Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia.

Abstract

In this article, we review research designed to examine the influence of neuroleptic and anticholinergic drugs on cognitive processes in schizophrenia. The review is motivated by the recognition that pharmacotherapy is an important factor in psychological research on schizophrenia, given that the great majority of patients studied in investigations of cognition receive both of these drugs. We find that neuroleptic treatment is associated with limited normalization on many psychological measures, whereas anticholinergics appear to disrupt some aspects of memory. Subject selection criteria, research designs, and drug measurement methods important in the evaluation of possible drug effects in psychological studies are discussed.

Cites (67)

1. The Brief Psychiatric Rating Scale.
   Overall, John E., Gorham, Donald R. · 1962 · Psychological Reports
2. Diagnostic and Statistical Manual of Mental Disorders, 3rd ed
   COOPER, ARNOLD M., MICHELS, ROBERT · 1981 · American Journal of Psychiatry
3. Clozapine for the Treatment-Resistant Schizophrenic: A Double-blind Comparison With Chlorpromazine
   Kane, John · 1988 · Archives of General Psychiatry
4. A continuous performance test of brain damage
   Rosvold, H. Enger, Mirsky, Allan F., Sarason, Irwin, Bransome, Edwin D., Beck, Lloyd H. · 1956 · Journal of Consulting Psychology
5. Psychopharmacology: The Third Generation of Progress.
   1988 · Annals of Internal Medicine
6. The Measurement of Adult Intelligence.
   1940 · Archives of Neurology And Psychiatry
7. Research Diagnoses for Tardive Dyskinesia
   Kane, John M. · 1982 · Archives of General Psychiatry
8. Psychopharmacology. A Review of Progress, 1957-1967
   Burger, Alfred · 1969 · Journal of Medicinal Chemistry
9. Abstract and concrete behavior an experimental study with special tests.
   Goldstein, Kurt, Scheerer, Martin · 1941 · Psychological Monographs
10. Drug and Sociotherapy in the Aftercare of Schizophrenic Patients: II. Two-Year Relapse Rates
    Hogarty, Gerard E. · 1974 · Archives of General Psychiatry

Show all 67 references

Cited by (21)

1. Neurocognitive deficit in schizophrenia: A quantitative review of the evidence.
   Heinrichs, R. Walter, Zakzanis, Konstantine K. · 1998 · Neuropsychology
2. Neuropsychological Function in Schizophrenia: Selective Impairment in Memory and Learning
   Saykin, Andrew J. · 1991 · Archives of General Psychiatry
3. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia
   Saykin, Andrew J. · 1994 · Archives of General Psychiatry
4. The Effects of Clozapine, Risperidone, and Olanzapine on Cognitive Function in Schizophrenia
   Meltzer, H. Y., McGurk, S. R. · 1999 · Schizophrenia Bulletin
5. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs
   Miyamoto, S, Duncan, G E, Marx, C E, Lieberman, J A · 2005 · Molecular Psychiatry

See all 381