Localization of microtubule-associated protein (MAP) 1B in the postsynaptic densities of the rat cerebral cortex
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1. Although microtubule-associated protein (MAP) 1B and its phosphorylation have been suggested to be important for synapse formation among cortical neurons, the localization of MAP1B in synapses has not yet been confirmed. In this report, we examine the localization of MAP1B in synaptic regions. 2. The localization of MAP1B was observed by immunohistochemical and electron microscopic techniques using specific antibodies against MAP1B. 3. MAP1B immunoreactivities were widely distributed in the cerebral cortex and were observed in the postsynaptic area but not in presynaptic terminals. 4. These synapses were classified as the asymmetrical type. 5. Only some synapses exhibited MAP1B immunoreactivities. MAP1B-immunopositive synapses accounted for about half of the total synapses. 6. Such a localization suggests MAP1B's important roles in synaptic functions.
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Loss of certain cytoskeletal proteins appears to be a common mechanism in AD, PD, and ALS, whereas AD-specific modules are linked to loss of a select group of microtubule and related proteins represented by hubs MAP1B (E-M10) and DNM3 (E-M20).
“Thus, loss of certain cytoskeletal proteins appears to be a common mechanism in AD, PD, and ALS, whereas AD-specific modules are linked to a loss of a select group of microtubule and related proteins represented respectively by hubs MAP1B (E-M10) and DNM3 (E-M20) (Gray et al., 2003; Kawakami et al., 2003).”
From A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease (2017) · cites this paper as Kawakami et al., 2003
Cites
Zhang, Y., Bailey, A. M., Matthies, H. J. G., Renden, R., Smith, M. A., Speese, S. D., Rubin, G. M., & Broadie, K. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00589-x · Cited by 641 · see citing works
Drosophila Futsch/22C10 Is a MAP1B-like Protein Required for Dendritic and Axonal Development
Hummel, T., Krukkert, K., Roos, J., Davis, G. W., & Klämbt, C. (2000) · Neuron · doi:10.1016/s0896-6273(00)81169-1 · Cited by 464 · see citing works
The Ferrier Lecture, 1977 The neuron network of the cerebral cortex: a functional interpretation
Szentágothai, J. (1978) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1978.0043 · Cited by 416 · see citing works
Drosophila Futsch Regulates Synaptic Microtubule Organization and Is Necessary for Synaptic Growth
Roos, J., Hummel, T., Ng, N., Klämbt, C., & Davis, G. W. (2000) · Neuron · doi:10.1016/s0896-6273(00)81170-8 · Cited by 375 · see citing works
Nieuwenhuys, R. (1994) · Anatomy and Embryology · doi:10.1007/bf00187291 · Cited by 274 · see citing works
Microtubule-associated protein 1B: identification of a major component of the neuronal cytoskeleton.
Bloom, G. S., Luca, F. C., & Vallee, R. B. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.16.5404 · Cited by 202 · see citing works
Sato-Yoshitake, R., Shiomura, Y., Miyasaka, H., & Hirokawa, N. (1989) · Neuron · doi:10.1016/0896-6273(89)90036-6 · Cited by 188 · see citing works
Synapse restructuring associated with the maintenance phase of hippocampal long-term potentiation
Geinisman, Y., deToledo‐Morrell, L., Morrell, F., Persina, I. S., & Beatty, M. A. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960506)368:3 · Cited by 140 · see citing works
The protein MAP-1B links GABAC receptors to the cytoskeleton at retinal synapses
Hanley, J. G., Koulen, P., Bedford, F. K., Gordon‐Weeks, P. R., & Moss, S. J. (1999) · Nature · doi:10.1038/16258 · Cited by 136 · see citing works
Brugg, B., Reddy, D., & Matus, A. I. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90401-z · Cited by 132 · see citing works
Calvert, R. A., & Anderton, B. H. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03756.x · Cited by 125 · see citing works
Muramoto, K., Ichikawa, M., Kawahara, M., Kobayashi, K., & Kuroda, Y. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90372-r · Cited by 113 · see citing works
Self-citationThe distribution and phosphorylation of the microtubule-associated protein MAP 1B in growth cones
Mansfield, S. G., Díaz‐Nido, J., Gordon‐Weeks, P. R., & Ávila, J. (1991) · Journal of Neurocytology · doi:10.1007/bf01187918 · Cited by 86 · see citing works
Tanaka, Y., Kawahata, K., Nakata, T., & Hirokawa, N. (1992) · Brain Research · doi:10.1016/0006-8993(92)91557-u · Cited by 52 · see citing works
Block of synapse formation between cerebral cortical neurons by a protein kinase inhibitor
Kuroda, Y., Ichikawa, M., Muramoto, K., Kobayashi, K., Matsuda, Y., Ogura, A., & Kudo, Y. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90449-h · Cited by 52 · see citing works
Self-citationClaustrin, an antiadhesive neural keratan sulfate proteoglycan, is structurally related to MAP1B
Burg, M. A., & Cole, G. J. (1994) · Journal of Neurobiology · doi:10.1002/neu.480250102 · Cited by 51 · see citing works
GABACReceptor Sensitivity Is Modulated by Interaction with MAP1B
Billups, D., Hanley, J. G., Orme, M. H., Attwell, D., & Moss, S. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08643.2000 · Cited by 49 · see citing works
Nagashima, K., Nakanishi, S., & Matsuda, Y. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81165-5 · Cited by 47 · see citing works
An Analysis of an Axonal Gradient of Phosphorylated MAP 1B in Cultured Rat Sensory Neurons
Bush, M. S., Goold, R., Moya, F., & Gordon‐Weeks, P. R. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01208.x · Cited by 42 · see citing works
The Mouse and Rat MAP1B Genes: Genomic Organization and Alternative Transcription
Kutschera, W., Zauner, W., Wiche, G., et al. (1998) · Genomics · doi:10.1006/geno.1998.5294 · Cited by 41 · see citing works
Lien, L. L., Feener, C. A., Fischbach, N. A., et al. (1994) · Genomics · doi:10.1006/geno.1994.1384 · Cited by 38 · see citing works
Muramoto, K., Taniguchi, H., Kawahara, M., et al. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2830 · Cited by 31 · see citing works
Self-citationYamauchi, E., Titani, K., & Taniguchi, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22948 · Cited by 27 · see citing works
Pedrotti, B., Francolini, M., Cotelli, F., et al. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00308-0 · Cited by 20 · see citing works
Molecular genetic approaches to microtubule-associated protein function.
González‐Billault, C., & Ávila, J. (2000) · PubMed · doi:10.14670/hh-15.1177 · Cited by 19 · see citing works
Burg, M. A., Lee, J., & Cole, G. J. (1997) · Journal of Molecular Neuroscience · doi:10.1007/bf02800500 · Cited by 9 · see citing works
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- Authors
- Kawakami, S.-I., Muramoto, K., Ichikawa, M., & Kuroda, Y.
- Affiliations
- Nagoya University (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Muramoto, Kazuyo
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2003-12
- Volume
- 23
- Issue
- 6
- Pages
- 887-894
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC11530180
- OpenAlex
- W2019274374
- Cited by
- 25
- References
- 26
- Citations by year
- 2019: 1 · 2017: 1 · 2016: 3 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- MAP1B, postsynaptic density, cerebral cortex, synaptogenesis, synaptic localization, asymmetrical synapses, cortical neurons, synaptic function
- MeSH terms
- Animals, Cell Count, Cerebral Cortex, Male, Microtubule-Associated Proteins, Synapses, Rats, Wistar, Rats
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