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Cited by 219Aldose Reductase and TaurineImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 44 of the 46 references it cites were found in a registry or an index.

Taurine and Its Chloramine: Modulators of Immunity

Schuller-Levis, Georgia B., Park, Eunkyue·2004·Neurochemical Research
DOI 10.1023/b:nere.0000010440.37629.17
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Abstract

Taurine is a semiessential amino acid that is not incorporated into proteins. In mammalian tissues, taurine is ubiquitous and is the most abundant free amino acid in the heart, retina, skeletal muscle, and leukocytes. Taurine reaches up to 50 mM concentration in leukocytes. Taurine has been shown to be tissue-protective in many models of oxidant-induced injury. One possibility is that taurine reacts with HOCl, produced by the myeloperoxidase (MPO) pathway, to produce the more stable but less toxic taurine chloramine (Tau-Cl). However, data from several laboratories demonstrate that Tau-Cl is a powerful regulator of the immune system. Specifically, Tau-Cl has been shown to downregulate the production of proinflammatory mediators in both rodent and human leukocytes. Recent molecular studies on the function of taurine provide evidence that taurine is a constituent of biological macromolecules. Specifically, two novel taurine-containing modified uridines have been found in both human and bovine mitrochondria. In studies on mechanism of action, Tau-Cl inhibits the activation of NFkappaB, a potent signal transducer for inflammatory cytokines, by oxidation of IkappaB alpha at methionine45. Taurine transporter knockout mice show reduced taurine, reduced fertility, and loss of vision resulting from severe retinal degeneration, which was found to be due to apoptosis. Apoptosis induced by amino chloramines is a current and important finding because oxidants derived from leukocytes play a key role in killing pathogens. The fundamental importance of taurine in adaptive and acquired immunity will be revealed using genetic manipulation.

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Crossref · 10.1023/b:nere.0000010440.37629.17

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44 of 44 references verified0 citation errors · 0 not checkable

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  • Taurine and HOCl form taurine chloramine, a more stable and weaker oxidant.

    “Taurine present in human plasma and cells and HOCl form taurine chloramine (-O3SCH2CH2NHCl), a more stable and weaker oxidant [154].”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [154]

Citations

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2 of the 46 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. Schuller-Levis, G., Mehta, P. D., Rudelli, R., and Sturman, J. 1990. Immunologic consequences of taurine deficiency in cats. J. Leukoc. Biol. 47:321–331. · DOI
  2. Gordon, R. E., Shaked, A. A., and Solano, D. F. 1986. Taurine protects hamster bronchioles from acute NO2-induced alterations. Am. J. Pathol. 125:585–600.

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Metadata

Authors
Schuller-Levis, G. B., & Park, E.
Venue
Neurochemical Research
Publisher
Springer Science and Business Media LLC
Published
2004-01
Volume
29
Issue
1
Pages
117-126
ISSN
  • 0364-3190 (ISSN-L)
  • 1573-6903
DOI
10.1023/b:nere.0000010440.37629.17
OpenAlex
W2000302315
Cited by
219
References
46
Citations by year
2026: 6 · 2025: 5 · 2024: 8 · 2023: 3 · 2022: 14 · 2021: 17 · 2020: 13 · 2019: 13 · 2018: 10 · 2017: 11 · 2016: 11 · 2015: 9 · 2014: 12 · 2013: 12 · 2012: 15
FWCI
0.22
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neurochemical Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • BT Group
  • National Institutes of Health (5r01hl049942-03)
  • National Heart, Lung, and Blood Institute (HL 49942)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
taurine, taurine chloramine, immune regulation, leukocytes, myeloperoxidase, hypochlorous acid, NF-κB, pro-inflammatory mediators, oxidative stress, apoptosis, taurine transporter, retinal degeneration, adaptive immunity
MeSH terms
Taurine Transporters, Animals, Carrier Proteins, Humans, Immunity, Membrane Glycoproteins, Taurine, Models, Animal, Membrane Transport Proteins

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