Psychological stress in IBD: new insights into pathogenic and therapeutic implications

Mawdsley, J E; Rampton, D S

doi:10.1136/gut.2005.064261

Cited by 622Inflammatory Bowel DiseaseStress Responses and CortisolTryptophan and brain disorders

Psychological stress in IBD: new insights into pathogenic and therapeutic implications

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Mawdsley, J E, Rampton, D S·2005·Gut

DOI 10.1136/gut.2005.064261PMC PMC1774724

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Abstract

Psychological stress has long been reported anecdotally to increase disease activity in inflammatory bowel disease (IBD), and recent well designed studies have confirmed that adverse life events, chronic stress, and depression increase the likelihood of relapse in patients with quiescent IBD. This evidence is increasingly supported by studies of experimental stress in animal models of colitis. With the evolving concept of psychoneuroimmunology, the mechanisms by which the nervous system can affect immune function at both systemic and gut mucosal levels are gradually becoming apparent. Recent data suggest that stress induced alterations in gastrointestinal inflammation may be mediated through changes in hypothalamic-pituitary-adrenal (HPA) axis function and alterations in bacterial-mucosal interactions, and via mucosal mast cells and mediators such as corticotrophin releasing factor (CRF). To date, the therapeutic opportunities offered by stress reduction therapy remain largely unexplored, in part because of methodological difficulties of such studies. This paper reviews recent advances in our understanding of the pathogenic role of psychological stress in IBD and emphasises the need for controlled studies of the therapeutic potential of stress reduction.

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Stress is thought to activate the hypothalamic-pituitary-adrenal (HPA) axis which has been implicated in gastrointestinal inflammation.
“Stress is thought to activate the hypothalamic–pituitary–adrenal (HPA) axis which has been implicated in gastrointestinal inflammation, 59”
From Systematic review: the role of psychological stress in inflammatory bowel disease (2022) · cites this paper as [59]
IBD patients are often exposed to stress, which induces mood swings or even leads to mental complications.
“Specifically, IBD patients are often exposed to stress, which induces mood swings or even leads to mental complications.”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [54]

Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · PubMed · Cited by 3,147 · see citing works
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689 · see citing works
A simple clinical colitis activity index
Walmsley, R. S., Ayres, R., Pounder, R. E., & Allan, R. N. (1998) · Gut · doi:10.1136/gut.43.1.29 · Cited by 1,320 · see citing works
CRF and CRF receptors: role in stress responsivity and other behaviors
Bale, T. L., & Vale, W. W. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121410 · Cited by 1,270 · see citing works
Neuroendocrine pharmacology of stress
Carrasco, G. A., & Van de Kar, L. D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01285-8 · Cited by 914 · see citing works
Psychoneuroimmunology: interactions between the nervous system and the immune system
Ader, R., Cohen, N., & Felten, D. L. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90066-7 · Cited by 800 · see citing works
The role of substance P in inflammatory disease
O’Connor, T. M., O'Connell, J., O’Brien, D. I., Goode, T., Bredin, C. P., & Shanahan, F. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20061 · Cited by 789 · see citing works
PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis
Loftus, E. V., Harewood, G. C., Loftus, C. G., Tremaine, W. J., Harmsen, W. S., Zinsmeister, A. R., Jewell, D. A., & Sandborn, W. J. (2005) · Gut · doi:10.1136/gut.2004.046615 · Cited by 777 · see citing works
The Enteric Nervous System
Goyal, R. K., & Hirano, I. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604253341707 · Cited by 774 · see citing works
THE EFFECTS OF PSYCHOLOGICAL STRESS ON HUMANS: INCREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND Th1-LIKE RESPONSE IN STRESS-INDUCED ANXIETY
Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., et al. (1998) · Cytokine · doi:10.1006/cyto.1997.0290 · Cited by 772 · see citing works
The neurobiology of stress and gastrointestinal disease
MAYER, E. A. (2000) · Gut · doi:10.1136/gut.47.6.861 · Cited by 666 · see citing works
Sex-Specific Effects of Social Support on Cortisol and Subjective Responses to Acute Psychological Stress
Kirschbaum, C., Klauer, T., Filipp, S., & Hellhammer, D. H. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199501000-00004 · Cited by 583 · see citing works
A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall-induced arthritis in Lewis rats.
Sternberg, E. M., Young, W. S., Bernardini, R., Calogero, A. E., Chrousos, G. P., Gold, P. W., & Wilder, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4771 · Cited by 573 · see citing works
Neuroendocrine-Immune Interactions
Epstein, F. H., & Reichlin, S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199310213291708 · Cited by 564 · see citing works
CONTROLLED TRIAL OF HYPNOTHERAPY IN THE TREATMENT OF SEVERE REFRACTORY IRRITABLE-BOWEL SYNDROME
Whorwell, P. J., Prior, A., & Faragher, E. B. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92793-4 · Cited by 537 · see citing works
Impact of depressive mood on relapse in patients with inflammatory bowel disease: A prospective 18-month follow-up study
Mittermaier, C., Dejaco, C., Waldhoer, T., Oefferlbauer-Ernst, A., Miehsler, W., Beier, M., Tillinger, W., Gangl, A., & Moser, G. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000106907.24881.f2 · Cited by 532 · see citing works
Transdermal Nicotine for Active Ulcerative Colitis
Pullan, R. D., Rhodes, J., Ganesh, S., Mani, V., Morris, J. S., Williams, G. T., Newcombe, R. G., Russell, M., Feyerabend, C., Thomas, G., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403243301202 · Cited by 505 · see citing works
Stress and the gastrointestinal tract
Bhatia, V., & Tandon, R. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03508.x · Cited by 486 · see citing works
Stress and Exacerbation in Ulcerative Colitis: A Prospective Study of Patients Enrolled in Remission
Levenstein, S., Prantera, C., Varvo, V., Scribano, M. L., Andreoli, A., Luzi, C., Arcà, M., Berto, E., Milite, G., & Marcheggiano, A. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02012.x · Cited by 451 · see citing works
Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease
Sajadieh, A. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.12.003 · Cited by 393 · see citing works
Annual Review of Pharmacology,
Williams, J. F. (1975) · Archives of Internal Medicine · doi:10.1001/archinte.1975.00330100136032 · Cited by 387 · see citing works
Inflammatory bowel disease: Immunodiagnostics, immunotherapeutics, and ecotherapeutics
Shanahan, F. (2001) · Gastroenterology · doi:10.1053/gast.2001.22122 · Cited by 371 · see citing works
Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine
Söderholm, J. D., Yang, P., Ceponis, P., Vohra, A., Riddell, R., Sherman, P. M., & Perdue, M. H. (2002) · Gastroenterology · doi:10.1053/gast.2002.36019 · Cited by 362 · see citing works
Cytokine modulation by glucocorticoids: mechanisms and actions in cellular studies.
