The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment.
Abstract
Chronic restraint stress causes significant dendritic atrophy of CA3 pyramidal neurons that reverts to baseline within a week. Therefore, the authors assessed the functional consequences of this atrophy quickly (within hours) using the Y maze. Experiments 1-3 demonstrated that rats relied on extrinsic, spatial cues located outside of the Y maze to determine arm location and that rats with hippocampal damage (through kainic acid, colchicine, or trimethyltin) had spatial memory impairments. After the Y maze was validated as a hippocampally relevant spatial task, Experiment 4 showed that chronic restraint stress impaired spatial memory performance on the Y maze when rats were tested the day after the last stress session and that tianeptine prevented the stress-induced spatial memory impairment. These data are consistent with the previously demonstrated ability of tianeptine to prevent chronic stress-induced atrophy of the CA3 dendrites.
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Cites
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Place navigation impaired in rats with hippocampal lesions
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Self-citationStress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
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Self-citationProlonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging
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Self-citationOn the role of the hippocampus in learning and memory in the rat.
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Self-citationHippocampal representation in place learning
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Cited by
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Self-citationBrain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Self-citationMcEwen, B. S. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02950-4 · Cited by 1,827
Self-citationStress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795
Metadata
- Authors
- Conrad, C. D., Galea, L. A. M., Kuroda, Y., & McEwen, B. S.
- Venue
- Behavioral Neuroscience
- Published
- 1996-12
- Volume
- 110
- Issue
- 6
- Pages
- 1321-1334
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W1979987497
- Cited by
- 784
- References
- 83
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Conrad, C. D., Galea, L. A. M., Kuroda, Y., & McEwen, B. S. (1996). Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment. Behavioral Neuroscience. https://doi.org/10.1037/0735-7044.110.6.1321
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
