Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: A diagnostic efficiency analysis.

Abstract

Numerous studies suggest that the relatives of schizophrenic patients exhibit neuropsychological impairments that are milder yet similar to those seen among schizophrenic patients. The authors assessed 35 nonpsychotic relatives of schizophrenic patients and 72 normal controls using a clinical and experimental neuropsychological test battery. Three neuropsychological functions met criteria for risk indicators of the schizophrenia genotype: abstraction, verbal memory, and auditory attention. These findings could not be attributed to parental socioeconomic status, education, general visual-spatial ability, or psychopathology. Furthermore, exploratory analyses were performed to determine whether the diagnostic efficiency of the indicators could be adjusted to meet the needs of genetic linkage analyses. These analyses suggest that psychometric considerations may help to create measures for genetic linkage studies.

Cites (111)

1. Diagnostic and Statistical Manual of Mental Disorders
   Williams, Janet B. W., First, Michael · 2013 · Encyclopedia of Social Work
2. Statistical Theories of Mental Test Scores
   Rozeboom, William W., Lord, Frederic M., Novick, Melvin R., Birnbaum, Allan · 1969 · American Educational Research Journal
3. Diagnostic and Statistical Manual of Mental Disorders, 3rd ed
   COOPER, ARNOLD M., MICHELS, ROBERT · 1981 · American Journal of Psychiatry
4. Four Factor Index of Social Status
   Roi Paschou · 1975
5. A Diagnostic Interview: The Schedule for Affective Disorders and Schizophrenia
   Endicott, Jean · 1978 · Archives of General Psychiatry
6. Manual for the Wechsler Adult Intelligence Scale.
   David Wechsler · 1955 · Psychological Corp. eBooks
7. Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
   Weinberger, Daniel R. · 1987 · Archives of General Psychiatry
8. The Halstead-Reitan neuropsychological test battery: Theory and clinical interpretation
   Ralph M. Reitan, D.E. Wolfson · 1993 · Medical Entomology and Zoology
9. Large-scale neurocognitive networks and distributed processing for attention, language, and memory
   Mesulam, M‐Marsel · 1990 · Annals of Neurology
10. A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem.
    Grant, David A., Berg, Esta · 1948 · Journal of Experimental Psychology

Show all 111 references

Cited by (20)

1. Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
   Egan, Michael F., Goldberg, Terry E., Kolachana, Bhaskar S., Callicott, Joseph H., Mazzanti, Chiara M., Straub, Richard E., Goldman, David, Weinberger, Daniel R. · 2001 · Proceedings of the National Academy of Sciences
2. A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder
   van Os, J., Linscott, R. J., Myin-Germeys, I., Delespaul, P., Krabbendam, L. · 2009 · Psychological Medicine
3. Untitled work
   2009
4. Neurocognition in first-episode schizophrenia: a meta-analytic review.
   Mesholam-Gately, Raquelle I., Giuliano, Anthony J., Goff, Kirsten P., Faraone, Stephen V., Seidman, Larry J. · 2009 · Neuropsychology
5. The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardization
   Kern, Robert S., Nuechterlein, Keith H., Green, Michael F., Baade, Lyle E., Fenton, Wayne S., Gold, James M., Keefe, Richard S.E., Mesholam-Gately, Raquelle, Mintz, Jim, Seidman, Larry J. et al. · 2008 · American Journal of Psychiatry

See all 276