Brattsand, R., & Linden, M. (1996) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1996.22164025.x · Cited by 361 · see citing works
Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels
STEPTOE, A., WILLEMSEN, G., OWEN, N., FLOWER, L., & MOHAMED-ALI, V. (2001) · Clinical Science · doi:10.1042/cs1010185 · Cited by 354 · see citing works
III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors
Taché, Y., Martı́nez, V., Million, M., & Wang, L. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.2.g173 · Cited by 347 · see citing works
Association Between Depression and Elevated C-Reactive Protein
Danner, M., Kasl, S. V., Abramson, J. L., & Vaccarino, V. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000041542.29808.01 · Cited by 341 · see citing works
Role of peripheral CRF signalling pathways in stress‐related alterations of gut motility and mucosal function
Taché, Y., & Perdue, M. H. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1743-3150.2004.00490.x · Cited by 281 · see citing works
Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists
Grammatopoulos, D. K., & Chrousos, G. P. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00670-7 · Cited by 277 · see citing works
Parental Depression: Animal Models of an Adverse Life Event
Newport, D. J., Stowe, Z. N., & Nemeroff, C. B. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.8.1265 · Cited by 265 · see citing works
The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis
Qiu, B., Vallance, B. A., Blennerhassett, P. A., & Collins, S. M. (1999) · Nature Medicine · doi:10.1038/13503 · Cited by 252 · see citing works
Hypnotherapy in severe irritable bowel syndrome: further experience.
Whorwell, P. J., Prior, A., & Colgan, S. M. (1987) · Gut · doi:10.1136/gut.28.4.423 · Cited by 252 · see citing works
Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells
Castagliuolo, I., LaMont, J. T., Qiu, B., Fleming, S. M., Bhaskar, K. R., Nikulásson, S. Þ., Kornetsky, C. H., & Pothoulakis, C. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.271.5.g884 · Cited by 251 · see citing works
Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat
Santos, J., Saunders, P. R., Hanssen, N. P. M., Yang, P., Yates, D. A., Groot, J. A., & Perdue, M. H. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.2.g391 · Cited by 251 · see citing works
Chronic Life Stress Alters Sympathetic, Neuroendocrine, and Immune Responsivity to an Acute Psychological Stressor in Humans
Pike, J. L., Smith, T. L., Hauger, R. L., Nicassio, P. M., Patterson, T. L., McClintick, J., Costlow, C., & Irwin, M. R. (1997) · Psychosomatic Medicine · doi:10.1097/00006842-199707000-00015 · Cited by 248 · see citing works
Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress
Söderholm, J. D., Yates, D. A., Gareau, M. G., Yang, P.-C., MacQueen, G., & Perdue, M. H. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00314.2002 · Cited by 243 · see citing works
Release of mast cell mediators into the jejunum by cold pain stress in humans
Santos, J., Saperas, E., Nogueiras, C., Mourelle, M., Antolín, M., Cadahia, A., & Malagelada, J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70577-3 · Cited by 237 · see citing works
Platelets circulate in an activated state in inflammatory bowel disease
Collins, C. E., Cahill, M. R., Newland, A. C., & Rampton, D. S. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90741-2 · Cited by 226 · see citing works
Self-citation
Psychosocial determinants of relapse in ulcerative colitis: A longitudinal study
Bitton, A., Sewitch, M. J., Peppercorn, M. A., de B Edwardes, M. D., Shah, S., Ransil, B., & Locke, S. E. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07717.x · Cited by 226 · see citing works
Stress stimulates transepithelial macromolecular uptake in rat jejunum
Kiliaan, A. J., Saunders, P. R., Bijlsma, P. B., Berin, M. C., Taminiau, J. A., Groot, J. A., & Perdue, M. H. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.5.g1037 · Cited by 223 · see citing works
REPORT OF SEVEN CASES
Flippin, H. F., & SMITH, O. N. (1936) · The American Journal of the Medical Sciences · doi:10.1097/00000441-193612000-00003 · Cited by 216 · see citing works
Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine
Saunders, P. R., Kosecka, U., McKay, D. M., & Perdue, M. H. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.5.g794 · Cited by 215 · see citing works
Crohn's Disease: A Two-Year Prospective Study of the Association Between Psychological Distress and Disease Activity
Mardini, H. E., Kip, K. E., & Wilson, J. W. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000020509.23162.cc · Cited by 211 · see citing works
Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells
Santos, J., Benjamin, M. A., Yang, P., Prior, T., & Perdue, M. H. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.6.g847 · Cited by 205 · see citing works
Stress-induced disruption of colonic epithelial barrier: role of interferon-γ and myosin light chain kinase in mice
Ferrier, L., Mazelin, L., Cénac, N., Desreumaux, P., Janin, A., Émilie, D., Colombel, J., Villar, R. G., Fioramonti, J., & Bueno, L. P. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01057-6 · Cited by 197 · see citing works
Interleukin-6 and tumor necrosis factor-α production after acute psychological stress, exercise, and infused isoproterenol: differential effects and pathways.
