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Cited by 273

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Identifying the patient at risk for post‐transplant lymphoproliferative disorder

Cockfield, S.M.·2001·Transplant Infectious Disease

Abstract

Abstract:Post‐transplant lymphoproliferative disorders (PTLD) are a recognized complication of the immunosuppression required to prevent allograft rejection, occurring in 1–20% of recipients of solid organ transplants. Several factors greatly increase the risk of developing PTLD early post‐transplant in any individual recipient. Epstein–Barr virus (EBV) infection is critical in the pathogenesis of the majority of these cases. Pre‐transplant EBV seronegativity increases the incidence of PTLD 10‐ to 75‐fold over that of EBV‐seropositive recipients. Other risk factors include very young recipient age, cytomegalovirus infection or mismatching (donor positive–recipient negative), aggressive immunosuppression with conventional biologic agents, and the type of organ transplanted. In contrast, the risk of developing PTLD late in the post‐transplant course does not appear to be influenced by the type of immunosuppressive agents employed, but rather by the duration of any immunosuppression. The role of EBV in late PTLD is also less certain, as a greater proportion of lesions are not associated with evidence of EBV infection. As the understanding of these risk factors has expanded, opportunities exist to target those populations at highest risk for the development of PTLD for aggressive monitoring and pre‐emptive or prophylactic therapy. It is hoped that implementation of such strategies will render early PTLD a preventable complication of transplantation.

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Crossref · 10.1034/j.1399-3062.2001.003002070.x

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Metadata

Authors
Cockfield, S. M.
Venue
Transplant Infectious Disease
Publisher
Wiley
Published
2001-06
Volume
3
Issue
2
Pages
70-78
ISSN
  • 1398-2273 (ISSN-L)
  • 1399-3062
OpenAlex
W2012103600
Cited by
273
References
22
FWCI
3.53
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Identifying the patient at risk for post‐transplant lymphoproliferative disorder. https://app.cochat.ai/papers/10.1034/j.1399-3062.2001.003002070.x
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Cockfield, S. M. (2001). Identifying the patient at risk for post‐transplant lymphoproliferative disorder. Transplant Infectious Disease. https://doi.org/10.1034/j.1399-3062.2001.003002070.x

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.