Cited by 443Antimicrobial Peptides and ActivitiesIron Metabolism and DisordersInfant Nutrition and Health

Lactoferrin: Multifunctional roles of lactoferrin: a critical overview

Open access
Ward, P. P., Paz, E., Conneely, O. M.·2005·Cellular and Molecular Life Sciences

Abstract

Lactoferrin (LF) is a member of the transferrin family that is expressed and secreted by glandular epithelial cells and is found in the secondary granules of neutrophils. Originally viewed as an iron-binding protein in milk, with bacteriostatic properties, it is becoming increasingly evident that LF is a multifunctional protein to which several physiological roles have been attributed. These include regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. While iron binding is likely central to some of the biological roles of LF, other activities, including specific interactions with mammalian receptors and microbial components, also contribute to the pleoitropic functional nature of this protein. In this article, recent advances in the understanding of these functions at the cellular and molecular level are discussed.

Integrity signals

Registry

Crossref · 10.1007/s00018-005-5369-8

Cites

136 of 136 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Asthmatics have a deficient IFN-beta and IFN-lambda response to rhinovirus infection.

    “The importance of IFN responses to respiratory viruses by the airway epithelium is underscored by studies of asthmatics which suggest that these patients have a deficient IFN-β and IFN-λ response to rhinovirus infection (35, 310).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Ward, P. P., Paz, E., & Conneely, O. M.
Affiliations
Baylor College of Medicine (US)
Corresponding author
Conneely, O. M.
Venue
Cellular and Molecular Life Sciences
Published
2005-11
Volume
62
Issue
22
Pages
2540-2548
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2469414933
Cited by
443
References
136
Citations by year
2026: 6 · 2025: 14 · 2024: 14 · 2023: 19 · 2022: 14 · 2021: 25 · 2020: 22 · 2019: 22 · 2018: 20 · 2017: 19 · 2016: 12 · 2015: 21 · 2014: 23 · 2013: 28 · 2012: 32
FWCI
15.89
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords
lactoferrin, transferrin family, iron-binding proteins, iron homeostasis, bacteriostatic activity, anti-inflammatory activity, cancer protection, metastasis, milk, receptor interaction
MeSH terms
Animals, Humans, Lactoferrin, Structure-Activity Relationship

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review