The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Rho Proteins: Linking Signaling with Membrane Trafficking
Open accessAbstract
Rho proteins are well known for their effects on the actin cytoskeleton, and are activated in response to a variety of extracellular stimuli. Several Rho family members are localized to vesicular compartments, and increasing evidence suggests that they play important roles in the trafficking of vesicles on both endocytic and exocytic pathways. In particular, RhoA, RhoB, RhoD, Rac and Cdc42 have been shown to affect various steps of membrane trafficking. The underlying molecular basis for these effects of Rho proteins are incompletely understood, but in the case of Cdc42 it appears that it can drive vesicle movement through Arp2/3 complex‐mediated actin polymerization at the surface of the vesicle. This is similar to what is believed to happen when Rac and Cdc42 stimulate actin polymerization at the plasma membrane. Rho proteins may also affect membrane trafficking by altering phosphatidylinositide composition of membrane compartments, or through interactions with microtubules.
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Cites
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
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Self-citationMechanisms of phagocytosis in macrophages
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Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells
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“So far, there is no evidence that Rac/Cdc42 are also involved in driving the movement of the phagosome away from the plasma membrane, although interestingly phosphatidylinositide 3-kinase (PI 3-K) appears to act at a later step to regulate internalization but not actin polymerization (22,24).”
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Differential Localization of Rho Gtpases in Live Cells
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Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes
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IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
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The role of ARF and Rab GTPases in membrane transport
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Cited by
Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Luo, L. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.031802.150501 · Cited by 658
Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes
Watson, R. T., Kanzaki, M., & Pessin, J. E. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0011 · Cited by 448
Vaezi, A., Bauer, C., Vasioukhin, V., & Fuchs, E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00259-9 · Cited by 349
Sweeney, G. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(02)00006-2 · Cited by 271
The role of Rho GTPases in disease development
Boettner, B., & Van Aelst, L. (2002) · Gene · doi:10.1016/s0378-1119(02)00426-2 · Cited by 229
Metadata
- Authors
- Ridley, A. J.
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2001-05
- Volume
- 2
- Issue
- 5
- Pages
- 303-310
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W1597663953
- Cited by
- 275
- References
- 80
- FWCI
- 10.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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