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Effect of Hypo- and Hyperthyroidism on Gastric Myoelectrical Activity
Abstract
Although hypo- and hyperthyroid patients have different symptoms in the gastrointestinal tract, the mechanism of thyroid action on the gut remains poorly understood. Thus the aim of this study was to investigate the effect of hypo- and hyperthyroidism on gastric myoelectrical activity, gastric emptying, dyspeptic symptoms. Twenty-two hyperthyroid (median age 45, 15 females) and 11 hypothyroid (median age 42, 10 females) patients were included into the study. Dyspepsia score, hypo- and hyperthyroid symptom scale, abdominal ultrasonography and upper gastrointestinal endoscopy were performed. Gastric myoelectrical activity was measured by electrogastrograpy (EGG) before and after therapy both preprandially and postprandially and compared with age, gender, and body-matched controls (12 for hypothyroid, 15 for hyperthyroid patients). Radionuclide gastric emptying studies were performed with a solid meal. Hypothyroid patients revealed a significant increase in preprandial tachygastria as compared with controls (12.3% vs 4.8%). The percentage of preprandial normal slow waves (2.4-3.7 cpm) was below 70% (dysmotility) in 7 of 11 hypothyroid patients versus 2 of 12 controls (P < 0.05). Hyperthyroid patients revealed a significantly higher preprandial (3.1 vs 2.8) and postprandial (3.4 vs 3) DF when compared with the controls (P < 0.05). A higher percentage of postprandial taschygastria (7.9 vs 0) was present in hyperthyroid patients than in the controls (P < 0.05). The decrease on post…
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“In hyperthyroidism individuals, gastric emptying can be delayed, rapid or normal (Gunsar et al., 2003; Kisakol et al., 2003).”
From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Gunsar et al., 2003
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Metadata
- Authors
- Gunsar, F., Yilmaz, S., Bor, S., Kumanlioglu, K., Çetinkalp, S., Kabalak, T., & Ozutemiz, O. A.
- Affiliations
- Ege University (TR)
- ORCID
- Bor, Serhat
- Venue
- Digestive Diseases and Sciences
- Published
- 2003-04
- Volume
- 48
- Issue
- 4
- Pages
- 706-712
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W1505347092
- Cited by
- 37
- References
- 23
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- hypothyroidism, hyperthyroidism, gastric myoelectrical activity, electrogastrography, gastric slow waves, tachygastria, gastric emptying, dyspepsia, gastrointestinal motility disorders, thyroid hormone replacement, postprandial gastric activity, power ratio, upper gastrointestinal endoscopy, abdominal ultrasound
- MeSH terms
- Adolescent, Adult, Aged, Dyspepsia, Electrodiagnosis, Female, Fourier Analysis, Gastric Emptying, Humans, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Signal Processing, Computer-Assisted, Stomach, Thyroxine, Triiodothyronine, Myoelectric Complex, Migrating
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