β-Catenin and Tcfs in Mammary Development and Cancer

Identification of c- <i>MYC</i> as a Target of the APC Pathway

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β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601 · see citing works

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

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The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

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The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

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β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352 · see citing works

Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion

Vasioukhin, V., Bauer, C., Yin, M., & Fuchs, E. (2000) · Cell · doi:10.1016/s0092-8674(00)81559-7 · Cited by 1,205 · see citing works

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089 · see citing works

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.Preprint

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Cyclin D1 provides a link between development and oncogenesis in the retina and breast

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Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

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Exogenous Expression of N-Cadherin in Breast Cancer Cells Induces Cell Migration, Invasion, and Metastasis

Hazan, R. B., Phillips, G. R., Qiao, R., Norton, L., & Aaronson, S. A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.4.779 · Cited by 934 · see citing works

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

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β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

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Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

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E‐cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

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Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

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Drosophila Tcf and Groucho interact to repress Wingless signalling activity

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Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

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Three-Dimensional Structure of the Armadillo Repeat Region of β-Catenin

Huber, A. H., Nelson, W. J., & Weis, W. I. (1997) · Cell · doi:10.1016/s0092-8674(00)80352-9 · Cited by 706 · see citing works

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

Fantl, V, Stamp, G., Andrews, A., Rosewell, I., & Dickson, C. (1995) · Genes &amp; Development · doi:10.1101/gad.9.19.2364 · Cited by 691 · see citing works

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.

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The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature · doi:10.1038/21674 · Cited by 624 · see citing works

Regulation of E-cadherin/Catenin Association by Tyrosine Phosphorylation

Roura, S., Miravet, S., Piedra, J. A., de Herreros, A. G., & Duñach, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36734 · Cited by 603 · see citing works

Siah-1, SIP, and Ebi Collaborate in a Novel Pathway for β-Catenin Degradation Linked to p53 Responses

Matsuzawa, S.-I., & Reed, J. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00242-8 · Cited by 587 · see citing works

New aspects of Wnt signaling pathways in higher vertebrates

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A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor

Suyama, K., Shapiro, I. M., Guttman, M., & Hazan, R. B. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00150-2 · Cited by 515 · see citing works

Role of IQGAP1, a Target of the Small GTPases Cdc42 and Rac1, in Regulation of E-Cadherin- Mediated Cell-Cell Adhesion

Kuroda, S., Fukata, M., Nakagawa, M., Fujii, K., Nakamura, T., Ookubo, T., Izawa, I., Nagase, T., Nomura, N., Tani, H., et al. (1998) · Science · doi:10.1126/science.281.5378.832 · Cited by 499 · see citing works

Essential function of Wnt-4 in mammary gland development downstream of progesterone signalingPreprint

Brisken, C., Heineman, A., Chavarria, T. E., Elenbaas, B., Tan, J., Dey, S. K., McMahon, J. A., McMahon, A. P., & Weinberg, R. A. (2000) · Genes & Development · doi:10.1101/gad.14.6.650 · Cited by 490 · see citing works

A paracrine role for the epithelial progesterone receptor in mammary gland development

Brisken, C., Park, S. H., Vass, T., Lydon, J. P., O’Malley, B. W., & Weinberg, R. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5076 · Cited by 479 · see citing works

Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1

Roose, J. P., Huls, G. A., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., & Clevers, H. C. (1999) · Science · doi:10.1126/science.285.5435.1923 · Cited by 456 · see citing works

Siah-1 Mediates a Novel β-Catenin Degradation Pathway Linking p53 to the Adenomatous Polyposis Coli Protein

Liu, J., Stevens, J., Rote, C. A., Yost, H. J., Hu, Y., Neufeld, K. L., White, R. L., & Matsunami, N. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00241-6 · Cited by 422 · see citing works

β-catenin interacts with and inhibits NF-κB in human colon and breast cancer

Deng, J., Miller, S. A., Wang, H.-Y., Xia, W., Wen, Y., Zhou, B. P., Li, Y., Lin, S., & Hung, M. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00154-x · Cited by 372 · see citing works

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

Waltzer, L., & Bienz, M. (1998) · Nature · doi:10.1038/26785 · Cited by 360 · see citing works

Akt Participation in the Wnt Signaling Pathway through Dishevelled

Fukumoto, S., Hsieh, C.-M., Maemura, K., Layne, M. D., Yet, S., Lee, K.-H., Matsui, T., Rosenzweig, A., Taylor, W. G., Rubin, J. S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000880200 · Cited by 335 · see citing works

Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion

Yamamoto, M., Bharti, A. K., Li, Y., & Kufe, D. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12492 · Cited by 308 · see citing works

