The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Interferon‐Induced Mx Proteins: Dynamin‐Like GTPases with Antiviral Activity
Abstract
Mx proteins are interferon‐induced GTPases that belong to the dynamin superfamily of large GTPases. Similarities include a high molecular weight, a propensity to self‐assemble, a relatively low affinity for GTP, and a high intrinsic rate of GTP hydrolysis. A unique property of Mx GTPases is their antiviral activity against a wide range of RNA viruses, including bunya‐ and orthomyxoviruses. The human MxA GTPase accumulates in the cytoplasm of interferon‐treated cells, partly associating with the endoplasmic reticulum. In the case of bunyaviruses, MxA interferes with transport of the viral nucleocapsid protein (N) to the Golgi compartment, the site of virus assembly. In the case of Thogoto virus (an orthomyxovirus), MxA prevents the incoming viral nucleocapsids from being transported into the nucleus, the site of viral transcription and replication. In both cases, the GTP‐binding and carboxy‐terminal effector functions of MxA are required for target recognition. In general, Mx GTPases appear to detect viral infection by sensing nucleocapsid‐like structures. As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles.
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“Increased expression of MUC5AC mRNA in bronchial epithelial cells has been reported for mice after RSV infection (97)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [97]
Citations
Cites
Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding
Hinshaw, J. E., & Schmid, S. L. (1995) · Nature · doi:10.1038/374190a0 · Cited by 824
Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation
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Self-citationDynamin and its partners: a progress report
Schmid, S. L., McNiven, M. A., & Camilli, P. V. D. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80066-5 · Cited by 399
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Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis
Sever, S., Muhlberg, A. B., & Schmid, S. L. (1999) · Nature · doi:10.1038/19024 · Cited by 367
Obar, R. A., Collins, C. A., Hammarback, J. A., Shpetner, H. S., & Vallee, R. B. (1990) · Nature · doi:10.1038/347256a0 · Cited by 349
The dynamin family of mechanoenzymes: pinching in new places
McNiven, M. A., Cao, H., Pitts, K. R., & Yoon, Y. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01538-8 · Cited by 343
Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins
Prakash, B., Praefcke, G. J. K., Renault, L., Wittinghofer, A., & Herrmann, C. (2000) · Nature · doi:10.1038/35000617 · Cited by 323
Mx proteins: mediators of innate resistance to RNA viruses
Haller, O., Frese, M., & Kochs, G. (1998) · Scientific and Technical Review (World Organisation for Animal Health) · doi:10.20506/rst.17.1.1084 · Cited by 286
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The dynamin superfamily: universal membrane tubulation and fission molecules?
Praefcke, G. J. K., & McMahon, H. T. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1313 · Cited by 1,370
Crimean-Congo haemorrhagic fever
Ergönül, Ö. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70435-2 · Cited by 1,263
Crimean?Congo hemorrhagic fever
Whitehouse, C. A. (2004) · Antiviral Research · doi:10.1016/j.antiviral.2004.08.001 · Cited by 787
The interferon response circuit: Induction and suppression by pathogenic viruses
Haller, O., Kochs, G., & Weber, F. (2005) · Virology · doi:10.1016/j.virol.2005.09.024 · Cited by 679
Self-citationThe airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Metadata
- Authors
- Haller, O., & Kochs, G.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Haller, Otto
- Venue
- Traffic
- Publisher
- Wiley
- Published
- 2002-09-16
- Volume
- 3
- Issue
- 10
- Pages
- 710-717
- ISSN
- 1398-9219 (ISSN-L)
- 1600-0854
- OpenAlex
- W2090023448
- Cited by
- 460
- References
- 53
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 13 · 2023: 12 · 2022: 9 · 2021: 9 · 2020: 15 · 2019: 8 · 2018: 11 · 2017: 14 · 2016: 8 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 23
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Traffic (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- Mx protein, MxA, dynamin superfamily, antiviral activity, Bunyaviridae, orthomyxoviruses, Thogoto virus, Golgi apparatus, endoplasmic reticulum, GTP hydrolysis, viral assembly, RNA viruses, host-virus interaction
- MeSH terms
- Antiviral Agents, Interferons, Molecular Weight, Subcellular Fractions, GTP-Binding Proteins, GTP Phosphohydrolases, Dynamins, Myxovirus Resistance Proteins
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