Leptin signalling

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326 · see citing works

Signal transduction by the JNK group of MAP kinases

Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works

STATs and Gene Regulation

Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979 · see citing works

Identification and expression cloning of a leptin receptor, OB-R.

Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496 · see citing works

Obesity and insulin resistance

Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,283 · see citing works

Abnormal splicing of the leptin receptor in diabetic mice

Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327 · see citing works

The p38 signal transduction pathway Activation and function

Ono, K., & Han, J. (2000) · Cellular Signalling · doi:10.1016/s0898-6568(99)00071-6 · Cited by 1,571 · see citing works

Leptin

Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428 · see citing works

The Leptin Receptor

Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289 · see citing works

The role of STATs in transcriptional control and their impact on cellular function

Bromberg, J., & Darnell, J. E. (2000) · Oncogene · doi:10.1038/sj.onc.1203476 · Cited by 1,201 · see citing works

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80062-3 · Cited by 1,014 · see citing works

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

Chan, T. O., Rittenhouse-Simmons, S., & Tsichlis, P. N. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.965 · Cited by 981 · see citing works

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E., & Yancopoulos, G. D. (1995) · Science · doi:10.1126/science.7871433 · Cited by 979 · see citing works

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

SHEPHERD, P. R., WITHERS, D. J., & SIDDLE, K. (1998) · Biochemical Journal · doi:10.1042/bj3330471 · Cited by 953 · see citing works

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

Bjørbæk, C., Uotani, S., da Silva, B., & Flier, J. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32686 · Cited by 890 · see citing works

Serine phosphorylation of STATs

Decker, T., & Kovarik, P. (2000) · Oncogene · doi:10.1038/sj.onc.1203481 · Cited by 887 · see citing works

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

Vanhaesebroeck, B., & Waterfield, M. D. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4701 · Cited by 851 · see citing works

Leptin receptor missense mutation in the fatty Zucker rat

Phillips, M. S., Liu, Q., Hammond, H. A., Dugan, V., Hey, P. J., Caskey, C. T., & Hess, J. F. (1996) · Nature Genetics · doi:10.1038/ng0596-18 · Cited by 822 · see citing works

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

Baumann, H., Morella, K. K., White, D. W., Dembski, M., Bailon, P., Kim, H., Lai, C. F., & Tartaglia, L. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8374 · Cited by 810 · see citing works

Activation of Downstream Signals by the Long Form of the Leptin Receptor

Banks, A. S., Davis, S. M., Bates, S. H., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14563 · Cited by 797 · see citing works

Defective STAT signaling by the leptin receptor in diabetic mice.

Ghilardi, N., Ziegler, S., Wiestner, A. C., Stoffel, R., Heim, M. H., & Skoda, R. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6231 · Cited by 793 · see citing works

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7001 · Cited by 766 · see citing works

Protein tyrosine phosphatases in signal transduction

Neel, B. G., & Tonks, N. K. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80063-4 · Cited by 757 · see citing works

Protein kinase C isozymes and the regulation of diverse cell responses

Dempsey, E. C., Newton, A. C., Mochly‐Rosen, D., Fields, A. P., Reyland, M. E., Insel, P. A., & Messing, R. O. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.3.l429 · Cited by 738 · see citing works

Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

Soderling, S. H., & Beavo, J. A. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00073-3 · Cited by 737 · see citing works

Modulation of Insulin Activities by Leptin

Cohen, B., Novick, D., & Rubinstein, M. (1996) · Science · doi:10.1126/science.274.5290.1185 · Cited by 716 · see citing works

Leptin induces oxidative stress in human endothelial cells

Bouloumié, A., Marumo, T., Lafontan, M., & Busse, R. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.10.1231 · Cited by 679 · see citing works

Crystal structure of the obese protein Ieptin-E100

Zhang, F. P. Y., Basinski, M. B., Beals, J. M., Briggs, S., Churgay, L. M., Clawson, D. K., DiMarchi, R. D., Furman, T. C., Hale, J. E., Hsiung, H. M., et al. (1997) · Nature · doi:10.1038/387206a0 · Cited by 669 · see citing works

The role of SOCS-3 in leptin signaling and leptin resistance

Bjørbæk, C., El-Haschimi, K., Frantz, J. D., & Flier, J. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30059 · Cited by 639 · see citing works