Goebel, M. U., Mills, P. J., Irwin, M. R., & Ziegler, M. G. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200007000-00019 · Cited by 189 · see citing works
Psychological stress and disease activity in ulcerative colitis: a multidimensional cross-sectional study.
Levenstein, S., Prantera, C., Varvo, V., Scribano, M. L., Berto, E., Andreoli, A., & Luzi, C. (1994) · PubMed · Cited by 188 · see citing works
Effect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome
Murray, C. D. R., Flynn, J., Ratcliffe, L., Jacyna, M. R., Kamm, M. A., & Emmanuel, A. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.057 · Cited by 185 · see citing works
Clinical relevance of advances in genetics and pharmacogenetics of IBD
Ahmad, T., Tamboli, C., Jewell, D. P., & Colombel, J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.061 · Cited by 180 · see citing works
Relevance of Major Stress Events as an Indicator of Disease Activity Prevalence in Inflammatory Bowel Disease
Duffy, L. C., Zielezny, M. A., Marshall, J. R., Byers, T. E., Weiser, M. M., Phillips, J. F., Calkins, B. M., Ogra, P. L., & Graham, S. (1991) · Behavioral Medicine · doi:10.1080/08964289.1991.9937553 · Cited by 176 · see citing works
A study of the association between Crohn's disease and psychiatric illness
Helzer, J. E., Chammas, S., Norland, C. C., Stillings, W. A., & Alpers, D. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90418-9 · Cited by 168 · see citing works
How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis
Straub, R. H., Dhabhar, F. S., Bijlsma, J. W. J., & Cutolo, M. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20747 · Cited by 168 · see citing works
Cell-specific regulation of apoptosis by glucocorticoids: implication to their anti-inflammatory action
Amsterdam, A., Tajima, K., & Sasson, R. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01147-4 · Cited by 167 · see citing works
Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa
Muramatsu, Y., Fukushima, K., Iino, K., Totsune, K., Takahashi, K., Suzuki, T., Hirasawa, G., Takeyama, J., Ito, M. R., Nose, M., et al. (2000) · Peptides · doi:10.1016/s0196-9781(00)00335-1 · Cited by 164 · see citing works
Increased epithelial uptake of protein antigens in the ileum of Crohn’s disease mediated by tumour necrosis factor α
Söderholm, J. D., Streutker, C., Yang, P.-C., Paterson, C., Singh, P. K., McKay, D. M., Sherman, P. M., Croitoru, K., & Perdue, M. H. (2004) · Gut · doi:10.1136/gut.2004.041426 · Cited by 160 · see citing works
Personality profile and affective state of patients with inflammatory bowel disease.
Robertson, D. A., Ray, J., Diamond, I., & Edwards, J. (1989) · Gut · doi:10.1136/gut.30.5.623 · Cited by 156 · see citing works
Do Life Events or Depression Exacerbate Inflammatory Bowel Disease?: A Prospective Study
North, C. S., Alpers, D. H., Helzer, J. E., Spitznagel, E. L., & Clouse, R. E. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-5-381 · Cited by 152 · see citing works
Previous inflammation alters the response of the rat colon to stress
Collins, S. M., McHugh, K., Jacobson, K., Khan, I., Riddell, R. H., Murase, K., & Weingarten, H. (1996) · Gastroenterology · doi:10.1016/s0016-5085(96)70012-4 · Cited by 148 · see citing works
Stress-induced enhancement of colitis in rats: CRF and arginine vasopressin are not involved
Gué, M., Bonbonne, C., Fioramonti, J., Moré, J., Rio-Lacheze, C. D., Coméra, C., & Bueno, L. P. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.1.g84 · Cited by 148 · see citing works
Stimulatory effect of corticotropin-releasing neurohormone on human lymphocyte proliferation and interleukin-2 receptor expression
Singh, V. K. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90058-1 · Cited by 146 · see citing works
Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis.
Kawahito, Y., Sano, H., Mukai, S., Asai, K., Kimura, S., Yamamura, Y., Kato, H., Chrousos, G. P., Wilder, R. L., & Kondo, M. (1995) · Gut · doi:10.1136/gut.37.4.544 · Cited by 146 · see citing works
Cardiovascular reactivity and the course of immune response to an acute psychological stressor.
Herbert, T. B., Cohen, S., Marsland, A. L., Bachen, E. A., Rabin, B. S., Muldoon, M. F., & Manuck, S. B. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199407000-00009 · Cited by 143 · see citing works
Psychological and Physical Stress Induce Differential Effects on Human Colonic Motility
Rao, S. S. C., Hatfield, R., Suls, J. M., & Chamberlain, M. J. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.00293.x · Cited by 137 · see citing works
The relation of ulcerative colitis to psychiatric factors: a review of findings and methods
North, C. S., Clouse, R. E., Spitznagel, E. L., & Alpers, D. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.8.974 · Cited by 137 · see citing works
Glucocorticoids and Inflammation Revisited: The State of the Art
Franchimont, D. P., Kino, T., Galon, J., Meduri, G. U., & Chrousos, G. P. (2002) · NeuroImmunoModulation · doi:10.1159/000069969 · Cited by 131 · see citing works
Evaluation of a psychological treatment for inflammatory bowel disease
Schwarz, S. P., & Blanchard, E. B. (1991) · Behaviour Research and Therapy · doi:10.1016/0005-7967(91)90045-5 · Cited by 131 · see citing works
Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats
Velin, Å. K., Ericson, A.-C., Braaf, Y., Wallon, C., & Söderholm, J. D. (2004) · Gut · doi:10.1136/gut.2003.028506 · Cited by 131 · see citing works
Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF
Million, M., Taché, Y., & Anton, P. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.4.g1027 · Cited by 128 · see citing works
Stress effects on gastrointestinal transit in the rat.
