Cited by 460interferon and immune responsesVirology and Viral DiseasesCellular transport and secretion

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Interferon‐Induced Mx Proteins: Dynamin‐Like GTPases with Antiviral Activity

Haller, Otto, Kochs, Georg·2002·Traffic

DOI 10.1034/j.1600-0854.2002.31003.x

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Abstract

Mx proteins are interferon‐induced GTPases that belong to the dynamin superfamily of large GTPases. Similarities include a high molecular weight, a propensity to self‐assemble, a relatively low affinity for GTP, and a high intrinsic rate of GTP hydrolysis. A unique property of Mx GTPases is their antiviral activity against a wide range of RNA viruses, including bunya‐ and orthomyxoviruses. The human MxA GTPase accumulates in the cytoplasm of interferon‐treated cells, partly associating with the endoplasmic reticulum. In the case of bunyaviruses, MxA interferes with transport of the viral nucleocapsid protein (N) to the Golgi compartment, the site of virus assembly. In the case of Thogoto virus (an orthomyxovirus), MxA prevents the incoming viral nucleocapsids from being transported into the nucleus, the site of viral transcription and replication. In both cases, the GTP‐binding and carboxy‐terminal effector functions of MxA are required for target recognition. In general, Mx GTPases appear to detect viral infection by sensing nucleocapsid‐like structures. As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles.

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Authors: Haller, O., & Kochs, G.
Affiliations: University of Freiburg (DE)
Corresponding author: Haller, Otto
ORCID: Haller, Otto
Kochs, Georg
Venue: Traffic
Publisher: Wiley
Published: 2002-09-16
Volume: 3
Issue: 10
Pages: 710-717
ISSN: 1398-9219 (ISSN-L)
1600-0854
DOI: 10.1034/j.1600-0854.2002.31003.x
OpenAlex: W2090023448
Cited by: 460
References: 53
Citations by year: 2026: 2 · 2025: 10 · 2024: 13 · 2023: 12 · 2022: 9 · 2021: 9 · 2020: 15 · 2019: 8 · 2018: 11 · 2017: 14 · 2016: 8 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 23
FWCI: 2.41
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Traffic (publishedVersion)
PubMed (publishedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: Mx protein, MxA, dynamin superfamily, antiviral activity, Bunyaviridae, orthomyxoviruses, Thogoto virus, Golgi apparatus, endoplasmic reticulum, GTP hydrolysis, viral assembly, RNA viruses, host-virus interaction
MeSH terms: Antiviral Agents, Interferons, Molecular Weight, Subcellular Fractions, GTP-Binding Proteins, GTP Phosphohydrolases, Dynamins, Myxovirus Resistance Proteins

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Interferon‐Induced Mx Proteins: Dynamin‐Like GTPases with Antiviral Activity

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