The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Demography, Clinical Characteristics, Psychological and Abuse Profiles, Treatment, and Long-Term Follow-up of Patients with Gastroparesis
Abstract
Patients with gastroparesis frequently present challenging clinical, diagnostic, and therapeutic problems. Data from 146 gastroparesis patients seen over six years were analyzed. Patients were evaluated at the time of initial diagnosis and at the most recent follow-up in terms of gastric emptying and gastrointestinal symptomatology. The psychological status and physical and sexual abuse history in female idiopathic gastroparesis patients were ascertained and an association between those factors and gastrointestinal symptomatology was sought. Eighty-two percent of patients were females (mean age: 45 years old). The mean age for onset of gastroparesis was 33.7 years. The etiologies in 146 patients are: 36% idiopathic, 29% diabetic, 13% postgastric surgery, 7.5% Parkinson's disease, 4.8% collagen vascular disorders, 4.1% intestinal pseudoobstruction, and 6% miscellaneous causes. Subgroups were identified within the idiopathic group: 12 patients (23%) had a presentation consistent with a viral etiology, 48% had very prominent abdominal pain. Other subgroups were gastroesophageal reflux disease and nonulcer dyspepsia (19%), depression (23%), and onset of symptoms immediately after cholecystectomy (8%). Sixty-two percent of women with idiopathic gastroparesis reported a history of physical or sexual abuse, and physical abuse was significantly associated with abdominal pain, somatization, depression, and lifetime surgeries. At the end of the follow-up period, 74% required continuous…
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“In case series, estimated mortality rates in patients with gastroparesis range from 38% at 4 years to 34% at 25 years (28–33).”
From Diabetic Gastroparesis. (2019) · cites this paper as [29]
In the citing paper
“In diabetes, chronic hyperglycemia, and reduced trophic factors, in particular the reduction of KIT/stem cell factor (SCF), cause the loss or dysfunction of ICCs [52], leading to dysregulated gastric emptying [4, 19, 53].”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [53]
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“In diabetes, insulin and IGF-1 deficiency causes muscle atrophy and reduced SCF production, leading to ICC depletion and impaired neuromuscular transmission [52–60].”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [53]
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Metadata
- Authors
- Soykan, I., Sivri, B., Sarosiek, I., Kiernan, B., & Mccallum, R. W.
- ORCID
- Mccallum, Richard W.
- Venue
- Digestive Diseases and Sciences
- Published
- 1998-11
- Volume
- 43
- Issue
- 11
- Pages
- 2398-2404
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W1502294688
- Cited by
- 575
- References
- 23
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 15 · 2023: 24 · 2022: 24 · 2021: 24 · 2020: 42 · 2019: 36 · 2018: 21 · 2017: 26 · 2016: 26 · 2015: 30 · 2014: 20 · 2013: 31 · 2012: 28
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (M01RR000847)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Keywords
- gastroparesis, idiopathic gastroparesis, gastric emptying, physical abuse, sexual abuse, depression, somatization, abdominal pain, prokinetic therapy, treatment response, long-term outcomes, Parkinson's disease, connective tissue diseases, viral etiology, gastroesophageal reflux disease, functional dyspepsia, cholecystectomy, gastric electrical stimulation
- MeSH terms
- Adolescent, Adult, Aged, Combined Modality Therapy, Demography, Disease Susceptibility, Female, Follow-Up Studies, Gastric Emptying, Humans, Male, Middle Aged, Psychometrics, Time Factors, Battered Women, Gastroparesis, Statistics, Nonparametric
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