The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Can zebrafish be used as a model to study the neurodevelopmental causes of autism?
Abstract
The zebrafish has proven to be an excellent model for analyzing issues of vertebrate development. In this review we ask whether the zebrafish is a viable model for analyzing the neurodevelopmental causes of autism. In developing an answer to this question three topics are considered. First, the general attributes of zebrafish as a model are discussed, including low cost maintenance, rapid life cycle and the multitude of techniques available. These techniques include large‐scale genetic screens, targeted loss and gain of function methods, and embryological assays. Second, we consider the conservation of zebrafish and mammalian brain development, structure and function. Third, we discuss the impressive use of zebrafish as a model for human disease, and suggest several strategies by which zebrafish could be used to dissect the genetic basis for autism. We conclude that the zebrafish system could be used to make important contributions to understanding autistic disorders.
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Cites
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Molecular Mechanisms of Axon Guidance
Dickson, B. J. (2002) · Science · doi:10.1126/science.1072165 · Cited by 1,425
A genetic screen for mutations affecting embryogenesis in zebrafish
Driever, W., Solnica-Krezel, L., Schier, A. F., Neuhauss, S. C. F., Malicki, J., Stemple, D. L., Stainier, D. Y. R., Zwartkruis, F., Abdelilah, S., Rangini, Z., et al. (1996) · Development · doi:10.1242/dev.123.1.37 · Cited by 1,337
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Cited by
The behaviour and ecology of the zebrafish,Danio rerio
Spence, R., Gerlach, G., Lawrence, C., & Smith, C. (2008) · Biological Reviews · doi:10.1111/j.1469-185x.2007.00030.x · Cited by 1,112
Behavioral phenotyping in zebrafish: Comparison of three behavioral quantification methods
Blaser, R., & Gerlai, R. (2006) · Behavior Research Methods · doi:10.3758/bf03192800 · Cited by 294
Barros, T. P., Alderton, W. K., Reynolds, H. M., Roach, A. G., & Berghmans, S. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.249 · Cited by 275
Zebrafish embryos and larvae: A new generation of disease models and drug screens
Ali, S., Champagne, D. L., Spaink, H. P., & Richardson, M. K. (2011) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.20206 · Cited by 257
Function and Regulation of AUTS2, a Gene Implicated in Autism and Human Evolution
Oksenberg, N., Stevison, L., Wall, J. D., & Ahituv, N. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003221 · Cited by 167
Metadata
- Authors
- Tropepe, V., & Sive, H. L.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2003-10
- Volume
- 2
- Issue
- 5
- Pages
- 268-281
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W1525160624
- Cited by
- 257
- References
- 119
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tropepe, V., & Sive, H. L. (2003). Can zebrafish be used as a model to study the neurodevelopmental causes of autism? Genes, Brain and Behavior. https://doi.org/10.1034/j.1601-183x.2003.00038.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
