On the role of the hippocampus in learning and memory in the rat.

Jarrard, Leonard E.

doi:10.1016/0163-1047(93)90664-4

Cited by 1,125Memory and Neural MechanismsMemory Processes and InfluencesNeurogenesis and neuroplasticity mechanisms

On the role of the hippocampus in learning and memory in the rat.

Jarrard, Leonard E.·1993·Behavioral and Neural Biology

DOI 10.1016/0163-1047(93)90664-4

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Abstract

An overview of lesion experiments concerned with the involvement of the hippocampus in learning and memory in the rat is presented. Multiple injections of small amounts of ibotenic acid were used to selectively remove the hippocampus (dentate gyrus, hilar cells, CA1-CA3 pyramidal cells). Similar selective, axon-sparing ibotenate lesions of hippocampus were used in a series of learning and memory experiments employing tasks that are thought to be important in hippocampal function. The performance of rats with the hippocampus removed was compared with that of control animals in the acquisition and retention of spatial versus nonspatial information, forgetting of spatial and nonspatial information, contextual learning, recognition memory and concurrent discrimination learning, and complex representational learning (conditional discrimination and negative patterning learning). The general finding that rats without a hippocampus were impaired on those tasks that required the utilization of spatial and contextual information stands in contrast with the spared performance that was found in learning about and handling (even complex) nonspatial information. Rather than support for views that emphasize a role for the hippocampus in specific memory processes (working memory, declarative memory, temporary memory buffer, configural learning), the present results are more compatible with the idea that the hippocampus plays an especially important role in processing and remembering spatial and contextual information. The limited data that are available using more selective lesions of related hippocampal formation structures (entorhinal cortex, subiculum) suggest that these structures also make important contributions to learning and memory, and that some of these contributions may be different from those made by the hippocampus.

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The hippocampus plays an important role in both learning and memory.
“The hippocampus plays an important role in both learning and memory (Jarrard, 1993) and affective processing (Phillips et al., 2003).”
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Authors: Jarrard, L. E.
Affiliations: Washington and Lee University (US)
Corresponding author: Jarrard, Leonard E.
Venue: Behavioral and Neural Biology
Publisher: Elsevier BV
Published: 1993-07
Volume: 60
Issue: 1
Pages: 9-26
ISSN: 0163-1047 (ISSN-L)
DOI: 10.1016/0163-1047(93)90664-4
OpenAlex: W2050490622
Cited by: 1,125
References: 84
Citations by year: 2026: 9 · 2025: 26 · 2024: 28 · 2023: 26 · 2022: 29 · 2021: 34 · 2020: 29 · 2019: 12 · 2018: 25 · 2017: 29 · 2016: 24 · 2015: 29 · 2014: 37 · 2013: 30 · 2012: 21
FWCI: 37.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioral and Neural Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: hippocampus, learning and memory, ibotenate lesions, spatial learning, contextual learning, recognition memory, forgetting, conditional discrimination, negative patterning, entorhinal cortex, subiculum, dentate gyrus
MeSH terms: Animals, Behavior, Animal, Discrimination Learning, Hippocampus, Memory, Neural Pathways, Space Perception, Rats

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On the role of the hippocampus in learning and memory in the rat.

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