The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Pathophysiology of pruritus in atopic dermatitis: an overview
Abstract
Abstract: Pruritus is an essential feature of atopic dermatitis (AD) and the diagnosis of active AD cannot be made without the history of itching. Because of the high impact on life quality, most of the patients measure the severity of eczema by the intensity of pruritus rather than appearance of skin lesions. However, although pruritus is a cardinal symptom of AD, its mechanism and association with the cutaneous nervous system is not completely understood. Recently, a considerable progress has been achieved in clarifying the complex pathophysiology of pruritus in AD. As a cutaneous sensory perception, itch requires excitation of neuropeptide‐containing free nerve endings of unmyelinated nociceptor fibers. It is well known that histamine and acetylcholine provoke itch by direct binding to ‘itch receptors’ and several mediators such as neuropeptides, proteases or cytokines indirectly via histamine release. Interestingly, some variations of these complex mechanisms could be demonstrated in patients with AD. This review highlights the recent knowledge of different mechanisms which may be involved in regulating pruritus in patients with AD potentially leading to new therapeutic applications for the treatment of itch in AD.
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Citations
Cites
Neuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727
Bergasa, N. V., Alling, D. W., Talbot, T. L., Swain, M. G., Yurdaydin, C., Turner, M. L., Schmitt, J. M., Walker, E. C., & Jones, E. A. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-3-199508010-00001 · Cited by 365
Increased number of immunoreactive nerve fibers in atopic dermatitis
Tobin, D., Nabarro, G., de la Faute, H. B., van Vloten, W. A., van der Putte, S. C. J., & Schuurman, H.-J. (1992) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(92)90134-n · Cited by 211
Neuropeptides in skin from patients with atopic dermatitis: an immunohistochemical study
PINCELLI, C., FANTINI, F., MASSIMI, P., GIROLOMONI, G., SEIDENARI, S., & GIANNETTI, A. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb06261.x · Cited by 153
Cited by
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
Dillon, S. R., Sprecher, C., Hammond, A., Bilsborough, J., Rosenfeld-Franklin, M., Presnell, S. R., Haugen, H. S., Maurer, M., Harder, B., Johnston, J., et al. (2004) · Nature Immunology · doi:10.1038/ni1084 · Cited by 1,015
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 665
Self-citationFrontiers in pruritus research: scratching the brain for more effective itch therapy
Paus, R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28553 · Cited by 373
Environmental risk factors and their role in the management of atopic dermatitis
Kantor, R., & Silverberg, J. I. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1212660 · Cited by 365
Correlation of IL-31 serum levels with severity of atopic dermatitis
Raap, U., Wichmann, K., Bruder, M., Ständer, S., Wedi, B., Kapp, A., & Werfel, T. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.05.047 · Cited by 299
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Metadata
- Authors
- Ständer, S., & Steinhoff, M.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 2002-02
- Volume
- 11
- Issue
- 1
- Pages
- 12-24
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W1966170746
- Cited by
- 252
- References
- 4
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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