A randomized clinical trial of a manual-guided risk reduction intervention for HIV-positive injection drug users.

Margolin, Arthur, Avants, S. Kelly, Warburton, Lara A., Hawkins, Keith A., Shi, Julia·2003·Health Psychology
DOI 10.1037//0278-6133.22.2.223

Abstract

This study randomized 90 HIV-seropositive, methadone-maintained injection drug users (IDUs) to an HIV Harm Reduction Program (HHRP+) or to an active control that included harm reduction components recommended by the National AIDS Demonstration Research Project. The treatment phase lasted 6 months, with follow-ups at 6 and 9 months after treatment entry. Patients in both treatments showed reductions in risk behaviors. However, patients assigned to HHRP+ were less likely to use illicit opiates and were more likely to adhere to antiretroviral medications during treatment; at follow-up, they had lower addiction severity scores and were less likely to have engaged in high risk behavior. Findings suggest that enhancing methadone maintenance with an intervention targeting HIV-seropositive IDUs increases both harm reduction and health promotion behaviors.

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Cited by (11)

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  2. Treatment of medical, psychiatric, and substance-use comorbidities in people infected with HIV who use drugs
    Altice, Frederick L, Kamarulzaman, Adeeba, Soriano, Vincent V, Schechter, Mauro, Friedland, Gerald H · 2010 · The Lancet
  3. Medication adherence and persistence: A comprehensive review
    Krueger, Kem P., Berger, Bruce A., Felkey, Bill · 2005 · Advances in Therapy
  4. Patient support and education for promoting adherence to highly active antiretroviral therapy for HIV/AIDS
    Rueda, Sergio, Park-Wyllie, Laura Y., Bayoumi, Ahmed, Tynan, Anne-Marie, Antoniou, Tony, Rourke, Sean, Glazier, Richard · 2006 · Cochrane Database of Systematic Reviews
  5. Oral substitution treatment of injecting opioid users for prevention of HIV infection
    Gowing, Linda, Farrell, Michael F, Bornemann, Reinhard, Sullivan, Lynn E, Ali, Robert · 2011 · Cochrane Database of Systematic Reviews

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Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: A randomized clinical trial of a manual-guided risk reduction intervention for HIV-positive injection drug users. https://app.cochat.ai/papers/10.1037//0278-6133.22.2.223
The paper
Margolin, A., Avants, S. K., Warburton, L. A., Hawkins, K. A., & Shi, J. (2003). A randomized clinical trial of a manual-guided risk reduction intervention for HIV-positive injection drug users. Health Psychology. https://doi.org/10.1037//0278-6133.22.2.223

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.