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

Zhang, J., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., Moritz, R. L., Cary, D., Richardson, R. T., Hausmann, G., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2071 · Cited by 626 · see citing works

Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A

Yamagishi, S., Edelstein, D., Du, X.-L., Kaneda, Y., Guzmán, M., & Brownlee, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007383200 · Cited by 620 · see citing works

Novel Effects of Nitric Oxide

Davis, K. L., Martin, E., Turko, I. V., & Murad, F. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.203 · Cited by 585 · see citing works

SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985

Bjørbæk, C., Lavery, H. J., Bates, S. H., Olson, R. K., Davis, S. M., Flier, J. S., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007577200 · Cited by 537 · see citing works

SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling

Emanuelli, B., Peraldi, P., Filloux, C., Sawka‐Verhelle, D., Hilton, D. J., & OBBERGHEN, E. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.15985 · Cited by 468 · see citing works

SOCS: physiological suppressors of cytokine signaling

Krebs, D. L., & Hilton, D. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.16.2813 · Cited by 463 · see citing works

Human leptin: from an adipocyte hormone to an endocrine mediator

Wauters, M., Considine, R. V., & Gaal, L. V. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430293 · Cited by 458 · see citing works

Tailoring cAMP-signalling responses through isoform multiplicity

Houslay, M. D. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01050-5 · Cited by 448 · see citing works

Intracerebroventricular Leptin Increases Lumbar and Renal Sympathetic Nerve Activity and Blood Pressure in Normal Rats

Dunbar, J. C., Hu, Y., & Lu, H. (1997) · Diabetes · doi:10.2337/diab.46.12.2040 · Cited by 414 · see citing works

Direct effects of leptin on brown and white adipose tissue.

Siegrist-Kaiser, C. A., Pauli, V., Juge-Aubry, C. E., Boss, O., Pernin, A., Chin, W. W., Cusin, I., Rohner‐Jeanrenaud, F., Burger, A. G., Zapf, J., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119834 · Cited by 366 · see citing works

Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors

Bjørbæk, C., Buchholz, R. M., Davis, S. M., Bates, S. H., Pierroz, D. D., Gu, H., Neel, B. G., Myers, M. G., & Flier, J. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007439200 · Cited by 364 · see citing works

Expression of Leptin Receptor Isoforms in Rat Brain Microvessels

Bjørbæk, C., Elmquist, J. K., Michl, P., Ahima, R. S., Bueren, A. M. V., McCall, A. L., & Flier, J. S. (1998) · Endocrinology · doi:10.1210/endo.139.8.6154 · Cited by 340 · see citing works

Leptin induces direct vasodilation through distinct endothelial mechanisms.

Lembo, G., Vecchione, C., Fratta, L., Marino, G., Trimarco, V., d’Amati, G., & Trimarco, B. (2000) · Diabetes · doi:10.2337/diabetes.49.2.293 · Cited by 329 · see citing works

Model for the regulation of energy balance and adiposity by the central nervous system

Schwartz, M. W., Baskin, D. G., Kaiyala, K. J., & Woods, S. C. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.4.584 · Cited by 323 · see citing works

Pivotal role of nitric oxide in the control of blood pressure after leptin administration.

Frühbeck, G. (1999) · Diabetes · doi:10.2337/diabetes.48.4.903 · Cited by 319 · see citing works

Leptin in reproduction

Caprio, M., Fabbrini, E., Isidori, A. M., Aversa, A., & Fabbri, A. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00352-0 · Cited by 308 · see citing works

Leptin Receptor (OB-R) Signaling

White, D. W., Kuropatwinski, K. K., Devos, R., Baumann, H., & Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4065 · Cited by 293 · see citing works

Rho Proteins: Linking Signaling with Membrane Trafficking

Ridley, A. J. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.002005303.x · Cited by 274 · see citing works

Modulation of Circulating Leptin Levels by Its Soluble Receptor

Huang, L., Wang, Z., & Cai, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009795200 · Cited by 263 · see citing works

Leptin: physiology and pathophysiology

Frühbeck, G., Jebb, S. A., & Prentice, A. M. (1998) · Clinical Physiology · doi:10.1046/j.1365-2281.1998.00129.x · Cited by 254 · see citing works

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.

