Cited by 340Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

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Mechanisms of cellular senescence in human and mouse cells.

Itahana, Koji, Campisi, Judith, Dimri, Goberdhan P.·2004·Biogerontology

DOI 10.1023/b:bgen.0000017682.96395.10

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Abstract

Telomere erosion is considered to be the main cause of the onset of replicative senescence. However, recent findings suggest that a senescent phenotype can be induced by a variety of other stimuli that act independently of telomeres. Moreover, telomere-dependent replicative senescence depends on the species of cell origin, in particular whether cells are of human or rodent origin. In addition, the tissue of origin may also dictate the pathway by which cells undergo replicative senescence. In this Review article, we categorize cellular senescence into two types, which for simplicity we term intrinsic or extrinsic senescence, focus on the differences between human and mouse cells, and discuss the roles of the p53 and pRb tumor suppressor pathways in cellular senescence.

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Authors: Itahana, K., Campisi, J., & Dimri, G. P.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Lawrence Berkeley National Laboratory (US)
Corresponding author: Dimri, Goberdhan P.
ORCID: Itahana, Koji
Campisi, Judith
Dimri, Goberdhan P.
Venue: Biogerontology
Publisher: Springer Science and Business Media LLC
Published: 2004-02
Volume: 5
Issue: 1
Pages: 1-10
ISSN: 1389-5729 (ISSN-L)
1573-6768
DOI: 10.1023/b:bgen.0000017682.96395.10
OpenAlex: W2036676765
Cited by: 338
References: 83
Citations by year: 2026: 5 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 19 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 16 · 2015: 14 · 2014: 13 · 2013: 23 · 2012: 19
FWCI: 2.63
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Biogerontology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: cellular senescence, replicative senescence, telomere shortening, p53 pathway, pRb pathway, tumor suppressor pathways, tissue of origin, senescence mechanisms
MeSH terms: Animals, Humans, Nuclear Proteins, Proto-Oncogene Proteins, Repressor Proteins, Tumor Suppressor Protein p53, Retinoblastoma Protein, Telomere, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Mice, Polycomb Repressive Complex 1

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Mechanisms of cellular senescence in human and mouse cells.

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