Enck, P., Merlin, V., Erckenbrecht, J. F., & WIENBECK, M. (1989) · Gut · doi:10.1136/gut.30.4.455 · Cited by 128 · see citing works
A controlled study of the association between ulcerative colitis and psychiatric diagnoses
Helzer, J. E., Stillings, W. A., Chammas, S., Norland, C. C., & Alpers, D. (1982) · Digestive Diseases and Sciences · doi:10.1007/bf01296730 · Cited by 125 · see citing works
Stressor-Induced Alteration of Cytokine Production in Multiple Sclerosis Patients and Controls
Ackerman, K. D., Martino, M., Heyman, R. A., Moyna, N. M., & Rabin, B. S. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199807000-00016 · Cited by 124 · see citing works
Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2
Singh, V. K., & Leu, S.-J. C. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90025-5 · Cited by 123 · see citing works
Effects of different types of stress and of “prokinetic” drugs on the control of the fasting motor complex in humans
Valori, R. M., Kumar, D., & Wingate, D. L. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90258-1 · Cited by 121 · see citing works
Activation of haemostasis by exercise, mental stress and adrenaline: effects on platelet sensitivity to thrombin and thrombin generation
Wallén, N. H., Goodall, A. H., Li, N., & Hjemdahl, P. (1999) · Clinical Science · doi:10.1042/cs0970027 · Cited by 120 · see citing works
Catecholamines Modulate Escherichia coli O157:H7 Adherence to Murine Cecal Mucosa
Chen, C., Brown, D. R., Xie, Y., Green, B. T., & Lyte, M. (2003) · Shock · doi:10.1097/01.shk.0000073867.66587.e0 · Cited by 118 · see citing works
A stress management programme for inflammatory bowel disease patients
Milne, B. J., Joachim, G., & Niedhardt, J. (1986) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.1986.tb01288.x · Cited by 118 · see citing works
Cholinergic nerves mediate stress-induced intestinal transport abnormalities in Wistar-Kyoto rats
Saunders, P. R., Hanssen, N. P. M., & Perdue, M. H. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.2.g486 · Cited by 118 · see citing works
Uncoupling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis in inflammatory bowel disease?
Straub, R. H., Herfarth, H., Falk, W., Andus, T., & Schölmerich, J. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00047-4 · Cited by 115 · see citing works
Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease
Straub, R. H., Vogl, D., Gross, V., Lang, B., Schölmerich, J., & Andus, T. (1998) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.00535.x · Cited by 114 · see citing works
The relation between daily stress and Crohn's disease
Garrett, V. D., Brantley, P. J., Jones, G. N., & McKnight, G. T. (1991) · Journal of Behavioral Medicine · doi:10.1007/bf00844770 · Cited by 112 · see citing works
Impact of oral contraceptive use on glucocorticoid sensitivity of pro-inflammatory cytokine production after psychosocial stress
Rohleder, N., Wolf, J. M., Piel, M., & Kirschbaum, C. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00019-7 · Cited by 112 · see citing works
Effect of psychological stress on salt and water transport in the human jejunum
Barclay, G. R., & Turnberg, L. A. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90319-2 · Cited by 109 · see citing works
Molecular mechanisms of corticosteroids in all_ergic diseases
Barnes, P. J. (2001) · Allergy · doi:10.1034/j.1398-9995.2001.00001.x · Cited by 108 · see citing works
Time kinetics of the endocrine response to acute psychological stress
Richter, S., Schürmeyer, T. H., Schedlowski, M., Hädicke, A., Tewes, U., Schmidt, R. E., & Wagner, T. O. F. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.5.8626864 · Cited by 107 · see citing works
Formation of Platelet-leukocyte Aggregates in Inflammatory Bowel Disease
Irving, P. M., Macey, M. G., Shah, U., Webb, L., Langmead, L., & Rampton, D. S. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200407000-00007 · Cited by 104 · see citing works
Self-citation
Review article: platelets in inflammatory bowel disease— pathogenetic role and therapeutic implications
COLLINS, C. E., & Rampton, D. S. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.153328000.x · Cited by 104 · see citing works
Self-citation
Colonic mucin release in response to immobilization stress is mast cell dependent
Castagliuolo, I., Wershil, B. K., Karalis, K. P., Pasha, A., Nikulásson, S. Þ., & Pothoulakis, C. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.6.g1094 · Cited by 102 · see citing works
Epinephrine inhibits endotoxin-induced IL-1β production: roles of tumor necrosis factor-α and IL-10
van der Poll, T., & Lowry, S. F. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.6.r1885 · Cited by 102 · see citing works
Long-term monitoring of psychosocial stress and symptomatology in inflammatory bowel disease
Greene, B. R., Blanchard, E. B., & Wan, C. K. (1994) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)90114-7 · Cited by 100 · see citing works
Neuromodulation of enteropathogen internalization in Peyer's patches from porcine jejunum
Green, B. T., Lyte, M., Kulkarni, A. P., & Brown, D. R. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00225-x · Cited by 98 · see citing works
Effect of Psychotherapy on the Course of Crohn's Disease: Results of the German Prospective Multicenter Psychotherapy Treatment Study on Crohn's Disease
Jantschek, G. (1998) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365529850172386 · Cited by 92 · see citing works
Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison with healthy controls
Schmid‐Ott, G., Jaeger, B., Meyera, B. S., et al. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.117800 · Cited by 91 · see citing works
The Measurement of Creativity by the Stroop Color and Word Test
Golden, C. J. (1975) · Journal of Personality Assessment · doi:10.1207/s15327752jpa3905_9 · Cited by 91 · see citing works
Stimulation of interleukin-6 production by corticotropin-releasing factor
Leu, S.-J. C., & Singh, V. K. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90018-k · Cited by 90 · see citing works
Genes, Microbes, and T Cells — New Therapeutic Targets in Crohn's Disease
Elson, C. O. (2002) · New England Journal of Medicine · doi:10.1056/nejm200202213460812 · Cited by 89 · see citing works
