Lactoferrin: Multifunctional roles of lactoferrin: a critical overview
Open accessAbstract
Lactoferrin (LF) is a member of the transferrin family that is expressed and secreted by glandular epithelial cells and is found in the secondary granules of neutrophils. Originally viewed as an iron-binding protein in milk, with bacteriostatic properties, it is becoming increasingly evident that LF is a multifunctional protein to which several physiological roles have been attributed. These include regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. While iron binding is likely central to some of the biological roles of LF, other activities, including specific interactions with mammalian receptors and microbial components, also contribute to the pleoitropic functional nature of this protein. In this article, recent advances in the understanding of these functions at the cellular and molecular level are discussed.
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Asthmatics have a deficient IFN-beta and IFN-lambda response to rhinovirus infection.
“The importance of IFN responses to respiratory viruses by the airway epithelium is underscored by studies of asthmatics which suggest that these patients have a deficient IFN-β and IFN-λ response to rhinovirus infection (35, 310).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [310]
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- Authors
- Ward, P. P., Paz, E., & Conneely, O. M.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Conneely, O. M.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2005-11
- Volume
- 62
- Issue
- 22
- Pages
- 2540-2548
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11139086
- OpenAlex
- W2469414933
- Cited by
- 443
- References
- 136
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 14 · 2023: 19 · 2022: 14 · 2021: 25 · 2020: 22 · 2019: 22 · 2018: 20 · 2017: 19 · 2016: 12 · 2015: 21 · 2014: 23 · 2013: 28 · 2012: 32
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- lactoferrin, transferrin family, iron-binding proteins, iron homeostasis, bacteriostatic activity, anti-inflammatory activity, cancer protection, metastasis, milk, receptor interaction
- MeSH terms
- Animals, Humans, Lactoferrin, Structure-Activity Relationship
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