Uotani, S., Bjørbæk, C., Tornøe, J., & Flier, J. S. (1999) · Diabetes · doi:10.2337/diabetes.48.2.279 · Cited by 253 · see citing works

In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin

Kim, Y., Uotani, S., Pierroz, D. D., Flier, J. S., & Kahn, B. B. (2000) · Endocrinology · doi:10.1210/endo.141.7.7536 · Cited by 245 · see citing works

Rho family proteins in cell adhesion and cell migration

Evers, E. E., Zondag, G. C. M., Malliri, A., Price, L., ten Klooster, J. P., van der Kammen, R. A., & Collard, J. G. (2000) · European Journal of Cancer · doi:10.1016/s0959-8049(00)00091-5 · Cited by 241 · see citing works

Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes

Zhao, A. Z., Shinohara, M. M., Huang, D., Shimizu, M., Eldar-Finkelman, H., Krebs, E. G., Beavo, J. A., & Bornfeldt, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11348 · Cited by 238 · see citing works

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

Zhao, A. Z., Bornfeldt, K., & Beavo, J. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3920 · Cited by 236 · see citing works

Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3‐kinase‐, Rho‐, and Rac‐dependent signaling pathways

Attoub, S., Noë, V., Pirola, L., Bruyneel, E. A., Chastre, E., Mareel, M., Wymann, M. P., & Gespach, C. P. (2000) · The FASEB Journal · doi:10.1096/fj.00-0162 · Cited by 235 · see citing works

Leptin Action in Intestinal Cells

Morton, N. M., Emilsson, V., Liu, Y.-L., & Cawthorne, M. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.26194 · Cited by 227 · see citing works

Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat

Takaya, K., Ogawa, Y., Hiraoka, J., Hosoda, K., Yamori, Y., Nakao, K., & Koletsky, R. J. (1996) · Nature Genetics · doi:10.1038/ng1096-130 · Cited by 207 · see citing works

Leptin stimulates glucose transport and glycogen synthesis in C 2 C 12 myotubes: evidence for a PI3-kinase mediated effect

Berti, L., Kellerer, M., Capp, E., & H�ring, H. U. (1997) · Diabetologia · doi:10.1007/s001250050722 · Cited by 204 · see citing works

A Short Form of Leptin Receptor Performs Signal Transduction

Murakami, T., Yamashita, T., Iida, M., Kuwajima, M., & Shima, K. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.6030 · Cited by 203 · see citing works

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

Kellerer, M., Koch, M., Metzinger, E., Mushack, J., Capp, E., & Häring, H. (1997) · Diabetologia · doi:10.1007/s001250050832 · Cited by 198 · see citing works

Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

Szántó, I., & Kahn, C. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050580497 · Cited by 188 · see citing works

Leptin Attenuates Cardiac Contraction in Rat Ventricular Myocytes

Nickola, M. W., Wold, L. E., Colligan, P. B., Wang, G., Samson, W. K., & Ren, J. T. (2000) · Hypertension · doi:10.1161/01.hyp.36.4.501 · Cited by 184 · see citing works

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

Li, C., & Friedman, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9677 · Cited by 177 · see citing works

Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis

Calapai, G., Corica, F., Corsonello, A., Sautebin, L., Rosa, M. D., Campo, G. M., Buemi, M., Mauro, V. N., & Caputi, A. P. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5867 · Cited by 176 · see citing works

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Carpenter, L. R., Farruggella, T. J., Symes, A. J., Karow, M. L., Yancopoulos, G. D., & Stahl, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6061 · Cited by 175 · see citing works

Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding

Devos, R., Guisez, Y., der Heyden, J. V., White, D. W., Kalai, M., Fountoulakis, M., & Plaetinck, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18304 · Cited by 163 · see citing works

Involvement of Nitric Oxide in Endothelium-Dependent Arterial Relaxation by Leptin

Kimura, K., Tsuda, K., Baba, A., Kawabe, T., Boh-oka, S.-I., Ibata, M., Moriwaki, C., Hano, T., & Nishio, I. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3005 · Cited by 159 · see citing works

Localization of Leptin Binding Domain in the Leptin Receptor

Fong, T. M., Huang, R. R., Tota, M. R., Mao, C., Smith, T., Varnerin, J., Karpitskiy, V. V., Krause, J. E., & der Ploeg, L. H. T. V. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.2.234 · Cited by 151 · see citing works

