastroenteritis: cohort study
Rodríguez, L. A. G., & Ruigómez, A. (1999) · British medical journal · doi:10.1136/bmj.318.7183.565 · Cited by 409
Controlled treatment trials in the irritable bowel syndrome: A critique
Klein, K. B. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90319-8 · Cited by 381
FOOD INTOLERANCE: A MAJOR FACTOR IN THE PATHOGENESIS OF IRRITABLE BOWEL SYNDROME
Jones, V. A., Shorthouse, M., McLaughlan, P., Workman, E., & Hunter, J. O. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92782-9 · Cited by 333
Self-citationMalin, M., Suomalainen, H., Saxelin, M., & Isolauri, E. (1996) · Annals of Nutrition and Metabolism · doi:10.1159/000177907 · Cited by 316
Food intolerance and the irritable bowel syndrome.
Nanda, R., James, R., Smith, H., Dudley, C. R., & Jewell, D. P. (1989) · Gut · doi:10.1136/gut.30.8.1099 · Cited by 307
Irritable bowel syndrome in office-based practice in the United States
Everhart, J. E., & Renault, P. F. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90275-p · Cited by 304
The effects of Lactobacillus strains and oat fiber on methotrexate- induced enterocolitis in rats
Mao, Y., Nobaek, S., Kasravi, F. B., Adawi, D., Stenram, U., Molin, G., & Jeppsson, B. W. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8690198 · Cited by 296
(1982) · PubMed · Cited by 251
Johansson, M.-L., Nobaek, S., Berggren, A., Nyman, M., Björck, I., Ahrné, S., Jeppsson, B., & Molin, G. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00055-5 · Cited by 187
Probiotics, prebiotics or `conbiotics'?
Berg, R. D. (1998) · Trends in Microbiology · doi:10.1016/s0966-842x(98)01224-4 · Cited by 137
Maxwell, P., Mendall, M., & Kumar, D. (1997) · The Lancet · doi:10.1016/s0140-6736(97)05276-8 · Cited by 121
Bengmark, S. (1996) · Clinical Nutrition · doi:10.1016/s0261-5614(96)80253-6 · Cited by 99
Parker, T. J., Naylor, S. J., Riordan, A. M., & Hunter, J. O. (1995) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.1995.tb00308.x · Cited by 72
Self-citationInstability in the faecal flora of a patient suffering from food-related irritable bowel syndrome
BRADLEY, H. K., Wyatt, G. M., Bayliss, C. E., & HUNTER, J. O. (1987) · Journal of Medical Microbiology · doi:10.1099/00222615-23-1-29 · Cited by 65
Self-citationPlacebo responsiveness--influence of previous therapy.
Batterman, R. C., & Lower, W. R. (1968) · PubMed · Cited by 37
The Aetiological Role of Antibiotic Prophylaxis with Hysterectomy in Irritable Bowel Syndrome
Alun-Jones, V., Wilson, A., Hunter, J. O., & Robinson, R. E. (1984) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443618409075757 · Cited by 31
Self-citationRecent Advances in Anaerobic Bacteriology
Willis, A. T. (1987) · Journal of Clinical Pathology · doi:10.1136/jcp.40.8.934-e · Cited by 3
Research works printed but not linked: 3
- Bayliss CE, Houston AP, Alun-Jones V, et al: Microbiological studies on food intolerance. Proc Nutr Soc 43:16A, 1984
- King TS, Hunter JO: Do symptoms improve with quality of life in IBS? Gut 40(suppl 1):64, 1997(abstract)
- Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA: Functional bowel disease and functional abdominal pain. Gut 45(suppl II):1143–1147, 1999
Cited by
Sorted by citations
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
Probiotics, Prebiotics, and Synbiotics
de Vrese, M., & Schrezenmeir, J. (2008) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2008_097 · Cited by 1,061
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939
Potential Uses of Probiotics in Clinical Practice
Reid, G., Jaß, J., Sebulsky, M. T., & McCormick, J. K. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.4.658-672.2003 · Cited by 918
Rezaie, A. R., Buresi, M. C., Lembo, A. J., Lin, H. C., McCallum, R. W., Rao, S. S. C., Schmulson, M. J., Valdovinos, M. A., Zakko, S. F., & Pimentel, M. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.46 · Cited by 850
Metadata
- Authors
- Sen, S., Mullan, M. M., Parker, T. J., Woolner, J. T., Tarry, S. A., & Hunter, J. O.
- Affiliations
- Addenbrooke's Hospital (GB)
- ORCID
- Parker, T.J.
- Venue
- Digestive Diseases and Sciences
- Published
- 2002-11
- Volume
- 47
- Issue
- 11
- Pages
- 2615-2620
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2059455849
- Cited by
- 245
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 2 · 2014: 16 · 2013: 12 · 2012: 17
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lunds Universitet
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus plantarum 299v, irritable bowel syndrome, probiotics, colonic fermentation, breath hydrogen, lactulose breath test, gas production, IBS symptoms, indirect calorimetry
- MeSH terms
- Adult, Breath Tests, Calorimetry, Indirect, Colon, Colonic Diseases, Functional, Double-Blind Method, Female, Fermentation, Humans, Hydrogen, Lactobacillus, Male, Middle Aged, Avena, Cross-Over Studies, Probiotics
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