Left frontal hypoactivation in depression.

Jeffrey B. Henriques, Richard J. Davidson·1991·Journal of Abnormal Psychology
DOI 10.1037//0021-843x.100.4.535

Abstract

Baseline resting electroencephalogram activity was recorded with 3 different reference montages from 15 clinically depressed and 13 control subjects. Power in all frequency bands was extracted by fast Fourier transformation. There was a significant Group X Hemisphere interaction in the mid-frontal region, for the alpha band power only. Depressed subjects had less left-sided activation (i.e., more alpha activity) than did normal control subjects. This pattern of diminished left-sided frontal activation is interpreted as indicating a deficit in approach mechanisms in depressed subjects.

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CoChat. (2026). Citation check: Left frontal hypoactivation in depression. https://app.cochat.ai/papers/10.1037//0021-843x.100.4.535
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Henriques, J. B., & Davidson, R. J. (1991). Left frontal hypoactivation in depression. Journal of Abnormal Psychology. https://doi.org/10.1037//0021-843x.100.4.535

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