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Cited by 1,594

The DOI matches its Crossref record.

Altering the Genome by Homologous Recombination

Capecchi, Mario R.·1989·Science
DOI 10.1126/science.2660260
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Abstract

Homologous recombination between DNA sequences residing in the chromosome and newly introduced, cloned DNA sequences (gene targeting) allows the transfer of any modification of the cloned gene into the genome of a living cell. This article discusses the current status of gene targeting with particular emphasis on germ line modification of the mouse genome, and describes the different methods so far employed to identify those rare embryonic stem cells in which the desired targeting event has occurred.

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Crossref · 10.1126/science.2660260

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Citations

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Research works printed but not linked: 32

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  9. FOLGER, K.R., PATTERNS OF INTEGRATION OF DNA MICRO-INJECTED INTO CULTURED MAMMALIAN-CELLS - EVIDENCE FOR HOMOLOGOUS RECOMBINATION BETWEEN INJECTED PLASMID DNA-MOLECULES, MOLECULAR AND CELLULAR BIOLOGY 2: 1372 (1982).
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  19. LIN, F.L., HOMOLOGOUS RECOMBINATION IN MOUSE L-CELLS, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 49: 139 (1984). · DOI
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  22. MULLIS, K.B., SPECIFIC SYNTHESIS OF DNA INVITRO VIA A POLYMERASE-CATALYZED CHAIN-REACTION, METHODS IN ENZYMOLOGY 155: 335 (1987). · DOI
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Cited by

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Metadata

Authors
Capecchi, M. R.
Affiliations
Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City 84112.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1989-06-16
Volume
244
Issue
4910
Pages
1288-1292
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.2660260
Cited by
1,594
References
0
Language
en

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CoChat. (2026). Citation check: Altering the Genome by Homologous Recombination. https://app.cochat.ai/papers/10.1126/science.2660260
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Capecchi, M. R. (1989). Altering the Genome by Homologous Recombination. Science. https://doi.org/10.1126/science.2660260

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