Transgenic Complementation of Leptin-Receptor Deficiency

Kowalski, T. J., Liu, S.-M., Leibel, R. L., & Chua, S. C. (2001) · Diabetes · doi:10.2337/diabetes.50.2.425 · Cited by 150 · see citing works

Subcellular Localization and Internalization of the Four Human Leptin Receptor Isoforms

Barr, V. A., Lane, K., & Taylor, S. I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21416 · Cited by 144 · see citing works

Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor

Eyckerman, S., Broekaert, D., Verhee, A., Vandekerckhove, J. S., & Tavernier, J. H. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02205-5 · Cited by 142 · see citing works

Essential Role of Phosphoinositide 3-Kinase in Leptin-inducedK ATP Channel Activation in the Rat CRI-G1 Insulinoma Cell Line

Harvey, J., McKay, N. G., Walker, K. S., KAAY, J. V. D., Downes, C. P., & Ashford, M. L. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4660 · Cited by 136 · see citing works

Physiological Increase in Plasma Leptin Markedly Inhibits Insulin Secretion In Vivo

Cases, J. A., Gabriely, I., Xiao, H., Yang, X. M., Michaeli, T., Fleischer, N., Rossetti, L., & Barzilai, N. (2001) · Diabetes · doi:10.2337/diabetes.50.2.348 · Cited by 128 · see citing works

Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lepob ) mice

Winters, B. D., Mo, Z., Brooks-Asplund, E. M., Kim, S., Shoukas, A. A., Li, D., Nyhan, D. P., & Berkowitz, D. E. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.6.2382 · Cited by 128 · see citing works

Leptin receptor isoforms expressed in human adipose tissue

Kielar, D., Clark, J. S. C., Ciechanowicz, A., Kurzawski, G., Sulikowski, T., & Naruszewicz, M. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90124-x · Cited by 116 · see citing works

Inhibition of NO Synthesis Enhances Chronic Cardiovascular and Renal Actions of Leptin

Kuo, J. J., Jones, O. B., & Hall, J. E. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.670 · Cited by 114 · see citing works

High Leptin Levels Acutely Inhibit Insulin-Stimulated Glucose Uptake without Affecting Glucose Transporter 4 Translocation in L6 Rat Skeletal Muscle Cells

Sweeney, G., Keen, J., Somwar, R., Konrad, D., Garg, R. R., & Klip, A. (2001) · Endocrinology · doi:10.1210/endo.142.11.8496 · Cited by 106 · see citing works

Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding

Morley, J. E., Alshaher, M., Farr, S. A., Flood, J. F., & Kumar, V. B. (1999) · Peptides · doi:10.1016/s0196-9781(99)00012-1 · Cited by 105 · see citing works

Insulin and Leptin Acutely Regulate Cholesterol Ester Metabolism in Macrophages by Novel Signaling Pathways

O’Rourke, L., Yeaman, S., & Shepherd, P. R. (2001) · Diabetes · doi:10.2337/diabetes.50.5.955 · Cited by 99 · see citing works

Leptin and OB-R: Body weight regulation by a cytokine receptor

White, D. W., & Tartaglia, L. A. (1996) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(96)00040-8 · Cited by 97 · see citing works

Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues

Emilsson, V., Arch, J. R. S., de Groot, R. P., Lister, C. A., & Cawthorne, M. A. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00874-1 · Cited by 97 · see citing works

Effects of Leptin on Insulin Secretion From Isolated Rat Pancreatic Islets

Ookuma, M., Ookuma, K., & York, D. A. (1998) · Diabetes · doi:10.2337/diab.47.2.219 · Cited by 91 · see citing works

CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells

Suzuki, R., Sakamoto, H., Yasukawa, H., Masuhara, M., Wakioka, T., Sasaki, A. T., Yuge, K., Komiya, S., Inoue, A., & Yoshimura, A. (1998) · Oncogene · doi:10.1038/sj.onc.1202143 · Cited by 88 · see citing works

Leptin Resistance of Adipocytes in Obesity: Role of Suppressors of Cytokine Signaling

Wang, Z., Zhou, Y.-T., Kakuma, T., Lee, Y., Kalra, S. P., Kalra, P. S., Pan, W., & Unger, R. H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3615 · Cited by 87 · see citing works

Leptin receptor (OB‐R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130

Nakashima, K., Narazaki, M., & Taga, T. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00013-6 · Cited by 83 · see citing works

Leptin and its role in lipid metabolism

Hynes, G. R., & Jones, P. J. H. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200106000-00012 · Cited by 79 · see citing works

Role of leptin in ulcer healing

Konturek, P. C., Brzozowski, T., Šuleková, Z., Brzozowska, I. M., Duda‐Chodak, A., Meixner, H., Hahn, E. G., & Konturek, S. J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00748-8 · Cited by 76 · see citing works

Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice.

