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Cited by 97Developmental Biology and Gene RegulationBreast Lesions and CarcinomasGenomics and Chromatin Dynamics

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The Role of Tbx2 and Tbx3 in Mammary Development and Tumorigenesis

Rowley, Matthew, Grothey, Erin, Couch, Fergus J.·2004·Journal of Mammary Gland Biology and Neoplasia
DOI 10.1023/b:jomg.0000037156.64331.3f
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Abstract

TBX2 and TBX3 are members of a family of genes encoding developmental transcription factors, characterized by a 200 amino acid DNA binding domain (T-box). Tbx2 and Tbx3 are closely related T-box proteins that have been implicated in development of a number of different tissues including the mammary gland. TBX3 is required for normal mammary development in mouse models and in patients with ulnar-mammary syndrome (UMS). In addition to a role in development, TBX2 and TBX3 have been implicated in tumor development through downregulation of the alternative reading frame (ARF) tumor suppressor and an associated bypass of senescence. Here we review the current information on the roles of Tbx2 and Tbx3 in mammary gland development and tumorigenesis.

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Metadata

Authors
Rowley, M., Grothey, E., & Couch, F. J.
Affiliations
Mayo Clinic (US)
Corresponding author
Couch, Fergus J.
ORCID
Couch, Fergus J.
Venue
Journal of Mammary Gland Biology and Neoplasia
Publisher
Springer Science and Business Media LLC
Published
2004-04
Volume
9
Issue
2
Pages
109-118
ISSN
  • 1083-3021 (ISSN-L)
  • 1573-7039
DOI
10.1023/b:jomg.0000037156.64331.3f
OpenAlex
W2041399250
Cited by
97
References
69
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 7
FWCI
0.38
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Mammary Gland Biology and Neoplasia (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (CA 09441, CA87898, T32CA009441, R01CA087898)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
TBX2, TBX3, T-box transcription factor, mammary gland development, mammary carcinogenesis, ulnar-mammary syndrome, alternative reading frame, tumor suppressor, cellular senescence, mouse model
MeSH terms
Animals, Breast, Breast Neoplasms, Female, Humans, Mammary Glands, Animal, Signal Transduction, Mammary Neoplasms, Animal, Tumor Suppressor Protein p53, Receptors, Fibroblast Growth Factor, T-Box Domain Proteins, Tumor Suppressor Protein p14ARF, Receptor, Fibroblast Growth Factor, Type 2

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