The DOI matches its Crossref record.
Tobacco withdrawal in self-quitters
Abstract
Self-reported and observer-rated signs and symptoms of nicotine withdrawal were assessed precessation and 2, 7, 14, 30, 90, and 180 days postcessation in smokers who quit on their own for 30 days. Anxiety, difficulty concentrating, hunger, irritability, restlessness, and weight gain increased, and heart rate decreased, postcessation (p less than .001). Except for hunger and weight gain, these symptoms returned to precessation levels by 30 days postcessation. Craving, depression, and alcohol or caffeine intake did not reliably increase. Postcessation depression, but not withdrawal symptoms, craving, or weight gain, predicted relapse. These results are consistent with prior studies.
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“These symptoms include difficulty concentrating, increased craving, depressed mood, and increased anxiety (Hughes, 1992(Hughes, , 2007)).”
From Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors (2014) · cites this paper as Hughes, 1992
In the citing paper
“In humans, although most reports of anxiety occur during the first 24 hours, a return to baseline can take up to 4 weeks (Hughes, 1992).”
From Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors (2014) · cites this paper as Hughes, 1992
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Chronic stress, drug use, and vulnerability to addiction
Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904
A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation
Jorenby, D. E., Leischow, S. J., Nides, M. A., Rennard, S. I., Johnston, J. A., Hughes, A. R., Smith, S. S., Muramoto, M. L., Daughton, D. M., Doan, K., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903043400903 · Cited by 1,585
Smoking, stress, and negative affect: Correlation, causation, and context across stages of smoking.
Kassel, J. D., Stroud, L. R., & Paronis, C. A. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.2.270 · Cited by 1,113
Guidelines on nicotine dose selection for in vivo research
Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824
Effects of abstinence from tobacco: Valid symptoms and time course
Hughes, J. (2007) · Nicotine & Tobacco Research · doi:10.1080/14622200701188919 · Cited by 801
Self-citation
Metadata
- Authors
- Hughes, J. R.
- Affiliations
- University of Vermont (US)
- Corresponding author
- Hughes, John R.
- ORCID
- Hughes, John R.
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 1992
- Volume
- 60
- Issue
- 5
- Pages
- 689-697
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- OpenAlex
- W2047127806
- Cited by
- 412
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 2 · 2021: 11 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 11 · 2015: 10 · 2014: 15 · 2013: 22 · 2012: 10
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl039220-03)
- National Heart, Lung, and Blood Institute (HL39220)
- National Institute on Drug Abuse (DA00109)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- nicotine withdrawal, smoking cessation, withdrawal symptoms, anxiety, depression, craving, recurrence prediction, weight gain, heart rate, self-reported symptoms, observer ratings
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Motivation, Nicotine, Prospective Studies, Recurrence, Smoking, Substance Withdrawal Syndrome, Smoking Cessation
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