Chen, N. G., Swick, A. G., & Romsos, D. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119629 · Cited by 76 · see citing works

Free and protein bound leptin are distinct and independently controlled factors in energy regulation

Brabant, G. E., Horn, R., Mühlen, A. V. Z., Mayr, B. M., Wurster, U., Heidenreich, F., Schnabel, D., Grüters‐Kieslich, A., Zimmermann‐Belsing, T., & Feldt‐Rasmussen, U. (2000) · Diabetologia · doi:10.1007/s001250051326 · Cited by 75 · see citing works

Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2

Berti, L., & Gammeltoft, S. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00154-9 · Cited by 75 · see citing works

Do Leptin Receptors Play a Functional Role in the Endocrine Pancreas?

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Leptin activation of ATP‐sensitive K+ (KATP) channels in rat CRI‐G1 insulinoma cells involves disruption of the actin cytoskeleton

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Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli

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Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE 2 , IL-6, and IL-8 Production

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PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

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Apoptotic Pathways Are Inhibited by Leptin Receptor Activation in Neutrophils

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Immunological functions of leptin and adiponectin

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Leptin and its role in hippocampal synaptic plasticity

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The multifactorial role of leptin in driving the breast cancer microenvironment

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Nonclassic Endogenous Novel Regulators of Angiogenesis

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Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATPchannel activation

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Role of Leptin in Cardiovascular Diseases

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Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses

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Leptin and its metabolic interactions – an update

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Antiapoptotic Effects of Leptin in Human Neuroblastoma Cells

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Leptin‐mediated cytokine release and migration of eosinophils: Implications for immunopathophysiology of allergic inflammation

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Notch, IL-1 and Leptin Crosstalk Outcome (NILCO) Is Critical for Leptin-Induced Proliferation, Migration and VEGF/VEGFR-2 Expression in Breast Cancer

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Leptin Interferes with the Effects of the Antiestrogen ICI 182,780 in MCF-7 Breast Cancer Cells

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Adipokines as regulators of muscle metabolism and insulin sensitivityThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

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Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal‐transduction pathways

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Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers

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Circulating Leptin Correlates with Left Ventricular Mass in Morbid (Grade III) Obesity before and after Weight Loss Induced by Bariatric Surgery: A Potential Role for Leptin in Mediating Human Left Ventricular Hypertrophy

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The Interplay between Obesity and Inflammation

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Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer’s Disease

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Does leptin play a cytokine-like role within the airways of COPD patients?

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Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity

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Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation

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Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis

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Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc ( Min/+ ) colon epithelial cell line

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Role of Adipokines Signaling in the Modulation of T Cells Function

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Leptin Increases Cardiomyocyte Hyperplasia via Extracellular Signal-Regulated Kinase- and Phosphatidylinositol 3-Kinase-Dependent Signaling Pathways

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Hepatic leptin signaling in obesity

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Leptin regulation of proangiogenic molecules in benign and cancerous endometrial cells

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Leptin Increases Axonal Growth Cone Size in Developing Mouse Cortical Neurons by Convergent Signals Inactivating Glycogen Synthase Kinase-3β

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Lean heart: Role of leptin in cardiac hypertrophy and metabolism

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Leptin and Adiponectin: new players in the field of tumor cell and leukocyte migration

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Leptin phase-advances the rat suprachiasmatic circadian clock in vitro

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The Multifaceted Mechanism of Leptin Signaling within Tumor Microenvironment in Driving Breast Cancer Growth and Progression

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Leptin and its receptors are present in the rat olfactory mucosa and modulated by the nutritional status

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Leptin and gastro‐intestinal malignancies

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Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma

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Leptin Induces IL-6 Expression through OBRl Receptor Signaling Pathway in Human Synovial Fibroblasts

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Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation

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Leptin and Adiponectin: Emerging Therapeutic Targets in Breast Cancer