Academic Examinations Significantly Impact Immune Responses, but Not Lung Function, in Healthy and Well-Managed Asthmatic Adolescents
Kang, D.-H., Coe, C. L., & McCarthy, D. O. (1996) · Brain Behavior and Immunity · doi:10.1006/brbi.1996.0015 · Cited by 87 · see citing works
Psychological Stress and Inflammatory Bowel Disease: A Follow-up Study in Parents Who Lost a Child in Denmark
Li, J., Nørgård, B. M., Precht, D. H., & Olsen, J. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04155.x · Cited by 83 · see citing works
Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone
van der Poll, T., & Lowry, S. F. (1997) · Infection and Immunity · doi:10.1128/iai.65.6.2378-2381.1997 · Cited by 82 · see citing works
Corticotropin-releasing hormone antagonists possess anti-inflammatory effects in the mouse ileum
Wlk, M., Wang, C. C., Venihaki, M., Liu, J., Zhao, D., Anton, P. M., Mykoniatis, A., Pan, A., Zacks, J., Karalis, K. P., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.34783 · Cited by 79 · see citing works
Acute Stress Modulates the Histamine Content of Mast Cells in the Gastrointestinal Tract Through Interleukin‐1 and Corticotropin‐Releasing Factor Release in Rats
Eutamène, H., Théodorou, V., Fioramonti, J., & Bueno, L. P. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.052274 · Cited by 78 · see citing works
Effect of Substance P on Histamine Secretion from Gut Mucosa in Inflammatory Bowel Disease
Raithel, M. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750026236 · Cited by 77 · see citing works
Systemic lupus erythematosus and rheumatoid arthritis patients differ from healthy controls in their cytokine pattern after stress exposure
Jacobs, R., Pawlak, C. R., Mikeska, E., Meyer‐Olson, D., Martin, M., Heijnen, C. J., Schedlowski, M., & Schmidt, R. E. (2001) · Lara D. Veeken · doi:10.1093/rheumatology/40.8.868 · Cited by 75 · see citing works
“Natural History” of Crohn's Disease
Meyers, S., & Janowitz, H. D. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80085-2 · Cited by 73 · see citing works
Immune and Neuroendocrine Changes During Bereavement
Irwin, M. R., Daniels, M. L., & Weiner, H. (1987) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30554-9 · Cited by 73 · see citing works
Stability of Individual Differences in Cellular Immune Responses to Acute Psychological Stress
Marsland, A. L., Manuck, S. B., Fazzari, T. V., Stewart, C. J., & Rabin, B. S. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199505000-00012 · Cited by 72 · see citing works
Treatment of Ulcerative Colitis With Clonidine
Lechín, F., van der Dijs, B., Insausti, C. L., et al. (1985) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1985.tb02828.x · Cited by 71 · see citing works
Patients with Systemic Lupus Erythematosus Differ from Healthy Controls in Their Immunological Response to Acute Psychological Stress
Pawlak, C. R., Jacobs, R., Mikeska, E., et al. (1999) · Brain Behavior and Immunity · doi:10.1006/brbi.1999.0553 · Cited by 71 · see citing works
Large Bowel Disorders. I. Illness Configuration and Life Events
Fava, G. A., & Pavan, L. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000287001 · Cited by 69 · see citing works
Blood platelet responsivity to acute mental stress.
Malkoff, S. B., Muldoon, M. F., Zeigler, Z. R., & Manuck, S. B. (1993) · Psychosomatic Medicine · doi:10.1097/00006842-199311000-00001 · Cited by 67 · see citing works
Association of autonomic nervous hyperreflexia and systemic inflammation in patients with Crohn's disease and ulcerative colitis
Straub, R. H., Antoniou, E., Zeuner, M., Groß, V., Schölmerich, J., & Andus, T. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00150-1 · Cited by 67 · see citing works
Effects of elevated plasma noradrenaline concentration on the immune system in humans
Kappel, M., Poulsen, T. D., Galbo, H., & Pedersen, B. K. (1998) · European Journal of Applied Physiology · doi:10.1007/s004210050479 · Cited by 67 · see citing works
Evidence that Colitis Is Initiated by Environmental Stress and Sustained by Fecal Factors in the Cotton-Top Tamarin (Saguinus oedipus)
Wood, J. D., Peck, O. C., Tefend, K. S., Stonerook, M. J., Caniano, D. A., Mutabagani, K. H., Lhoták, Š., & Sharma, H. M. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005485215128 · Cited by 61 · see citing works
Environmental Stress Causes Mast Cell Degranulation, Endothelial and Epithelial Changes, and Edema in the Rat Intestinal Mucosa
WILSON, L. M., & BALDWIN, A. L. (1999) · Microcirculation · doi:10.1111/j.1549-8719.1999.tb00101.x · Cited by 57 · see citing works
Treatment of the mucosa with local anaesthetics in ulcerative colitis
Björck, S., Dahlström, A. B., Johansson, L., et al. (1992) · Inflammation Research · doi:10.1007/bf01996098 · Cited by 56 · see citing works
Targets of glucocorticoid action on TNF-α release by macrophages
Joyce, D. A., Gimblett, G., & Steer, J. H. (2001) · Inflammation Research · doi:10.1007/pl00012387 · Cited by 53 · see citing works
Relapse-Precipitating Life Events and Feelings in Patients with Inflammatory Bowel Disease
von Wietersheim, J., Köhler, T. C., & Feiereis, H. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000288617 · Cited by 53 · see citing works
Effect of cold-induced pain on salt and water transport in the human jejunum
Barclay, G. R., & Turnberg, L. A. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90558-6 · Cited by 52 · see citing works
Changes in plasma concentrations of interleukin-6 and interleukin-1 receptor antagonists in response to adrenaline infusion in humans
Søndergaard, S. R., Ostrowski, K., Ullum, H., & Pedersen, B. K. (2000) · European Journal of Applied Physiology · doi:10.1007/s004210000257 · Cited by 52 · see citing works
The influence of psychological stress and socioeconomic status on platelet activation in men
Steptoe, A., Magid, K. S., Edwards, S., Brydon, L., Hong, Y., & Erusalimsky, J. D. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(02)00453-7 · Cited by 52 · see citing works
Treatment of Distal Colitis with Local Anaesthetic Agents
Björck, S., Dahlström, A. B., & Ahlman, H. (2002) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2002.900401.x · Cited by 51 · see citing works
Local production of corticotropin releasing hormone is increased in experimental intestinal inflammation in rats.
