Correlates of functional disability in patients with postural tachycardia syndrome: preliminary cross-sectional findings
Abstract
The study investigated correlates of functional disability in 94 patients (89.4% women, 10.6% men; mean age=34.2 years) with postural tachycardia syndrome (POTS), a clinical syndrome of orthostatic intolerance characterized by significant functional limitations. Path analysis supported a model in which, controlling for demographic and disease variables, catastrophic cognitions were directly related to the latent variable functional disability, whereas somatic vigilance, anxiety sensitivity, and neuroticism were indirectly associated with functional disability through their relationship with catastrophic cognitions. Results suggest that modifiable psychological factors play a role in the functional limitations experienced by patients with POTS. Longitudinal research is necessary to confirm these relationships.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Higher pain disability scores had a significant medium correlation with higher symptom burden.
“higher pain disability scores had a significant medium correlation with higher symptom burden (Benrud-Larson et al., 2003”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Benrud-Larson et al., 2003
A modified version of the catastrophizing subscale of the coping strategies questionnaire had a small significant correlation with greater symptom burden.
“whereas one high quality study found that a modified version of the catastrophizing subscale of the coping strategies questionnaire (assessing catastrophic thinking in response to autonomic symptoms) had a small significant correlation with greater symptom burden (Benrud-Larson et al., 2003”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Benrud-Larson et al., 2003
Functioning and health-related quality of life demonstrated significant medium-large correlations with self-reported symptom burden in four medium-high quality studies, with more severe symptoms associated with increased impairment.
“All of these demonstrated significant medium-large correlations with self-reported symptom burden, where more severe symptoms were associated with increased impairment”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Benrud-Larson et al., 2003
Anxiety sensitivity was not significantly correlated with autonomic symptoms in two studies, despite elevated levels of anxiety sensitivity in POTS patients in one study.
“was not significantly correlated with autonomic symptoms in two studies (Benrud-Larson et al., 2003”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Benrud-Larson et al., 2003
Two studies found medium correlations between higher symptom burden scores and higher depression scores, and one large study also found this association.
“Two found medium correlations (Benrud-Larson et al., 2003”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Benrud-Larson et al., 2003
Two studies found small-medium correlations between higher catastrophizing scores and higher symptom burden.
“Two medium-high quality studies explored catastrophizing (viewing or presenting a situation or future situation as considerably worse than it is) in relation to symptom burden and found small-medium correlations (Benrud-Larson et al., 2003”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Benrud-Larson et al., 2003
The correlation between higher anxiety and greater symptom burden was reported significant in one larger study (n = 94) but not the smaller one (n = 58).
“The correlation was reported significant in one larger study (n = 94) (Benrud-Larson et al., 2003”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Benrud-Larson et al., 2003
A small association was found in two studies between higher anxiety and greater autonomic/orthostatic symptom burden.
“A small association was found in two studies between higher anxiety and greater autonomic/orthostatic symptom burden (Benrud-Larson et al., 2003”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Benrud-Larson et al., 2003
Neuroticism showed a small non-significant positive correlation with symptom burden in one high quality study.
“Neuroticism (experiencing the world as distressing, unsafe or threatening) showed a small non-significant positive correlation with symptom burden in one high quality study (Benrud-Larson et al., 2003”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Benrud-Larson et al., 2003
Chronic illness in POTS predisposes to impaired health-related quality of life and functional disability that limit activities of daily living.
“The presence of chronic illness in POTS predisposes to impaired health-related quality of life as well as functional disability that limit activities of daily living”
From Postural tachycardia syndrome – Diagnosis, physiology, and prognosis (2018) · cites this paper as Benrud-Larson et al., 2003
A large proportion of POTS patients experience reduced health-related quality of life and functional disability.
“Many POTS patients have impaired health-related quality of life and functional disability (Benrud-Larson et al., 2003;Benrud-Larson et al., 2002), which can contribute to physical deconditioning.”
From Postural tachycardia syndrome – Diagnosis, physiology, and prognosis (2018) · cites this paper as Benrud-Larson et al., 2003
The citation lists haven’t been fetched yet
References 31 · Cited by 74
- Authors
- Benrud-Larson, L. M., Sandroni, P., Haythornthwaite, J. A., Rummans, T. A., & Low, P. A.
- Affiliations
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Venue
- Health Psychology
- Published
- 2003
- Volume
- 22
- Issue
- 6
- Pages
- 643-648
- ISSN
- 0278-6133 (ISSN-L)
- 1930-7810
- OpenAlex
- W2025753119
- Cited by
- 74
- References
- 31
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 5
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Health Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS3 2352, NS 02225, K24NS002225)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 07447)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- postural orthostatic tachycardia syndrome, functional disability, catastrophic cognitions, anxiety sensitivity, neuroticism, orthostatic intolerance, psychological factors, path analysis
- MeSH terms
- Activities of Daily Living, Adult, Anxiety Disorders, Cross-Sectional Studies, Depression, Disability Evaluation, Female, Humans, Hypotension, Orthostatic, Male, Minnesota, Models, Psychological, Neuropsychological Tests, Posture, Somatoform Disorders, Tachycardia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
