Hippocampal system dysfunction and odor discrimination learning in rats: Impairment of facilitation depending on representational demands.

Eichenbaum, Howard, Fagan, A., Mathews, P., Cohen, N. J.·1988·Behavioral Neuroscience
DOI 10.1037//0735-7044.102.3.331

Abstract

The performance of normal rats and that of rats with hippocampal system damage were compared on acquisition of different versions of the same two-odor discrimination task that placed different encoding and representational demands on memory. Rats with fornix lesions were impaired when explicit comparisons among multiple odor cues and differential response choices were encouraged. However, when odor-cue comparison was hindered and explicit cues for response choice were eliminated, rats with fornix lesions out performed normal animals. The results support an hypothesis that the hippocampal system is critical to a memory representation based on encoding relations among multiple percepts, and other brain systems support performance adaptations based on encodings of stimuli individually.

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Cited by (22)

  1. Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
    Squire, Larry R. · 1992 · Psychological Review
  2. Characteristics of dissociable human learning systems
    Shanks, David R., St. John, Mark F. · 1994 · Behavioral and Brain Sciences
  3. Interactive memory systems in the human brain
    Poldrack, R. A., Clark, J., Paré-Blagoev, E. J., Shohamy, D., Creso Moyano, J., Myers, C., Gluck, M. A. · 2001 · Nature
  4. The Structure and Organization of Memory
    Squire, L. R., Knowlton, B., Musen, G. · 1993 · Annual Review of Psychology
  5. Multiple Parallel Memory Systems in the Brain of the Rat
    White, Norman M., McDonald, Robert J. · 2002 · Neurobiology of Learning and Memory

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CoChat. (2026). Citation check: Hippocampal system dysfunction and odor discrimination learning in rats: Impairment of facilitation depending on representational demands. https://app.cochat.ai/papers/10.1037//0735-7044.102.3.331
The paper
Eichenbaum, H., Fagan, A., Mathews, P., & Cohen, N. J. (1988). Hippocampal system dysfunction and odor discrimination learning in rats: Impairment of facilitation depending on representational demands. Behavioral Neuroscience. https://doi.org/10.1037//0735-7044.102.3.331

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