van Tol, E. A., Petrusz, P., Lund, P. K., Yamauchi, M., & Sartor, R. B. (1996) · Gut · doi:10.1136/gut.39.3.385 · Cited by 51 · see citing works
Mortality following conjugal bereavement, Belgium 1991-96: The unexpected effect of education
Lusyne, P., Page, H., & Lievens, J. (2001) · Population studies · doi:10.1080/00324720127701 · Cited by 50 · see citing works
Adrenaline enhances LPS-induced IL-10 synthesis: evidence for protein kinase A-mediated pathway
Siegmund, B., Eigler, A., Hartmann, G., Hacker, U. T., & Endres, S. (1998) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(98)00014-9 · Cited by 48 · see citing works
NK1 receptor-mediated mechanisms regulate colonic hypersensitivity in the guinea pig
Meerveld, B. G., Gibson, M. S., Johnson, A. C., Venkova, K. M., & Sutkowski-Markmann, D. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00032-7 · Cited by 47 · see citing works
The effects of postnatal maternal separation on stress responsivity and experimentally induced colitis in adult rats
Milde, A. M., Enger, Ø., & Murison, R. C. C. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.01.002 · Cited by 46 · see citing works
Therapeutics and inflammatory bowel disease: A guide to the interpretation of randomized controlled trials
Feagan, B., McDonald, J. W. D., & Jj, K. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8536868 · Cited by 45 · see citing works
Relapsing ulcerative colitis associated with spinal cord stimulation
Kemler, M. A., Barendse, G. A. M., & van Kleef, M. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70570-6 · Cited by 45 · see citing works
Ulcerative Colitis-Like Lesion in Siamang Gibbons
Stout, C., & Snyder, R. L. (1969) · Gastroenterology · doi:10.1016/s0016-5085(19)33897-1 · Cited by 45 · see citing works
Stronger endocrine responses after brief psychological stress in women at familial risk of breast cancer
Gold, S. M., Zakowski, S. G., Valdimarsdottir, H. B., & Bovbjerg, D. H. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00046-x · Cited by 44 · see citing works
Genetic Origin of IBD
Hugot, J. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200402001-00003 · Cited by 44 · see citing works
Activation of haemostasis by exercise, mental stress and adrenaline: effects on platelet sensitivity to thrombin and thrombin generation
Wallén, N. H., Goodall, A. H., Li, N., et al. (1999) · Clinical Science · doi:10.1042/cs19990013 · Cited by 44 · see citing works
Familial and psychological risk factors of ulcerative colitis.
Tocchi, A., Lepre, L., Liotta, G., Mazzoni, G., Costa, G., Taborra, L., & Miccini, M. (1997) · PubMed · Cited by 43 · see citing works
Life Strain, Life Events, and Autonomic Response to a Psychological Stressor in Patients with Chronic Upper Abdominal Pain
Jørgensen, L. S., Bönlökke, L., & Christensen, N. J. (1986) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528609003107 · Cited by 40 · see citing works
Modulation of natural killer cell-mediated lysis by corticotropin-releasing neurohormone
Leu, S.-J. C., & Singh, V. K. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90113-l · Cited by 38 · see citing works
Immunity in Adolescents With Major Depression
Schleifer, S. J., Bartlett, J. A., Keller, S. E., Eckholdt, H., Shiflett, S. C., & Delaney, B. R. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200209000-00005 · Cited by 38 · see citing works
Cytokines and their receptors
Ray, A. K., & Sehgal, P. B. (1992) · Journal of the American Society of Nephrology · doi:10.1681/asn.v212s214 · Cited by 37 · see citing works
Platelet activation in mental stress
Næsh, O., Hædersdal, C., Hindberg, I., & Trap‐Jensen, J. (1993) · Clinical Physiology · doi:10.1111/j.1475-097x.1993.tb00330.x · Cited by 36 · see citing works
HYPNOTHERAPY IN IRRITABLE BOWEL SYNDROME
Whorwell, P. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91657-7 · Cited by 33 · see citing works
Divergent effects of corticotropin releasing hormone on endothelial cell nitric oxide synthase are associated with different expression of CRH type 1 and 2 receptors
Cantarella, G., Lempereur, L., Lombardo, G., Chiarenza, A., Pafumi, C., Zappalà, G., & Bernardini, R. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704322 · Cited by 33 · see citing works
Mental stress and physical exercise increase platelet-dependent thrombin generation
Kawano, T. A., Aoki, N., Hòmori, M., Kawano, K., Maki, A., Kimura, M., Yanagisawa, A., Ohsaki, T., Takahashi, R. M., Shiohara, T., et al. (2000) · Heart and Vessels · doi:10.1007/s003800070006 · Cited by 30 · see citing works
Brain-gut interactions in ulcerative colitis
Peck, O. C., & Wood, J. D. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70157-0 · Cited by 26 · see citing works
Age at onset of major depressive disorder predicts reductions in NK cell number and activity
Frank, M. G., Frank, J. L. W., Hendricks, S. E., Burke, W. J., & Johnson, D. R. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00395-0 · Cited by 26 · see citing works
Sensitization of rat alveolar macrophages to enhanced TNF-α release by in vivo treatment with dexamethasone
Renz, H., Henke, A., Hofmann, P., et al. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90242-h · Cited by 23 · see citing works
Depressive Symptoms Lead to Impaired Cellular Immune Response
Fortes, C., Farchi, S., Forastiere, F., Agabiti, N., Pacifici, R., Zuccaro, P., Perucci, C. A., & Ebrahim, S. B. J. (2003) · Psychotherapy and Psychosomatics · doi:10.1159/000071896 · Cited by 23 · see citing works
Psychological factors in ulcerative colitis in man and gibbon.
