The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Crohn's Disease: A Two-Year Prospective Study of the Association Between Psychological Distress and Disease Activity
Abstract
Our objective was to explore the relationship between psychological distress and subsequent Crohn's disease (CD) activity. Eighteen CD patients were followed prospectively for 2 years at 8- to 12-week intervals. Disease activity was assessed using the Crohn's Disease Activity Index (CDAI). Psychological distress was assessed using the following self-administered questionnaires: Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Beck Hopelessness Scale (BHS), and multiple Holmes Recent Life Changes (RLC) Questionnaires. The effects of psychological distress on current and subsequent CDAI (approximately 8-12 weeks later) were assessed using generalized estimating equations (GEE). The mean CDAI score during follow-up was 138 +/- 86, with a median of 121 (range, 0 to 394). BDI scores (possible range of 0 to 63) were independently associated with CDAI scores simultaneously (beta = 5.64, P = 0.004) and 8-12 weeks later (beta = 6.08, P = 0.004). Higher levels of anxiety, hopelessness, and recent life changes were also suggestive of higher CDAI scores, however, their effects were generally of lesser magnitude and not independent of the influence of depressive symptoms. Levels of depressive symptoms are positively associated with future changes in CDAI. Routine psychological assessment may help to identify patients at higher risk for exacerbation.
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“but when distress was measured with separate depression, anxiety and hopelessness indices, depression was associated with disease exacerbation 8–12 weeks later. 47”
From Systematic review: the role of psychological stress in inflammatory bowel disease (2022) · cites this paper as [47]
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Cites
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Life changes scaling for the 1990s
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Screening for Depression in Diabetes Using the Beck Depression Inventory
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Buijs, R. M. (2008) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1125937.583046
El‐Chammas, K. I., & Sood, M. R. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5061-0_46
CROHN'S DISEASE: AETIOLOGY, PATHOLOGY, DIAGNOSIS AND MEDICAL TREATMENT
(2008) · Elsevier eBooks · doi:10.1016/b978-0-7020-2723-9.50047-6
Basilisco, G., Viganò, C., & Caprioli, F. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1125937.719058
Psychosocial Issues in Inflammatory Bowel Disease and Intestinal Failure
Franklin, J. (2007) · The American Journal of Gastroenterology · doi:10.14309/00000434-200706001-00013
Gastrointestinale Erkrankungen
Kapfhammer, H. (2022) · Springer eBooks · doi:10.1007/978-3-662-65873-4_6
Irritable Bowel Syndrome and Functional GI Disorders in Inflammatory Bowel Disease
El‐Chammas, K. I., & Sood, M. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-14744-9_52
Salud mental y enfermedad inflamatoria intestinal
Muñoz, T. M. (2025) · Diversitas · doi:10.15332/22563067.11084
Festő, B., Rafael, B., Molnár, Á., Szűcs, T., Csuka, S. I., Sanela, T.-N., Dávid, A., Horvát, B., Sallay, V., Molnár, T., et al. (2026) · Frontiers in Digital Health · doi:10.3389/fdgth.2026.1710921
Peris, M. A. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Metadata
- Authors
- Mardini, H. E., Kip, K. E., & Wilson, J. W.
- Affiliations
- University of Kentucky (US)
- University of Pittsburgh (US)
- Corresponding author
- Mardini, Houssam E.
- ORCID
- Kip, Kevin E.
- Venue
- Digestive Diseases and Sciences
- Published
- 2004-03
- Volume
- 49
- Issue
- 3
- Pages
- 492-497
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2142347208
- Cited by
- 211
- References
- 40
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 12 · 2020: 9 · 2019: 13 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 8 · 2014: 6 · 2013: 11 · 2012: 7
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- Crohn's disease, psychological distress, disease activity, depressive symptoms, anxiety, hopelessness, CDAI, disease exacerbation, psychological assessment
- MeSH terms
- Adult, Anxiety, Crohn Disease, Depression, Female, Humans, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Stress, Psychological
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