Cited by 146Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesNicotinic Acetylcholine Receptors Study

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Randomized clinical trial of the efficacy of bupropion combined with nicotine patch in the treatment of adolescent smokers

Killen, Joel D., Robinson, Thomas N., Ammerman, Seth, Hayward, Chris, Rogers, Jayna, Stone, Christi, Samuels, Deanne, Levin, Sara K., Green, Sarah, Schatzberg, Alan F.·2004·Journal of Consulting and Clinical Psychology

DOI 10.1037/0022-006x.72.4.729

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Abstract

Adolescent smokers (N = 211) were randomized to 1 of 2 groups: (a) nicotine patch plus bupropion SR (sustained release; 150 mg per day) or (b) nicotine patch plus placebo. Group skills training sessions were conducted each week by research staff. Abstinence rates at Weeks 10 and 26 were as follows: (a) patch plus bupropion, 23% and 8%, (b) patch plus placebo, 28% and 7%. Despite the lack of a treatment effect, a large majority of adolescents in both treatment groups reduced their consumption to a few cigarettes per day or less and maintained this reduction over time. Similarly, an examination of survival curves revealed that by the end of treatment many had managed to avoid a return to daily smoking. These findings are encouraging and suggest new avenues for research. For example, treatments of the kind examined in this report, augmented by extended maintenance therapies, may yield higher long-term success rates.

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Authors: Killen, J. D., Robinson, T. N., Ammerman, S., Hayward, C., Rogers, J., Stone, C., Samuels, D., Levin, S. K., Green, S., & Schatzberg, A. F.
Affiliations: Stanford Medicine (US)
ORCID: Robinson, Thomas N.
Rogers, Jayna
Levin, Sara K.
Green, Sarah
Schatzberg, Alan F.
Venue: Journal of Consulting and Clinical Psychology
Publisher: American Psychological Association (APA)
Published: 2004
Volume: 72
Issue: 4
Pages: 729-735
ISSN: 0022-006X (ISSN-L)
1939-2117
DOI: 10.1037/0022-006x.72.4.729
OpenAlex: W2170062274
Cited by: 146
References: 18
Citations by year: 2026: 4 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 11 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 10 · 2014: 7 · 2013: 8 · 2012: 8
FWCI: 7.40
Type: journal article
Language: en
Open access: closed
Locations: Journal of Consulting and Clinical Psychology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ca080268-04)
National Cancer Institute (CA80268)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: adolescent smoking, bupropion, nicotine patch, smoking cessation, nicotine replacement therapy, bupropion sustained release, abstinence rates, smoking reduction, skills training, maintenance therapy
MeSH terms: Smoking Prevention, Administration, Cutaneous, Adolescent, Drug Therapy, Combination, Female, Humans, Male, Nicotine, Tobacco Use Disorder, Smoking Cessation, Bupropion, Dopamine Uptake Inhibitors

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Randomized clinical trial of the efficacy of bupropion combined with nicotine patch in the treatment of adolescent smokers

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