Gl, E. (1969) · PubMed · Cited by 23 · see citing works
Treatment of the mucosa with local anaesthetics in ulcerative colitis
Björck, S., Dahlström, A. B., Johansson, L., et al. (1992) · Inflammation Research · doi:10.1007/bf01991026 · Cited by 23 · see citing works
Effect of acute acoustic stress on anorectal function and sensation in healthy humans1
Gonlachanvit, S., Rhee, J., Sun, W. M., et al. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00592.x · Cited by 19 · see citing works
Acute emotional crises and ulcerative colitis
Brown, C. H. (1963) · Digestive Diseases and Sciences · doi:10.1007/bf02232035 · Cited by 16 · see citing works
[The correlation of psychosocial stress and disease activity in patients with Crohn disease and ulcerative colitis].
Paar, G. H., Bezzenberger, U., & Lorenz‐Meyer, H. (1988) · PubMed · Cited by 14 · see citing works
AN OBJECTIVE STUDY OF PSYCHOLOGICAL FACTORS IN ULCERATIVE COLITIS IN CHILDREN.
ALEXANDER, T. (1965) · PubMed · Cited by 8 · see citing works
Hypnotherapy in inflammatory bowel disease. A randomised, placebo-controlled trial
Forbes, A. (2012) · doi:10.1186/isrctn37515330 · Cited by 8 · see citing works
Maintaining Remissions Across the Lifespan
Lichtenstein, G. R., Cuffari, C., Kane, S. V., et al. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200407002-00003 · Cited by 7 · see citing works
[Life stress events preceding illness episodes in multiple sclerosis and ulcerative colitis--a comparison].
Bach, O., & Hj, W. (1990) · PubMed · Cited by 7 · see citing works
[Study on natural killer cell subset and activity in patients with depression].
Chu, L., Tian, S., Chen, H., et al. (2002) · PubMed · Cited by 5 · see citing works
Environmental Stress Causes Mast Cell Degranulation, Endothelial and Epithelial Changes, and Edema in the Rat Intestinal Mucosa
WILSON, L. M., & Baldwin, A. L. (1999) · Microcirculation · doi:10.1038/sj.mn.7300069 · Cited by 5 · see citing works

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Inflammatory bowel disease: cause and immunobiology
Baumgart, D. C., & Carding, S. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60750-8 · Cited by 2,147 · see citing works
Epidemiology and risk factors for IBD
Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741 · see citing works
Dysbiosis of the gut microbiota in disease
Carding, S., Verbeke, K., Vipond, D. T., Corfe, B. M., & Owen, L. J. (2015) · Microbial Ecology in Health & Disease · doi:10.3402/mehd.v26.26191 · Cited by 1,710 · see citing works
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · see citing works
Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders
Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works
Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management
Graff, L. A., Walker, J. R., & Bernstein, C. N. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20873 · Cited by 586 · see citing works
Neuropeptide, Y, peptide YY and pancreatic polypeptide in the gut-brain axis
Holzer, P., Reichmann, F., & Farzi, A. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.08.005 · Cited by 501 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response
Gao, X., Cao, Q., Cheng, Y., Zhao, D., Wang, Z., Yang, H., Wu, Q., You, L., Wang, Y., Lin, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720696115 · Cited by 400 · see citing works
A prospective population-based study of triggers of symptomatic flares in IBD
Bernstein, C. N., Singh, S., Graff, L. A., Walker, J. R., Miller, N., & Cheang, M. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.140 · Cited by 400 · see citing works
Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability
de Punder, K., & Pruimboom, L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00223 · Cited by 321 · see citing works
Pain and inflammatory bowel disease.
Bielefeldt, K., Davis, B., & Binion, D. G. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20848 · Cited by 304 · see citing works
Predicting relapse in Crohn’s disease: a biopsychosocial model
Bitton, A., Dobkin, P. L., Edwardes, M. D., Sewitch, M. J., Meddings, J. B., Rawal, S., Cohen, A., Vermeire, S., Dufresne, L., Franchimont, D., et al. (2008) · Gut · doi:10.1136/gut.2007.134817 · Cited by 254 · see citing works
Psychological issues in inflammatory bowel disease: an overview
Sajadinejad, M. S., Asgari, K., Molavi, H., Kalantari, M., & Adibi, P. (2012) · Gastroenterology Research and Practice · doi:10.1155/2012/106502 · Cited by 242 · see citing works
Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression
Frolkis, A. D., Vallerand, I. A., Shaheen, A.-A., Lowerison, M. W., Swain, M. G., Barnabe, C., Patten, S. B., & Kaplan, G. G. (2019) · Gut · doi:10.1136/gutjnl-2018-317182 · Cited by 228 · see citing works
Psychological adjustment and autonomic disturbances in inflammatory bowel diseases and irritable bowel syndrome
Pellissier, S., Dantzer, C., Canini, F., Mathieu, N., & Bonaz, B. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.10.004 · Cited by 198 · see citing works
Stress and the Brain-Gut Axis in Functional and Chronic-Inflammatory Gastrointestinal Diseases: A Transdisciplinary Challenge
Labanski, A., Langhorst, J., Engler, H., & Elsenbruch, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104501 · Cited by 200 · see citing works
Acceptance and Commitment Therapy Reduces Psychological Stress in Patients With Inflammatory Bowel Diseases
Wynne, B., McHugh, L., Gao, W., Keegan, D., Byrne, K., Rowan, C., Hartery, K., Kirschbaum, C., Doherty, G., Cullen, G., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.11.030 · Cited by 188 · see citing works
Psychological interventions for treatment of inflammatory bowel disease
Timmer, A., Preiss, J. C., Motschall, E., Rücker, G., Jantschek, G., & Moser, G. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006913.pub2 · Cited by 187 · see citing works
Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications
Ge, L., Liu, S., Li, S., Yang, J., Hu, G., Xu, C., & Song, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1016578 · Cited by 187 · see citing works
Do NSAIDs, Antibiotics, Infections, or Stress Trigger Flares in IBD?
