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Cited by 102Thyroid Disorders and TreatmentsCeliac Disease Research and ManagementGastrointestinal motility and disorders

Consequences of dysthyroidism on the digestive tract and viscera

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Daher, Ronald, Yazbeck, Thierry, Jaoude, Joe Bou, Abboud, Bassam·2009·World Journal of Gastroenterology
DOI 10.3748/wjg.15.2834PMC PMC2699000
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Abstract

Thyroid hormones define basal metabolism throughout the body, particularly in the intestine and viscera. Gastrointestinal manifestations of dysthyroidism are numerous and involve all portions of the tract. Thyroid hormone action on motility has been widely studied, but more complex pathophysiologic mechanisms have been indicated by some studies although these are not fully understood. Both thyroid hormone excess and deficiency can have similar digestive manifestations, such as diarrhea, although the mechanism is different in each situation. The liver is the most affected organ in both hypo- and hyperthyroidism. Specific digestive diseases may be associated with autoimmune thyroid processes, such as Hashimoto's thyroiditis and Grave's disease. Among them, celiac sprue and primary biliary cirrhosis are the most frequent although a clear common mechanism has never been proven. Overall, thyroid-related digestive manifestations were described decades ago but studies are still needed in order to confirm old concepts or elucidate undiscovered mechanisms. All practitioners must be aware of digestive symptoms due to dysthyroidism in order to avoid misdiagnosis of rare but potentially lethal situations.

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Cited by

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Authors
Daher, R., Yazbeck, T., Jaoude, J. B., & Abboud, B.
Affiliations
University of Southern California (US)
Corresponding author
Abboud, Bassam
ORCID
Abboud, Bassam
Venue
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Inc.
Published
2009
Volume
15
Issue
23
Pages
2834
ISSN
1007-9327 (ISSN-L)
DOI
10.3748/wjg.15.2834
PMC
PMC2699000
OpenAlex
W2039483103
Cited by
102
References
0
Citations by year
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FWCI
0.61
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
thyroid dysfunction, hyperthyroidism, hypothyroidism, gastrointestinal manifestations, intestinal motility, diarrhea, liver involvement, Hashimoto's thyroiditis, Graves' disease, celiac disease, primary biliary cirrhosis, autoimmune thyroid disease, thyroid hormones
MeSH terms
Gastrointestinal Diseases, Humans, Hyperthyroidism, Hypothyroidism, Thyroid Hormones, Gastrointestinal Tract

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