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Cited by 66Iron Metabolism and DisordersTrace Elements in HealthNeurological diseases and metabolism

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Hemochromatosis and the enigma of misplaced iron: Implications for infectious disease and survival

Moalem, Sharon, Weinberg, Eugene D., Percy, Maire E.·2004·BioMetals
DOI 10.1023/b:biom.0000018375.20026.b3
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Abstract

The mystery surrounding the apparent lack of iron within the macrophages of individuals with hereditary hemochromatosis, a condition of excessive uptake of dietary iron, has yet to be fully explained. We have suggested that iron deficiency of macrophages in people with hereditary hemochromatosis mutations is associated with increased resistance to infection by Yersinia and other intracellular pathogens, a selection pressure resulting in unusually high current population frequencies of hereditary hemochromatosis mutations. Such selection pressure has been called Epidemic Pathogenic Selection (EPS). In support of the theory of EPS, a considerable number of virulent species of bacteria multiply mainly in iron-rich macrophages of their mammalian hosts. Among these fastidious pathogens are strains of Chlamydia, Coxiella, Francisella, Legionella, Mycobacterium, Salmonella and Yersinia. Iron deficiency of macrophages of persons with hereditary hemochromatosis gene mutations may result in increased resistance to members of these bacterial pathogens. People with genes that result in hereditary hemochromatosis may be protected against coronary artery disease associated with Chlamydia and Coxiella infection in the absence of iron overload. In the clinical setting, when a patient appears to be iron deficient, the reason for this should be carefully evaluated. Iron supplementation may adversely affect the health of individuals who have mounted an acute phase response to infection, injury or stress, or who carry genes predisposing them to iron overload disorders.

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Crossref · 10.1023/b:biom.0000018375.20026.b3

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Research works printed but not linked: 1

  1. Moalem S, Somerville MJ, O'Brien L et al. 2002 Parkinson disease and hereditary hemochromatosis mutations in a Swedish sample. Conference Proceedings of the 7th International Symposium on Metal Ions in Biology and Medicine, Saint Petersburg, Russia 7, 399-401.

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Metadata

Authors
Moalem, S., Weinberg, E. D., & Percy, M. E.
Affiliations
  • University of Toronto (CA)
  • Indiana University (US)
Corresponding author
Moalem, Sharon
Venue
BioMetals
Publisher
Springer Science and Business Media LLC
Published
2004-04
Volume
17
Issue
2
Pages
135-139
ISSN
  • 0966-0844 (ISSN-L)
  • 1572-8773
DOI
10.1023/b:biom.0000018375.20026.b3
OpenAlex
W1983507232
Cited by
66
References
32
Citations by year
2022: 3 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
FWCI
3.18
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • BioMetals (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
hereditary hemochromatosis, iron overload, Yersinia, intracellular bacterial pathogens, infection resistance, chlamydia, Coxiella, Francisella, Legionella, Mycobacterium, Salmonella, coronary artery disease, iron supplementation, acute phase response
MeSH terms
Bacterial Infections, Coronary Disease, Hemochromatosis, Humans, Iron, Macrophages, Siderosis

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