The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Secondary Cancers after Bone Marrow Transplantation for Leukemia or Aplastic Anemia
Abstract
To determine the incidence of secondary cancers after bone marrow transplantation, we reviewed the records of all patients at our center who received allogeneic, syngeneic, or autologous transplants for leukemia (n = 1926) or aplastic anemia (n = 320). Thirty-five patients were given a diagnosis of secondary cancer between 1.5 months and 13.9 years (median, 1.0 year) after transplantation. Sixteen patients had non-Hodgkin's lymphomas, 6 had leukemias, and 13 had solid tumors (including 3 each with glioblastoma, melanoma, and squamous-cell carcinoma). There were 1.2 secondary cancers per 100 exposure-years during the first year after transplantation (95 percent confidence interval, 0.7 to 2.0). The rate declined to 0.4 (95 percent confidence interval, 0.2 to 0.7) after one year. The age-adjusted incidence of secondary cancer was 6.69 times higher than that of primary cancer in the general population. In a multivariate model, the predictors (and relative risks) of any type of secondary cancer were acute graft-versus-host disease treated with either antithymocyte globulin (relative risk, 4.2) or an anti-CD3 monoclonal antibody (13.6) and total-body irradiation (3.9). Two additional factors were associated with secondary non-Hodgkin's lymphomas: T-lymphocyte depletion of donor marrow (12.4) and HLA mismatch (3.8). We conclude that recipients of bone marrow transplantation have a low but significant risk of a secondary cancer, particularly non-Hodgkin's lymphoma.
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Cites
The Statistical Analysis of Failure Time Data.
Aitkin, M., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,877
Chronic graft-versus-host syndrome in man
Shulman, H. M., Sullivan, K. M., Weiden, P. L., McDonald, G. B., Striker, G. E., Sale, G. E., Hackman, R., Tsoi, M.-S., Storb, R., & Donnall Thomas, E. (1980) · The American Journal of Medicine · doi:10.1016/0002-9343(80)90380-0 · Cited by 2,406
Self-citationBone-Marrow Transplantation: (First of Two Parts)
Thomas, E. D., Storb, R., Clift, R. A., Fefer, A., Johnson, F. L., Neiman, P. E., Lerner, K. G., Glucksberg, H., & Buckner, C. D. (1975) · New England Journal of Medicine · doi:10.1056/nejm197504172921605 · Cited by 1,693
Self-citationStorb, R., Deeg, H. J., Whitehead, J., Appelbaum, F., Beatty, P., Bensinger, W., Buckner, C. D., Clift, R., Doney, K., Farewell, V., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198603203141201 · Cited by 1,411
Self-citationSantos, G. W., Tutschka, P. J., Brookmeyer, R., Saral, R., Beschorner, W. E., Bias, W. B., Braine, H. G., Burns, W. H., Elfenbein, G. J., Kaizer, H., et al. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312013092202 · Cited by 809
Bone Sarcomas Linked to Radiotherapy and Chemotherapy in Children
Tucker, M. A., D'Angio, G. J., Boice, J. D., Strong, L. C., Li, F. P., Stovall, M., Stone, B. J., Green, D. M., Lombardi, F., Newton, W., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198709033171002 · Cited by 765
Risk of Second Cancers after Treatment for Hodgkin's Disease
Tucker, M. A., Coleman, C. N., Cox, R. S., Varghese, A., & Rosenberg, S. A. (1988) · New England Journal of Medicine · doi:10.1056/nejm198801143180203 · Cited by 718
Incidence of second primary tumours among childhood cancer survivors
Hawkins, M., Draper, G., & Kingston, J. (1987) · British Journal of Cancer · doi:10.1038/bjc.1987.200 · Cited by 332
Thomas, E. D., Clift, R. A., Hersman, J., Sanders, J. E., Stewart, P., Buckner, C. D., Fefer, A., McGuffin, R., Smith, J. W., & Storb, R. (1982) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(82)90083-9 · Cited by 271
Self-citationSuppression of in vitro Epstein-Barr virus infection. A new role for adult human T lymphocytes.
Thorley-Lawson, D. A., Chess, L., & Strominger, J. L. (1977) · The Journal of experimental medicine · doi:10.1084/jem.146.2.495 · Cited by 206
Cited by
Solid Cancers after Bone Marrow Transplantation
Curtis, R. E., Rowlings, P. A., Deeg, H. J., Shriner, D. A., Socié, G., Travis, L. B., Horowitz, M. M., Witherspoon, R. P., Hoover, R. N., Sobocinski, K. A., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703273361301 · Cited by 965
Self-citation
Metadata
- Authors
- Witherspoon, R. P., Fisher, L. D., Schoch, G., Martin, P., Sullivan, K. M., Sanders, J., Deeg, H. J., Doney, K., Thomas, D., Storb, R., & Thomas, E. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1989-09-21
- Volume
- 321
- Issue
- 12
- Pages
- 784-789
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2342320434
- Cited by
- 409
- References
- 16
- FWCI
- 14.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Witherspoon, R. P., Fisher, L. D., Schoch, G., Martin, P., Sullivan, K. M., Sanders, J., Deeg, H. J., Doney, K., Thomas, D., Storb, R., & Thomas, E. D. (1989). Secondary Cancers after Bone Marrow Transplantation for Leukemia or Aplastic Anemia. New England Journal of Medicine. https://doi.org/10.1056/nejm198909213211203
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