ApcMin: A mouse model for intestinal and mammary tumorigenesis

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Coupling Assembly of the E-Cadherin/β-Catenin Complex to Efficient Endoplasmic Reticulum Exit and Basal-lateral Membrane Targeting of E-Cadherin in Polarized MDCK Cells

Chen, Y., Stewart, D. B., & Nelson, W. J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.4.687 · Cited by 303 · see citing works

Precocious Mammary Gland Development in P-Cadherin–deficient Mice

Radice, G., Ferreira-Cornwell, M., Robinson, S., Rayburn, H., Chodosh, L., Takeichi, M., & Hynes, R. (1997) · Journal of Cell Biology · doi:10.1083/jcb.139.4.1025 · Cited by 286 · see citing works

TCF transcription factors: molecular switches in carcinogenesis

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WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans

Rocheleau, C. E., Yasuda, J., Shin, T. H., Lin, R., Sawa, H., Okano, H., Priess, J. R., Davis, R. J., & Mello, C. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80784-9 · Cited by 276 · see citing works

Tumor Suppressor Pten Inhibits Nuclear Accumulation of β-Catenin and T Cell/Lymphoid Enhancer Factor 1–Mediated Transcriptional Activation

Persad, S., Troussard, A. A., McPhee, T. R., Mulholland, D. J., & Dedhar, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.6.1161 · Cited by 268 · see citing works

Cyclins and Breast Cancer

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E-cadherin is a survival factor for the lactating mouse mammary gland

Boussadia, O., Kutsch, S., Hierholzer, A., Delmas, V., & Kemler, R. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00090-4 · Cited by 248 · see citing works

Aberrant methylation of the adenomatous polyposis coli (APC) gene promoter 1A in breast and lung carcinomas.

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Interaction of Glycogen Synthase Kinase 3β with the DF3/MUC1 Carcinoma-Associated Antigen and β-Catenin

Li, Y., Bharti, A. K., Chen, D., Gong, J., & Kufe, D. W. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7216 · Cited by 241 · see citing works

Cell signaling through membrane mucins

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Presenilin Couples the Paired Phosphorylation of β-Catenin Independent of Axin

Kang, D. E., Soriano, S., Xia, X., Eberhart, C. G., Strooper, B. D., Zheng, H., & Koo, E. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00970-4 · Cited by 232 · see citing works

The c-Src Tyrosine Kinase Regulates Signaling of the Human DF3/MUC1 Carcinoma-associated Antigen with GSK3β and β-Catenin

Li, Y., Kuwahara, H., Ren, J., Wen, G., & Kufe, D. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000754200 · Cited by 227 · see citing works

Adhesion signaling: How β-catenin interacts with its partners

Gottardi, C. J., & Gumbiner, B. M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00473-0 · Cited by 227 · see citing works

Down-Regulation of β-Catenin by Activated p53

Sadot, E., Geiger, B., Oren, M., & Ben‐Ze'ev, A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.6768-6781.2001 · Cited by 225 · see citing works

Fundic Gland Polyps in Familial Adenomatous Polyposis

Abraham, S. C., Nobukawa, B., Giardiello, F. M., Hamilton, S. R., & Wu, T. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64588-9 · Cited by 220 · see citing works

Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas.

Jönsson, M., Dejmek, J. S., Bendahl, P., & Andersson, T. (2002) · PubMed · Cited by 212 · see citing works

Regulation of Lymphoid Enhancer Factor 1/T-Cell Factor by Mitogen-Activated Protein Kinase-Related Nemo-Like Kinase-Dependent Phosphorylation in Wnt/β-Catenin Signaling

Ishitani, T., Ninomiya-Tsuji, J., & Matsumoto, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1379-1389.2003 · Cited by 212 · cited 2× · see citing works

Casein Kinase II Phosphorylation of E-cadherin Increases E-cadherin/β-Catenin Interaction and Strengthens Cell-Cell Adhesion

Lickert, H., Bauer, A., Kemler, R., & Stappert, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.5090 · Cited by 200 · see citing works

Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.

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Δn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland

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Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.

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Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein

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Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development

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WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type

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Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells.

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β-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland

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c-erbB-2 Gene Product Directly Associates with β-Catenin and Plakoglobin

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Sequence variants of the axin gene in breast, colon, and other cancers: An analysis of mutations that interfere with GSK3 binding

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Wnt5a cloning, expression, and up-regulation in human primary breast cancers.

