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Cited by 211Inflammatory Bowel DiseaseTryptophan and brain disordersPsychosomatic Disorders and Their Treatments

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Crohn's Disease: A Two-Year Prospective Study of the Association Between Psychological Distress and Disease Activity

Mardini, Houssam E., Kip, Kevin E., Wilson, John W.·2004·Digestive Diseases and Sciences
DOI 10.1023/b:ddas.0000020509.23162.cc
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Abstract

Our objective was to explore the relationship between psychological distress and subsequent Crohn's disease (CD) activity. Eighteen CD patients were followed prospectively for 2 years at 8- to 12-week intervals. Disease activity was assessed using the Crohn's Disease Activity Index (CDAI). Psychological distress was assessed using the following self-administered questionnaires: Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Beck Hopelessness Scale (BHS), and multiple Holmes Recent Life Changes (RLC) Questionnaires. The effects of psychological distress on current and subsequent CDAI (approximately 8-12 weeks later) were assessed using generalized estimating equations (GEE). The mean CDAI score during follow-up was 138 +/- 86, with a median of 121 (range, 0 to 394). BDI scores (possible range of 0 to 63) were independently associated with CDAI scores simultaneously (beta = 5.64, P = 0.004) and 8-12 weeks later (beta = 6.08, P = 0.004). Higher levels of anxiety, hopelessness, and recent life changes were also suggestive of higher CDAI scores, however, their effects were generally of lesser magnitude and not independent of the influence of depressive symptoms. Levels of depressive symptoms are positively associated with future changes in CDAI. Routine psychological assessment may help to identify patients at higher risk for exacerbation.

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Metadata

Authors
Mardini, H. E., Kip, K. E., & Wilson, J. W.
Affiliations
  • University of Kentucky (US)
  • University of Pittsburgh (US)
Corresponding author
Mardini, Houssam E.
ORCID
Kip, Kevin E.
Venue
Digestive Diseases and Sciences
Publisher
Springer Science and Business Media LLC
Published
2004-03
Volume
49
Issue
3
Pages
492-497
ISSN
  • 0163-2116 (ISSN-L)
  • 1573-2568
DOI
10.1023/b:ddas.0000020509.23162.cc
OpenAlex
W2142347208
Cited by
211
References
40
Citations by year
2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 12 · 2020: 9 · 2019: 13 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 8 · 2014: 6 · 2013: 11 · 2012: 7
FWCI
6.35
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Digestive Diseases and Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
Crohn's disease, psychological distress, disease activity, depressive symptoms, anxiety, hopelessness, CDAI, disease exacerbation, psychological assessment
MeSH terms
Adult, Anxiety, Crohn Disease, Depression, Female, Humans, Male, Middle Aged, Prospective Studies, Surveys and Questionnaires, Stress, Psychological

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