The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Lactoferrin and host defence: an overview of its immuno-modulating and anti-inflammatory properties
Abstract
Lactoferrin is a member of the transferrin family of iron-binding glycoproteins that is abundantly expressed and secreted from glandular epithelial cells. In secretions, such as milk and fluids of the intestinal tract, lactoferrin is an important component of the first line of host defence. During the inflammatory process, lactoferrin, a prominent component of the secondary granules of neutrophils (PMNs), is released in infected tissues and in blood and then it is rapidly cleared by the liver. In addition to the antimicrobial properties of lactoferrin, a set of studies has focused on its ability to modulate the inflammatory process and the overall immune response. Though many in vitro and in vivo studies report clear regulation of the immune response and protective effect against infection and septic shock by lactoferrin, elucidation of all the cellular and molecular mechanisms of action is far from being achieved. At the cellular level, lactoferrin modulates the migration, maturation and function of immune cells. At the molecular level and in addition to iron binding, interactions of lactoferrin with a plethora of compounds, either soluble or membrane molecules, account for its modulatory properties. This paper reviews our current understanding of the cellular and molecular mechanisms that explain the regulatory properties of lactoferrin in host defence.
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“Neutrophils further limit nutrient metal availability by releasing lactoferrin to sequester iron (Legrand et al., 2004)”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Legrand et al., 2004
In the citing paper
“Both target free Fe3+, 122 and can therefore reduce its availability.”
From The battle for iron in enteric infections (2020) · cites this paper as [122]
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The battle for iron in enteric infections
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Metadata
- Authors
- Legrand, D., Elass, E., Pierce, A., & Mazurier, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Legrand, Dominique
- Venue
- Biometals
- Published
- 2004-06
- Volume
- 17
- Issue
- 3
- Pages
- 225-229
- ISSN
- 0966-0844 (ISSN-L)
- 1572-8773
- OpenAlex
- W1996525939
- Cited by
- 149
- References
- 57
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 12 · 2016: 1 · 2015: 4 · 2014: 11 · 2013: 5 · 2012: 11
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- BioMetals (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- lactoferrin, host defense, immunomodulation, anti-inflammatory activity, iron-binding glycoprotein, antimicrobial activity, leukocyte migration, immune cell maturation, septic shock, innate immunity
- MeSH terms
- Animals, Anti-Infective Agents, Anti-Inflammatory Agents, Humans, Immune System, Immunologic Factors, Lactoferrin
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