The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Identifying the patient at risk for post‐transplant lymphoproliferative disorder
Abstract
Abstract:Post‐transplant lymphoproliferative disorders (PTLD) are a recognized complication of the immunosuppression required to prevent allograft rejection, occurring in 1–20% of recipients of solid organ transplants. Several factors greatly increase the risk of developing PTLD early post‐transplant in any individual recipient. Epstein–Barr virus (EBV) infection is critical in the pathogenesis of the majority of these cases. Pre‐transplant EBV seronegativity increases the incidence of PTLD 10‐ to 75‐fold over that of EBV‐seropositive recipients. Other risk factors include very young recipient age, cytomegalovirus infection or mismatching (donor positive–recipient negative), aggressive immunosuppression with conventional biologic agents, and the type of organ transplanted. In contrast, the risk of developing PTLD late in the post‐transplant course does not appear to be influenced by the type of immunosuppressive agents employed, but rather by the duration of any immunosuppression. The role of EBV in late PTLD is also less certain, as a greater proportion of lesions are not associated with evidence of EBV infection. As the understanding of these risk factors has expanded, opportunities exist to target those populations at highest risk for the development of PTLD for aggressive monitoring and pre‐emptive or prophylactic therapy. It is hoped that implementation of such strategies will render early PTLD a preventable complication of transplantation.
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Cites
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Cited by
Spectrum of cancer risk among US solid organ transplant recipients
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Metadata
- Authors
- Cockfield, S. M.
- Venue
- Transplant Infectious Disease
- Publisher
- Wiley
- Published
- 2001-06
- Volume
- 3
- Issue
- 2
- Pages
- 70-78
- ISSN
- 1398-2273 (ISSN-L)
- 1399-3062
- OpenAlex
- W2012103600
- Cited by
- 273
- References
- 22
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cockfield, S. M. (2001). Identifying the patient at risk for post‐transplant lymphoproliferative disorder. Transplant Infectious Disease. https://doi.org/10.1034/j.1399-3062.2001.003002070.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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