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Plasma Amino Acid Levels in Children with Autism and Their Families
Abstract
Plasma amino acid levels were measured in autistic and Asperger syndrome patients, their siblings, and parents. The results were compared with values from age-matched controls. Patients with autism or Asperger syndrome and their siblings and parents all had raised glutamic acid, phenylalanine, asparagine, tyrosine, alanine, and lysine (p < .05) than controls, with reduced plasma glutamine. Other amino acids were at normal levels. These results show that children with autistic spectrum disorders come from a family background of dysregulated amino acid metabolism and provide further evidence for an underlying biochemical basis for the condition.
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“amino-acid transport and degradation differ between TD and ASD individuals (Aldred et al., 2003; Evans et al., 2008)”
From Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019) · cites this paper as Aldred et al., 2003
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Metadata
- Authors
- Aldred, S., Moore, K. M., Fitzgerald, M., & Waring, R. H.
- Affiliations
- Aston University (GB)
- University of Birmingham (GB)
- Corresponding author
- Waring, Rosemary H.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2003-02
- Volume
- 33
- Issue
- 1
- Pages
- 93-97
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W1506956777
- Cited by
- 188
- References
- 18
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 11 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 12 · 2014: 13 · 2013: 7 · 2012: 11
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, Asperger syndrome, plasma amino acids, amino acid metabolism, glutamate, phenylalanine, asparagine, tyrosine, alanine, lysine, glutamine, siblings, parents
- MeSH terms
- Adolescent, Alanine, Amino Acids, Asparagine, Autistic Disorder, Child, Child, Preschool, Family, Female, Glutamine, Humans, Lysine, Male, Phenylalanine, Tyrosine, Glutamic Acid, Brain Diseases, Metabolic, Inborn, Asperger Syndrome
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