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Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study.
Abstract
The effect of hyperglycemia on hormone levels, metabolite levels, and memory performance was examined in 22 subjects with very mild and mild probable dementia of the Alzheimer type (DAT) and in 12 normal elderly adults. Subjects were tested in 3 plasma glucose conditions (fasting baseline, 175 mg/dl, and 225 mg/dl) at initial and 18-month follow-up sessions. Initially, adults with very mild DAT showed memory facilitation and elevations in plasma insulin in the 225-mg/dl glucose condition relative to baseline. At follow-up, very mild DAT patients whose dementia had progressed showed significant decreases in insulin and hyperglycemic memory facilitation. Changes in basal insulin and cortisol levels over time were correlated with memory changes for DAT subjects. These results suggest that glucoregulatory abnormalities may contribute to the pathophysiology of DAT.
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“Elevated glucose levelsas indexed by fasting glucose or more integrated assessments of glucose metabolism such as glycosylated hemoglobin (HgA1c)-have also been related to heart disease risk; 15 to higher mortality; 16 and to poorer cognitive [17][18][19][20] and physical function.8”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [17]
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Metadata
- Authors
- Craft, S., Dagogo-Jack, S. E., Wiethop, B. V., Murphy, C., Nevins, R. T., Fleischman, S., Rice, V., Newcomer, J. W., & Cryer, P. E.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Behavioral Neuroscience
- Published
- 1993
- Volume
- 107
- Issue
- 6
- Pages
- 926-940
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2047478253
- Cited by
- 191
- References
- 0
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 4
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 05681, P50AG005681)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK27085)
- National Center for Research Resources (5M01 RR-00036, M01RR000036)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- hyperglycemia, Alzheimer's disease, memory, insulin, cortisol, glucoregulation, plasma glucose, dementia progression, hormone levels, older adults
- MeSH terms
- Aged, Alzheimer Disease, Blood Glucose, Brain, Brain Mapping, Discrimination Learning, Female, Glucagon, Glycated Hemoglobin, Hippocampus, Hormones, Humans, Insulin, Longitudinal Studies, Male, Middle Aged, Paired-Associate Learning, Pattern Recognition, Visual, Mental Recall, Retention, Psychology, Speech Perception
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