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The pecan nut (Carya illinoinensis) and its oil and polyphenolic fractions differentially modulate lipid metabolism and the antioxidant enzyme activities in rats fed high-fat diets

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Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c‐Fos and ATF1

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The balance between leptin and adiponectin in the control of carcinogenesis – Focus on mammary tumorigenesis

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Leptin increases HER2 protein levels through a STAT3‐mediated up‐regulation of Hsp90 in breast cancer cells

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Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2/STAT3 signaling pathway

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Molecular cloning and characterization of gilthead sea bream (Sparus aurata) growth hormone receptor (GHR). Assessment of alternative splicing

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Obesity portends increased morbidity and earlier recurrence following liver transplantation for hepatocellular carcinoma

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The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis?

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Adipokine regulation of colon cancer: Adiponectin attenuates interleukin‐6‐induced colon carcinoma cell proliferation via STAT‐3

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Leptin Augments Proliferation of Breast Cancer Cells via Transactivation of HER2

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Curcumin Molecular Targets in Obesity and Obesity-Related Cancers

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Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system

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Inhibition of Steroidogenic Response to Adrenocorticotropin by Leptin: Implications for the Adrenal Response to Maternal Separation in Neonatal Rats

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Inter-relations between osteoarthritis and metabolic syndrome: A common link?

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Emerging role of leptin in rheumatoid arthritis

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Leptin protects H9c2 rat cardiomyocytes from H2O2‐induced apoptosis

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Leptin as a neuroprotective agent

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Central leptin treatment modulates brain glucosensing function and peripheral energy metabolism of rainbow trout

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Expression of estrogen receptor alpha increases leptin‐induced STAT3 activity in breast cancer cells

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Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis

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Leptin–leptin receptor are involved in angiogenesis in human hepatocellular carcinoma

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Hypoxia, Leptin, and Vascular Endothelial Growth Factor Stimulate Vascular Endothelial Cell Differentiation of Human Adipose Tissue-Derived Stem Cells

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Adipokines and Obesity Are Associated with Colorectal Polyps in Adult Males: A Cross-Sectional Study

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Systemic Stress Hormone Response in Patients Undergoing Open Heart Surgery With or Without Cardiopulmonary Bypass

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Leptin attenuates hypoxia/reoxygenation‐induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells

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Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy

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Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction

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Leptin repletion restores depressed β‐adrenergic contractility in <i>ob/ob</i> mice independently of cardiac hypertrophy

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The potential role of leptin in the vascular remodeling associated with obesity

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Mechanistic Roles of Leptin in Osteogenic Stimulation in Thoracic Ligament Flavum Cells

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An Overview of Mouse Models of Nonalcoholic Steatohepatitis: From Past to Present

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Leptin intake during the suckling period improves the metabolic response of adipose tissue to a high-fat diet

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Inhibitory effect of visfatin and leptin on human and rat myometrial contractility

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Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes

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In Vivo and in Vitro Evidence That PPARγ Ligands Are Antagonists of Leptin Signaling in Breast Cancer

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Phenotypic effects of an induced mutation of the ObRa isoform of the leptin receptor

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Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible factor-1α in human colorectal cancer

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Appetite regulation and seasonality: implications for obesity

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Leptin Sensitivity in Skeletal Muscle Is Modulated by Diet and Exercise

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Total body aromatization in postmenopausal breast cancer patients is strongly correlated to plasma leptin levels

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Leptin: A potential biomarker for childhood obesity?

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Growth hormone, insulin-like growth factor I, and leptin interaction in human cultured lutein granulosa cells steroidogenesis

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Development of a pharmacologically improved peptide agonist of the leptin receptor

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Transactivation of Epidermal Growth Factor Receptor Is Involved in Leptin-Induced Activation of Janus-Activated Kinase 2 and Extracellular Signal–Regulated Kinase 1/2 in Human Gastric Cancer Cells

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Leptin Modulates Mitochondrial Function, Dynamics and Biogenesis in MCF‐7 Cells

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Intracellular signalling pathways activated by leptin

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Signal transduction mediated by leptin and its receptor

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One Receptor for Multiple Pathways: Focus on Leptin Signaling

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Chapter 3. One Receptor for Multiple Pathways: Focus on Leptin Signaling

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Leptin‐induced signal transduction pathways

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