Cited by 155Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeuroscience and Neuropharmacology Research

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Biological consequences of drug administration: Implications for acute and chronic tolerance

Ramsay, Douglas S., Woods, Stephen C.·1997·Psychological Review

DOI 10.1037/0033-295x.104.1.170

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Abstract

The authors presented a model that extrapolates the biological consequences of drug administration to account for acute and chronic tolerance. Drug-induced changes of regulated parameters provide detectable perturbations to which the brain responds. With experience, these centrally mediated responses are learned and can be activated in the absence of the drug-induced perturbation. Although neural responses following drug administration are often obscured, the model shows how these responses may be identified and provides a reinterpretation of drug conditioning paradigms. The authors made comparisons between the present empirical model of drug administration and existing theories of drug tolerance. The authors also presented a unified framework for understanding the consequences of repeated drug use and made specific predictions as to the relationships among acute and chronic tolerance, drug sensitization, and individual differences in vulnerability to drug addiction.

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Self-citation

Authors: Ramsay, D. S., & Woods, S. C.
Affiliations: University of Washington (US)
ORCID: Ramsay, Douglas S.
Woods, Stephen C.
Venue: Psychological Review
Publisher: American Psychological Association (APA)
Published: 1997-01
Volume: 104
Issue: 1
Pages: 170-193
ISSN: 0033-295X (ISSN-L)
1939-1471
DOI: 10.1037/0033-295x.104.1.170
OpenAlex: W1980751644
Cited by: 155
References: 149
Citations by year: 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 2
FWCI: 4.46
Type: journal article
Language: en
Open access: closed
Locations: Psychological Review (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (R29DA007391, DA 07391)
National Institute of Dental and Craniofacial Research (DE-00379, K16DE000161, DE 00161)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: drug tolerance, acute tolerance, drug sensitization, drug conditioning, drug addiction vulnerability, individual differences
MeSH terms: Animals, Brain, Conditioning, Classical, Drug Tolerance, Humans, Substance-Related Disorders

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Biological consequences of drug administration: Implications for acute and chronic tolerance

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