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Developmental and hormonal regulation of Wnt gene expression in the mouse mammary gland

Weber-Hall, S. J., Phippard, D., Niemeyer, C. C., & Dale, T. C. (1994) · Differentiation · doi:10.1046/j.1432-0436.1994.5730205.x · Cited by 152 · see citing works

Expression of frizzled‐related protein and Wnt‐signalling molecules in invasive human breast tumours

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Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice

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Regulation of β-Catenin Function by the IκB Kinases

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Developmental and Hormonal Regulation of Wnt Gene Expression in the Mouse Mammary Gland

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Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice

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Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias

Miyoshi, K., Shillingford, J. M., Provost, F. L., Gounari, F., Bronson, R. T., von Boehmer, H., Taketo, M. M., Cardiff, R. D., Hennighausen, L. G., & Khazaie, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012414099 · Cited by 132 · see citing works

Fibroblast Growth Factor-2 Induces Lef/Tcf-dependent Transcription in Human Endothelial Cells

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Somatic Mutations of the APC Gene in Primary Breast Cancers

Furuuchi, K., Tada, M., Yamada, H., Kataoka, A., Furuuchi, N., Hamada, J., Takahashi, M., Todo, S., & Moriuchi, T. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65072-9 · Cited by 118 · see citing works

The Wnt pathway, epithelial–stromal interactions, and malignant progression in phyllodes tumours

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Activation of different Wnt/β-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors

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A β-catenin survival signal is required for normal lobular development in the mammary gland

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Muc4/Sialomucin Complex in the Mammary Gland and Breast Cancer

Carraway, K. L., III, Price‐Schiavi, S. A., Komatsu, M., Jepson, S., Perez, A., & Carraway, C. A. C. (2001) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1011327708973 · Cited by 90 · see citing works

Tiam1 Overexpression Potentiates Heregulin-induced Lymphoid Enhancer Factor-1/β-Catenin Nuclear Signaling in Breast Cancer Cells by Modulating the Intercellular Stability

Adam, L., Vadlamudi, R. K., McCrea, P. D., & Kumar, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009769200 · Cited by 87 · see citing works

Compartment switching of WNT-2 expression in human breast tumors.

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Impaired Mammary Gland Development in Cyl-1−/− Mice during Pregnancy and Lactation Is Epithelial Cell Autonomous

Fantl, V., Edwards, P. A., Steel, J. H., Vonderhaar, B. K., & Dickson, C. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9329 · Cited by 83 · see citing works

A developmental conundrum

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Localization and Quantification of Wnt-2 Gene Expression in Mouse Mammary Development

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ErbB-β-Catenin Complexes Are Associated with Human Infiltrating Ductal Breast and Murine Mammary Tumor Virus (MMTV)-Wnt-1 and MMTV-c-Neu Transgenic Carcinomas

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Atherosclerotic Calcification: Wnt Is the Hint

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MUC1-C Oncoprotein Induces TCF7L2 Transcription Factor Activation and Promotes Cyclin D1 Expression in Human Breast Cancer Cells

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SOX9 Regulates Low Density Lipoprotein Receptor-related Protein 6 (LRP6) and T-cell Factor 4 (TCF4) Expression and Wnt/β-catenin Activation in Breast Cancer

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Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast‐mediated stimulation of mineralization

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The Wnt Signaling Antagonist Kremen1 is Required for Development of Thymic Architecture

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BMP-6 promotes E-cadherin expression through repressing δEF1 in breast cancer cells

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Pygopus and the Wnt signaling pathway: A diverse set of connections

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Expression of periostin in the serum of NSCLC and its function on proliferation and migration of human lung adenocarcinoma cell line (A549) in vitro

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MMTV-Wnt1 and -ΔN89β-Catenin Induce Canonical Signaling in Distinct Progenitors and Differentially Activate Hedgehog Signaling within Mammary Tumors

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Characterization and Comparison of Intercellular Adherent Junctions Expressed by Human Corneal Endothelial Cells In Vivo and In Vitro

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The Molecular Basis of Wnt/β-Catenin Signaling Pathways in Neurodegenerative Diseases

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β-Catenin Is Not Necessary for Maintenance or Repair of the Bronchiolar Epithelium

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DNAJB6 Induces Degradation of β-Catenin and Causes Partial Reversal of Mesenchymal Phenotype

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Feedback Regulation between Zipcode Binding Protein 1 and β-Catenin mRNAs in Breast Cancer Cells

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Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/β-catenin signaling pathway

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Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1

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Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations

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Role of neural-cadherin in early osteoblastic differentiation of human bone marrow stromal cells cocultured with human umbilical vein endothelial cells

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A Tale of Two Signals: AR and WNT in Development and Tumorigenesis of Prostate and Mammary Gland

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