Singh, S., Graff, L. A., & Bernstein, C. N. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.15 · Cited by 181 · see citing works
Stress triggers flare of inflammatory bowel disease in children and adults
Sun, Y., Li, L., Xie, R., Wang, B., Jiang, K., & Cao, H. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00432 · Cited by 171 · see citing works
Psychological Interventions for Irritable Bowel Syndrome and Inflammatory Bowel Diseases
Ballou, S., & Keefer, L. (2017) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.69 · Cited by 167 · see citing works
Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: A double-blind, placebo-controlled, randomized trial
Diop, L., Guillou, S., & Durand, H. (2008) · Nutrition Research · doi:10.1016/j.nutres.2007.10.001 · Cited by 162 · see citing works
The relationship among perceived stress, symptoms, and inflammation in persons with inflammatory bowel disease
Targownik, L. E., Sexton, K. A., Bernstein, M. T., Beatie, B., Sargent, M., Walker, J. R., & Graff, L. A. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2015.147 · Cited by 157 · see citing works
Association between depressive symptoms and incidence of Crohn's disease and ulcerative colitis: results from the Nurses' Health Study
Ananthakrishnan, A. N., Khalili, H., Pan, A., Higuchi, L. M., de Silva, P., Richter, J. M., Fuchs, C. S., & Chan, A. T. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.08.032 · Cited by 155 · see citing works
The Effect of Acute Psychologic Stress on Systemic and Rectal Mucosal Measures of Inflammation in Ulcerative Colitis
Mawdsley, J. E., Macey, M. G., Feakins, R. M., Langmead, L., & Rampton, D. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.017 · Cited by 143 · see citing works
Self-citation
Psychiatric co‐morbidity is associated with increased risk of surgery in Crohn's disease
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Reed-Knight, B., van Tilburg, M. A. L., Levy, R. L., Langer, S. L., Romano, J. M., Murphy, T. B., DuPen, M. M., & Feld, A. D. (2018) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsx082 · Cited by 30 · see citing works
Consensus statement on managing anxiety and depression in individuals with inflammatory bowel disease
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Kuroki, T., Ohta, A., Sherriff-Tadano, R., Matsuura, E., Takashima, T., Iwakiri, R., & Fujimoto, K. (2011) · Biological Research For Nursing · doi:10.1177/1099800410388638 · Cited by 28 · see citing works
The Stressometer: A Simple, Valid, and Responsive Measure of Psychological Stress in Inflammatory Bowel Disease Patients
Keegan, D., Byrne, K., Cullen, G., Doherty, G. A., Dooley, B., & Mulcahy, H. E. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv120 · Cited by 19 · see citing works
Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells
Shimba, A., Cui, G., Abe, S., Hirota, K., Miyauchi, E., Takami, D., Tani-ichi, S., Kato, R., Tajima, M., Kanahashi, T., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116093 · Cited by 15 · see citing works
Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice
Koh, S.-J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i28.8580 · Cited by 14 · see citing works
Functional disturbance of the stress-adaptation system in patients with scleroderma
Matsuura, E., Ohta, A., Suematsu, R., Inoue, H., Koarada, S., Tada, Y., Sherriff-Tadano, R., Kuroki, T., Ikeda, D., & Nagasawa, K. (2011) · Modern Rheumatology · doi:10.3109/s10165-010-0412-5 · Cited by 9 · see citing works
Evaluation of subcortical structure volumes in patients with non-specific digestive diseases
Skrobisz, K., Piotrowicz, G., Rudnik, A., Naumczyk, P., Sabisz, A., Markiet, K., & Szurowska, E. (2022) · Diagnostics · doi:10.3390/diagnostics12092199 · Cited by 4 · see citing works

Authors: Mawdsley, J. E., & Rampton, D. S.
Affiliations: Queen Mary University of London (GB)
Royal London Hospital (GB)
Corresponding author: Rampton, D S
ORCID: Mawdsley, J E
Venue: Gut
Publisher: BMJ
Published: 2005-09-14
Volume: 54
Issue: 10
Pages: 1481-1491
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.2005.064261
PMC: PMC1774724
OpenAlex: W1974161819
Cited by: 622
References: 155
Citations by year: 2026: 21 · 2025: 20 · 2024: 34 · 2023: 40 · 2022: 29 · 2021: 41 · 2020: 36 · 2019: 34 · 2018: 30 · 2017: 32 · 2016: 22 · 2015: 34 · 2014: 30 · 2013: 25 · 2012: 32
FWCI: 2.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: psychological stress, inflammatory bowel disease, psychoneuroimmunology, relapse, depression, life events, hypothalamic-pituitary-adrenal axis, gut microbiota, mucosal mast cells, corticotropin-releasing factor, animal models of colitis, gut mucosal immunity
MeSH terms: Acute Disease, Animals, Chronic Disease, Colitis, Ulcerative, Crohn Disease, Disease Models, Animal, Gastrointestinal Motility, Humans, Hypothalamo-Hypophyseal System, Intestinal Mucosa, Life Change Events, Pituitary-Adrenal System, Stress, Psychological, Inflammatory Bowel Diseases, Gastrointestinal Tract

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Psychological stress in IBD: new insights into pathogenic and therapeutic implications

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